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Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (PubMed:22936354, PubMed:23021219). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). 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In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22936354"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23021219"}],"value":"Mice are viable and fertile, and display no major morphological defects. They exhibit deficiencies in Ca(2+)-dependent phospholipid scramblase activity in platelets and defects in blood coagulation (PubMed:23021219). They also show reduced skeleton size and skeletal deformities"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. 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