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Its association with SCN1B is required for stabilizing the perinexus in the ICD and for localization of GJA1 and SCN5A to the ICD (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40691517"}],"value":"Inhibited by CGP-37157, the mitochondrial sodium/calcium exchange inhibitor"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4VAE3"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26403541"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40200126"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"40691517"}],"value":"Monomer (By similarity). Homodimer (PubMed:26403541, PubMed:40691517). Interacts with SLC8B1/NCLX; required for SLC8B1/NCLX antiporter activity (PubMed:40200126). Interacts with GJA1 (By similarity). Interacts weakly with DSP (By similarity). 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