{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6PD62","secondaryAccessions":["D3DQV8","Q15015"],"uniProtkbId":"CTR9_HUMAN","entryAudit":{"firstPublicDate":"2006-04-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":188,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"RNA polymerase-associated protein CTR9 homolog"}},"alternativeNames":[{"fullName":{"value":"SH2 domain-binding protein 1"}}]},"genes":[{"geneName":{"value":"CTR9"},"synonyms":[{"value":"KIAA0155"},{"value":"SH2BP1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16024656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16307923"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19345177"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19952111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20178742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20541477"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21329879"}],"value":"Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16024656"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19952111"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20178742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20541477"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26030138"}],"value":"Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8 (PubMed:16024656, PubMed:19952111, PubMed:20178742). The PAF1 complex interacts with PHF5A (By similarity). Interacts with KMT2A/MLL1 (PubMed:20541477). Interacts with STAT3 (By similarity). Interacts with SETD5 (By similarity). Interacts with ERCC6 (PubMed:26030138)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30550790"}],"value":"(Microbial infection) The PAF1 complex interacts with Zika virus French Polynesia 10087PF/2013 non-structural protein 5/NS5 (PubMed:30550790). The interaction with viral NS5 proteins may reduce the antiviral immune response by inhibiting the recruitment of the PAF1 complex to interferon-stimulated genes, thus preventing their transcription (PubMed:30550790)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30550790"}],"value":"(Microbial infection) The PAF1 complex interacts with Dengue virus DENV2 16681 non-structural protein 5/NS5 (PubMed:30550790). The PAF1 complex interacts with Dengue virus DENV4 Dominica/814669/1981 non-structural protein 5/NS5 (PubMed:30550790). The interaction with viral NS5 proteins may reduce the antiviral immune response by inhibiting the recruitment of the PAF1 complex to interferon-stimulated genes, thus preventing their transcription (PubMed:30550790)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6PD62","intActId":"EBI-1019583"},"interactantTwo":{"uniProtKBAccession":"Q6P1J9","geneName":"CDC73","intActId":"EBI-930143"},"numberOfExperiments":25,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6PD62","intActId":"EBI-1019583"},"interactantTwo":{"uniProtKBAccession":"Q03164","geneName":"KMT2A","intActId":"EBI-591370"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6PD62","intActId":"EBI-1019583"},"interactantTwo":{"uniProtKBAccession":"Q8N7H5","geneName":"PAF1","intActId":"EBI-2607770"},"numberOfExperiments":29,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6PD62","intActId":"EBI-1019583"},"interactantTwo":{"uniProtKBAccession":"Q9GZS3","geneName":"SKIC8","intActId":"EBI-358545"},"numberOfExperiments":14,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"}],"value":"Nucleus speckle","id":"SL-0186"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8590280"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA09925.2","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1173,"modifier":"EXACT"}},"description":"RNA polymerase-associated protein CTR9 homolog","featureId":"PRO_0000231588"},{"type":"Repeat","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"TPR 1"},{"type":"Repeat","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"TPR 2"},{"type":"Repeat","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"TPR 3"},{"type":"Repeat","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"TPR 4"},{"type":"Repeat","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":268,"modifier":"EXACT"}},"description":"TPR 5"},{"type":"Repeat","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"TPR 6"},{"type":"Repeat","location":{"start":{"value":341,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"TPR 7"},{"type":"Repeat","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"TPR 8"},{"type":"Repeat","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":484,"modifier":"EXACT"}},"description":"TPR 9"},{"type":"Repeat","location":{"start":{"value":497,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"TPR 10"},{"type":"Repeat","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"TPR 11"},{"type":"Repeat","location":{"start":{"value":566,"modifier":"EXACT"},"end":{"value":598,"modifier":"EXACT"}},"description":"TPR 12"},{"type":"Repeat","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"TPR 13"},{"type":"Repeat","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"TPR 14"},{"type":"Repeat","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":714,"modifier":"EXACT"}},"description":"TPR 15"},{"type":"Repeat","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"TPR 