{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6PGW3","uniProtkbId":"ARMD3_DANRE","entryAudit":{"firstPublicDate":"2007-04-17","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-04","entryVersion":100,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Danio rerio","commonName":"Zebrafish","synonyms":["Brachydanio rerio"],"taxonId":7955,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Ostariophysi","Cypriniformes","Danionidae","Danioninae","Danio"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5T2E6"}],"value":"Armadillo-like helical domain-containing protein 3"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5T2E6"}],"value":"armh3"},"orfNames":[{"value":"zgc:63733"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5T2E6"}],"value":"May be involved in Golgi maintenance and protein secretion"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5T2E6"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5T2E6"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ARMH3 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH56810.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":689,"modifier":"EXACT"}},"description":"Armadillo-like helical domain-containing protein 3","featureId":"PRO_0000284517"},{"type":"Transmembrane","location":{"start":{"value":520,"modifier":"EXACT"},"end":{"value":538,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-2NS8UMIS8F0NT","citationType":"submission","authoringGroup":["NIH - Zebrafish Gene Collection (ZGC) project"],"publicationDate":"AUG-2003","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"AB","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC056810","properties":[{"key":"ProteinId","value":"AAH56810.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_956913.2","properties":[{"key":"NucleotideSequenceId","value":"NM_200619.2"}]},{"database":"AlphaFoldDB","id":"Q6PGW3","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6PGW3","properties":[{"key":"Number of interactors","value":"1247"}]},{"database":"STRING","id":"7955.ENSDARP00000140852","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q6PGW3","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"PaxDb","id":"7955-ENSDARP00000140852","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6PGW3","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSDART00000162211","properties":[{"key":"ProteinId","value":"ENSDARP00000140852"},{"key":"GeneId","value":"ENSDARG00000104285"}]},{"database":"GeneID","id":"393591","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dre:393591","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"ZFIN:ZDB-GENE-040426-1249","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79591","properties":[{"key":"Description","value":"-"}]},{"database":"ZFIN","id":"ZDB-GENE-040426-1249","properties":[{"key":"GeneName","value":"armh3"}]},{"database":"eggNOG","id":"KOG4654","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002554","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_029861_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6PGW3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YEATHLN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2012278at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q6PGW3","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q6PGW3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000437","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"Bgee","id":"ENSDARG00000104285","properties":[{"key":"ExpressionPatterns","value":"Expressed in blastula and 21 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1903358","properties":[{"key":"GoTerm","value":"P:regulation of Golgi organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR039868","properties":[{"key":"EntryName","value":"ARMD3-like"}]},{"database":"InterPro","id":"IPR013636","properties":[{"key":"EntryName","value":"ARMH3_C"}]},{"database":"PANTHER","id":"PTHR13608","properties":[{"key":"EntryName","value":"ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13608:SF3","properties":[{"key":"EntryName","value":"ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08427","properties":[{"key":"EntryName","value":"ARMH3_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01158","properties":[{"key":"EntryName","value":"DUF1741"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAQTEKKAGLLRRTSSSKKPLKEKVVLMYDEIFMKEDPTKNSPRFWDELFLMKVNLEYLEGKLESLDGDEFMKIKDNINSLFHHCVQALAEEHQIKVVNALQTLCALFRGVHQKNKSATGFDIINMLIGFDKAELRMKELMESLDSLLCGDGSESLKSLCLKLLLCLVTVTDNISQNTILEYVMINSIFEAILQILSDVSSRSQHGYDSVVLLALLVNYRKYESVNPYIVKLSIVDDEPTLDGLGMVIHHALTEYNRQYKEKEEENQGGFFSTLSSMVGSMFIADADEKLSVQTNEAILLALYEAVHLNRNFITVLAQSHPEIDMAATPATPVPASPTTPLGTTPPSLDLMNNPELPLDPNLQTSNLLITFLKYSSIVMQDTKDEHRLNSARLCLIILTCIAEDQYADAFLHDDNMNFRVNLHRMPMRHRKKAADKNIPCRPLVCAVLDLMVEFVVTHMMKEFPMDLYVRCVQIIHKLICYQKKCRVRLHYTWRELWSALINLLKFLLSNETGLLAKHNIFQLALQVVNLFNMFITYGDTFLPTPSSYDELYYEIIRMHQVFDNLYCMVLRVSTNAGQWKEPASKVTHALVNVRAIINHFNPKIESYAAVNHISQLSEDQVLEVVRSNYDTLTLKLQDGLDQFERYSEQPREAGFFKELVRSISLNVRKNVSLTTMSQDVLLKEFSSIS","length":689,"molWeight":78779,"crc64":"3B84EE1E3984C568","md5":"5BE6B7804CBBA1604BE06CA60D96F3CC"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":1},"uniParcId":"UPI000181EF49"}}