16"},{"type":"Region","location":{"start":{"value":892,"modifier":"EXACT"},"end":{"value":1173,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":900,"modifier":"EXACT"},"end":{"value":912,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":917,"modifier":"EXACT"},"end":{"value":929,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":955,"modifier":"EXACT"},"end":{"value":964,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":980,"modifier":"EXACT"},"end":{"value":994,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1023,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1098,"modifier":"EXACT"},"end":{"value":1128,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1129,"modifier":"EXACT"},"end":{"value":1139,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1148,"modifier":"EXACT"},"end":{"value":1159,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1160,"modifier":"EXACT"},"end":{"value":1173,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":925,"modifier":"EXACT"},"end":{"value":925,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19367720"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":932,"modifier":"EXACT"},"end":{"value":932,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":941,"modifier":"EXACT"},"end":{"value":941,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":943,"modifier":"EXACT"},"end":{"value":943,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":970,"modifier":"EXACT"},"end":{"value":970,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1020,"modifier":"EXACT"},"end":{"value":1020,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1021,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"16964243"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1039,"modifier":"EXACT"},"end":{"value":1039,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"}]},{"type":"Modified residue","location":{"start":{"value":1041,"modifier":"EXACT"},"end":{"value":1041,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"}]},{"type":"Modified residue","location":{"start":{"value":1043,"modifier":"EXACT"},"end":{"value":1043,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"}]},{"type":"Modified residue","location":{"start":{"value":1081,"modifier":"EXACT"},"end":{"value":1081,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"}]},{"type":"Modified residue","location":{"start":{"value":1085,"modifier":"EXACT"},"end":{"value":1085,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62018"}]},{"type":"Modified residue","location":{"start":{"value":1087,"modifier":"EXACT"},"end":{"value":1087,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1097,"modifier":"EXACT"},"end":{"value":1097,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Modified residue","location":{"start":{"value":1102,"modifier":"EXACT"},"end":{"value":1102,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"}]},{"type":"Beta strand","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Beta strand","location":{"start":{"value":11,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OOP"}]},{"type":"Beta strand","location":{"start":{"value":16,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":53,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Beta strand","location":{"start":{"value":71,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OOP"}]},{"type":"Helix","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":145,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":298,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Turn","location":{"start":{"value":302,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":305,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Turn","location":{"start":{"value":318,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":334,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Beta strand","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":339,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OOP"}]},{"type":"Helix","location":{"start":{"value":342,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":370,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":391,"modifier":"EXACT"},"end":{"value":407,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":422,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Turn","location":{"start":{"value":423,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":427,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":445,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":448,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":483,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Turn","location":{"start":{"value":484,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":513,"modifier":"EXACT"},"end":{"value":526,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":544,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":547,"modifier":"EXACT"},"end":{"value":560,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":577,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":581,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Turn","location":{"start":{"value":596,"modifier":"EXACT"},"end":{"value":599,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":601,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Beta strand","location":{"start":{"value":644,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7OOP"}]},{"type":"Helix","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":663,"modifier":"EXACT"},"end":{"value":676,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":681,"modifier":"EXACT"},"end":{"value":693,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":697,"modifier":"EXACT"},"end":{"value":711,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Beta strand","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":715,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9EH2"}]},{"type":"Helix","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":730,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":733,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Beta strand","location":{"start":{"value":748,"modifier":"EXACT"},"end":{"value":750,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6GMH"}]},{"type":"Helix","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":798,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Turn","location":{"start":{"value":802,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]},{"type":"Helix","location":{"start":{"value":807,"modifier":"EXACT"},"end":{"value":889,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"9HVQ"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0802","category":"Domain","name":"TPR repeat"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0879","category":"Biological process","name":"Wnt signaling pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"8590280","citationType":"journal article","authors":["Nagase T.","Seki N.","Tanaka A.","Ishikawa K.","Nomura N."],"citationCrossReferences":[{"database":"PubMed","id":"8590280"},{"database":"DOI","id":"10.1093/dnares/2.4.167"}],"title":"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.","publicationDate":"1995","journal":"DNA Res.","firstPage":"167","lastPage":"174","volume":"2"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","TISSUE SPECIFICITY"],"referenceComments":[{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-E9N9MJ0FNBSGM","citationType":"submission","authors":["Ohara O.","Nagase T.","Kikuno R.","Nomura N."],"publicationDate":"AUG-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["SEQUENCE REVISION"]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16024656","citationType":"journal article","authors":["Zhu B.","Mandal S.S.","Pham A.D.","Zheng Y.","Erdjument-Bromage H.","Batra S.K.","Tempst P.","Reinberg D."],"citationCrossReferences":[{"database":"PubMed","id":"16024656"},{"database":"DOI","id":"10.1101/gad.1292105"}],"title":"The human PAF complex coordinates transcription with events downstream of RNA synthesis.","publicationDate":"2005","journal":"Genes Dev.","firstPage":"1668","lastPage":"1673","volume":"19"},"referencePositions":["FUNCTION","IDENTIFICATION IN THE PAF1 COMPLEX"]},{"referenceNumber":6,"citation":{"id":"16307923","citationType":"journal article","authors":["Zhu B.","Zheng Y.","Pham A.-D.","Mandal S.S.","Erdjument-Bromage H.","Tempst P.","Reinberg D."],"citationCrossReferences":[{"database":"PubMed","id":"16307923"},{"database":"DOI","id":"10.1016/j.molcel.2005.09.025"}],"title":"Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.","publicationDate":"2005","journal":"Mol. Cell","firstPage":"601","lastPage":"611","volume":"20"},"referencePositions":["FUNCTION"]},{"referenceNumber":7,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925; SER-941; SER-943 AND SER-970","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"16964243","citationType":"journal article","authors":["Beausoleil S.A.","Villen J.","Gerber S.A.","Rush J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"16964243"},{"database":"DOI","id":"10.1038/nbt1240"}],"title":"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.","publicationDate":"2006","journal":"Nat. Biotechnol.","firstPage":"1285","lastPage":"1292","volume":"24"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-941; SER-943; SER-1020 AND SER-1021","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"19367720","citationType":"journal article","authors":["Carrascal M.","Ovelleiro D.","Casas V.","Gay M.","Abian J."],"citationCrossReferences":[{"database":"PubMed","id":"19367720"},{"database":"DOI","id":"10.1021/pr800500r"}],"title":"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.","publicationDate":"2008","journal":"J. Proteome Res.","firstPage":"5167","lastPage":"5176","volume":"7"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"T-cell","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925 AND SER-970","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"19345177","citationType":"journal article","authors":["Ding L.","Paszkowski-Rogacz M.","Nitzsche A.","Slabicki M.M.","Heninger A.K.","de Vries I.","Kittler R.","Junqueira M.","Shevchenko A.","Schulz H.","Hubner N.","Doss M.X.","Sachinidis A.","Hescheler J.","Iacone R.","Anastassiadis K.","Stewart A.F.","Pisabarro M.T.","Caldarelli A.","Poser I.","Theis M.","Buchholz F."],"citationCrossReferences":[{"database":"PubMed","id":"19345177"},{"database":"DOI","id":"10.1016/j.stem.2009.03.009"}],"title":"A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.","publicationDate":"2009","journal":"Cell Stem Cell","firstPage":"403","lastPage":"415","volume":"4"},"referencePositions":["FUNCTION"]},{"referenceNumber":14,"citation":{"id":"19952111","citationType":"journal article","authors":["Chen Y.","Yamaguchi Y.","Tsugeno Y.","Yamamoto J.","Yamada T.","Nakamura M.","Hisatake K.","Handa H."],"citationCrossReferences":[{"database":"PubMed","id":"19952111"},{"database":"DOI","id":"10.1101/gad.1834709"}],"title":"DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.","publicationDate":"2009","journal":"Genes Dev.","firstPage":"2765","lastPage":"2777","volume":"23"},"referencePositions":["IDENTIFICATION IN THE PAF1 COMPLEX","FUNCTION OF THE PAF1 COMPLEX"]},{"referenceNumber":15,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925 AND SER-932","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"20541477","citationType":"journal article","authors":["Muntean A.G.","Tan J.","Sitwala K.","Huang Y.","Bronstein J.","Connelly J.A.","Basrur V.","Elenitoba-Johnson K.S.","Hess J.L."],"citationCrossReferences":[{"database":"PubMed","id":"20541477"},{"database":"DOI","id":"10.1016/j.ccr.2010.04.012"}],"title":"The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.","publicationDate":"2010","journal":"Cancer Cell","firstPage":"609","lastPage":"621","volume":"17"},"referencePositions":["FUNCTION OF THE PAF1 COMPLEX","INTERACTION WITH KMT2A"]},{"referenceNumber":17,"citation":{"id":"20178742","citationType":"journal article","authors":["Kim J.","Guermah M.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"20178742"},{"database":"DOI","id":"10.1016/j.cell.2009.12.050"}],"title":"The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.","publicationDate":"2010","journal":"Cell","firstPage":"491","lastPage":"503","volume":"140"},"referencePositions":["IDENTIFICATION IN THE PAF1 COMPLEX","COMPOSITION OF THE PAF1 COMPLEX","FUNCTION OF THE PAF1 COMPLEX"]},{"referenceNumber":18,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925; SER-941; SER-943 AND SER-970","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":19,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"21329879","citationType":"journal article","authors":["Nagaike T.","Logan C.","Hotta I.","Rozenblatt-Rosen O.","Meyerson M.","Manley J.L."],"citationCrossReferences":[{"database":"PubMed","id":"21329879"},{"database":"DOI","id":"10.1016/j.molcel.2011.01.022"}],"title":"Transcriptional activators enhance polyadenylation of mRNA precursors.","publicationDate":"2011","journal":"Mol. Cell","firstPage":"409","lastPage":"418","volume":"41"},"referencePositions":["FUNCTION","FUNCTION OF THE PAF1 COMPLEX"]},{"referenceNumber":21,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925; SER-941; SER-943; SER-970; SER-1020; SER-1021; SER-1097 AND SER-1102","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":22,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925 AND SER-970","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":23,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-925 AND SER-1087","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":24,"citation":{"id":"26030138","citationType":"journal article","authors":["Nicolai S.","Filippi S.","Caputo M.","Cipak L.","Gregan J.","Ammerer G.","Frontini M.","Willems D.","Prantera G.","Balajee A.S.","Proietti-De-Santis L."],"citationCrossReferences":[{"database":"PubMed","id":"26030138"},{"database":"DOI","id":"10.1371/journal.pone.0128558"}],"title":"Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.","publicationDate":"2015","journal":"PLoS ONE","firstPage":"E0128558","lastPage":"E0128558","volume":"10"},"referencePositions":["INTERACTION WITH ERCC6"]},{"referenceNumber":25,"citation":{"id":"30550790","citationType":"journal article","authors":["Shah P.S.","Link N.","Jang G.M.","Sharp P.P.","Zhu T.","Swaney D.L.","Johnson J.R.","Von Dollen J.","Ramage H.R.","Satkamp L.","Newton B.","Huettenhain R.","Petit M.J.","Baum T.","Everitt A.","Laufman O.","Tassetto M.","Shales M.","Stevenson E.","Iglesias G.N.","Shokat L.","Tripathi S.","Balasubramaniam V.","Webb L.G.","Aguirre S.","Willsey A.J.","Garcia-Sastre A.","Pollard K.S.","Cherry S.","Gamarnik A.V.","Marazzi I.","Taunton J.","Fernandez-Sesma A.","Bellen H.J.","Andino R.","Krogan N.J."],"citationCrossReferences":[{"database":"PubMed","id":"30550790"},{"database":"DOI","id":"10.1016/j.cell.2018.11.028"}],"title":"Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.","publicationDate":"2018","journal":"Cell","firstPage":"1931","lastPage":"1945","volume":"175"},"referencePositions":["INTERACTION WITH ZIKA VIRUS FRENCH POLYNESIA 10087PF/2013 NS5; DENGUE VIRUS DENV2 16681 NS5 AND DENGUE VIRUS DENV4 DOMINICA/814669/1981 NS5"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D63875","properties":[{"key":"ProteinId","value":"BAA09925.2"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471064","properties":[{"key":"ProteinId","value":"EAW68557.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471064","properties":[{"key":"ProteinId","value":"EAW68558.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC058914","properties":[{"key":"ProteinId","value":"AAH58914.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS7805.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_055448.1","properties":[{"key":"NucleotideSequenceId","value":"NM_014633.5"}]},{"database":"PDB","id":"5ZYQ","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.53 A"},{"key":"Chains","value":"A=1-249"}]},{"database":"PDB","id":"6GMH","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"Q=301-1173"}]},{"database":"PDB","id":"6TED","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"7OOP","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"S=1-1173"}]},{"database":"PDB","id":"7OPC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"S=1-1173"}]},{"database":"PDB","id":"7OPD","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"S=1-1173"}]},{"database":"PDB","id":"7UNC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"7UND","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.00 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"8A3Y","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.30 A"},{"key":"Chains","value":"Q/U=1-1173"}]},{"database":"PDB","id":"9EGX","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9EGY","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9EGZ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.90 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9EH0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.60 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9EH1","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"Q=3-892"}]},{"database":"PDB","id":"9EH2","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"3.10 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9HVQ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9MLC","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9RTT","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.01 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9RZE","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"8.53 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9S0U","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.72 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDB","id":"9S3G","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.40 A"},{"key":"Chains","value":"Q=1-1173"}]},{"database":"PDBsum","id":"5ZYQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6GMH","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6TED","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OOP","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OPC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7OPD","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UNC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"7UND","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8A3Y","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EGX","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EGY","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EGZ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EH0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EH1","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9EH2","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9HVQ","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9MLC","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RTT","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9RZE","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9S0U","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9S3G","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-0031","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-10480","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13010","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13015","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-13016","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26620","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-26621","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48039","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48040","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48041","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48042","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48043","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48044","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-48353","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-52443","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54251","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54401","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54425","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-54537","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"115004","properties":[{"key":"Interactions","value":"284"}]},{"database":"ComplexPortal","id":"CPX-2381","properties":[{"key":"EntryName","value":"PAF1 complex"}]},{"database":"CORUM","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-31693N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6PD62","properties":[{"key":"Number of interactors","value":"3477"}]},{"database":"IntAct","id":"Q6PD62","properties":[{"key":"Interactions","value":"164"}]},{"database":"MINT","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-CTR9","properties":[{"key":"Evidences","value":"3 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000355013","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL5724759","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q6PD62","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CTR9","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74758318","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000355013","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"67068","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"24416","properties":[{"key":"antibodies","value":"192 antibodies from 27 providers"}]},{"database":"DNASU","id":"9646","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000361367.7","properties":[{"key":"ProteinId","value":"ENSP00000355013.2"},{"key":"GeneId","value":"ENSG00000198730.10"}]},{"database":"Ensembl","id":"ENST00000715696.1","properties":[{"key":"ProteinId","value":"ENSP00000520504.1"},{"key":"GeneId","value":"ENSG00000198730.10"}]},{"database":"GeneID","id":"9646","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:9646","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000361367.7","properties":[{"key":"ProteinId","value":"ENSP00000355013.2"},{"key":"RefSeqNucleotideId","value":"NM_014633.5"},{"key":"RefSeqProteinId","value":"NP_055448.1"}]},{"database":"UCSC","id":"uc001mja.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:16850","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134896774","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"9646","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"9646","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CTR9","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:16850","properties":[{"key":"GeneName","value":"CTR9"}]},{"database":"HPA","id":"ENSG00000198730","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"CTR9","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"609366","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000198730","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"654","properties":[{"key":"Disease","value":"Nephroblastoma"}]},{"database":"Orphanet","id":"528084","properties":[{"key":"Disease","value":"Non-specific syndromic intellectual disability"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000198730","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2002","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000005097","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_006386_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EHWLTIA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"343875at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6PD62","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-112382","properties":[{"key":"PathwayName","value":"Formation of RNA Pol II elongation complex"}]},{"database":"Reactome","id":"R-HSA-674695","properties":[{"key":"PathwayName","value":"RNA Polymerase II Pre-transcription Events"}]},{"database":"Reactome","id":"R-HSA-75955","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Elongation"}]},{"database":"Reactome","id":"R-HSA-8866654","properties":[{"key":"PathwayName","value":"E3 ubiquitin ligases ubiquitinate target proteins"}]},{"database":"Reactome","id":"R-HSA-9920588","properties":[{"key":"PathwayName","value":"Dengue virus activates/modulates innate and adaptive immune responses"}]},{"database":"Reactome","id":"R-HSA-9943411","properties":[{"key":"PathwayName","value":"CHD1 and CHD2 subfamily"}]},{"database":"SignaLink","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000198730","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"9646","properties":[{"key":"hits","value":"668 hits in 1175 CRISPR screens"}]},{"database":"ChiTaRS","id":"CTR9","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"CTR9","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"9646","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6PD62","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q6PD62","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q6PD62","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000198730","properties":[{"key":"ExpressionPatterns","value":"Expressed in corpus epididymis and 211 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6PD62","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016593","properties":[{"key":"GoTerm","value":"C:Cdc73/Paf1 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16307923"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20178742"}]},{"database":"GO","id":"GO:0000791","properties":[{"key":"GoTerm","value":"C:euchromatin"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016607","properties":[{"key":"GoTerm","value":"C:nuclear speck"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20178742"}]},{"database":"GO","id":"GO:0000993","properties":[{"key":"GoTerm","value":"F:RNA polymerase II complex binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042169","properties":[{"key":"GoTerm","value":"F:SH2 domain binding"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0007259","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway via JAK-STAT"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071222","properties":[{"key":"GoTerm","value":"P:cellular response to lipopolysaccharide"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0006325","properties":[{"key":"GoTerm","value":"P:chromatin organization"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0001711","properties":[{"key":"GoTerm","value":"P:endodermal cell fate commitment"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070102","properties":[{"key":"GoTerm","value":"P:interleukin-6-mediated signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045638","properties":[{"key":"GoTerm","value":"P:negative regulation of myeloid cell differentiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20541477"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16307923"}]},{"database":"GO","id":"GO:0019827","properties":[{"key":"GoTerm","value":"P:stem cell population maintenance"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19345177"}]},{"database":"GO","id":"GO:0006368","properties":[{"key":"GoTerm","value":"P:transcription elongation by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20178742"}]},{"database":"FunFam","id":"1.25.40.10:FF:000089","properties":[{"key":"EntryName","value":"CTR9 homolog, Paf1/RNA polymerase II complex component"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.10:FF:000162","properties":[{"key":"EntryName","value":"CTR9 homolog, Paf1/RNA polymerase II complex component"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.10:FF:001026","properties":[{"key":"EntryName","value":"CTR9 homolog, Paf1/RNA polymerase II complex component"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.10","properties":[{"key":"EntryName","value":"Tetratricopeptide repeat domain"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR031101","properties":[{"key":"EntryName","value":"Ctr9"}]},{"database":"InterPro","id":"IPR011990","properties":[{"key":"EntryName","value":"TPR-like_helical_dom_sf"}]},{"database":"InterPro","id":"IPR019734","properties":[{"key":"EntryName","value":"TPR_rpt"}]},{"database":"PANTHER","id":"PTHR14027","properties":[{"key":"EntryName","value":"RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14027:SF2","properties":[{"key":"EntryName","value":"RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13374","properties":[{"key":"EntryName","value":"TPR_10"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14559","properties":[{"key":"EntryName","value":"TPR_19"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF13181","properties":[{"key":"EntryName","value":"TPR_8"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00028","properties":[{"key":"EntryName","value":"TPR"},{"key":"MatchStatus","value":"10"}]},{"database":"SUPFAM","id":"SSF81901","properties":[{"key":"EntryName","value":"HCP-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48452","properties":[{"key":"EntryName","value":"TPR-like"},{"key":"MatchStatus","value":"3"}]},{"database":"PROSITE","id":"PS50005","properties":[{"key":"EntryName","value":"TPR"},{"key":"MatchStatus","value":"10"}]},{"database":"PROSITE","id":"PS50293","properties":[{"key":"EntryName","value":"TPR_REGION"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSRGSIEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKNKDNKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSKVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQGSGNESEPEGSNNEASDRGSEHGSDDSD","length":1173,"molWeight":133502,"crc64":"4B5AC22A5C5573C6","md5":"07FB12F8B31487A6F3A0B2C53215D79A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":3,"INTERACTION":4,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Repeat":16,"Region":1,"Compositional bias":9,"Modified residue":15,"Beta strand":8,"Helix":44,"Turn":6},"uniParcId":"UPI000006F32A"}}