{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6NVU6","secondaryAccessions":["A0A5F9ZGY7","A4D2E4","A8K8V2","B6ZDG6","Q9BXP6"],"uniProtkbId":"UFSP1_HUMAN","entryAudit":{"firstPublicDate":"2007-03-20","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2024-07-24","entryVersion":135,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Ufm1-specific protease 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35926457"}],"value":"UfSP1"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35926457"}],"value":"3.4.22.-"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"35926457"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:33821"}],"value":"UFSP1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35926457"}],"value":"Thiol-dependent isopeptidase that specifically mediate the processing of UFM1 precursors as well as the deconjugation of UFM1 from target proteins (PubMed:35525273, PubMed:35926457). Mainly responsible for the maturation of the UFM1 precursor, a prerequisite for conjugation reactions (PubMed:35525273, PubMed:35926457)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q5SWW7","geneName":"C10orf55","intActId":"EBI-12809220"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9UHD4","geneName":"CIDEB","intActId":"EBI-7062247"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q96AQ7","geneName":"CIDEC","intActId":"EBI-14151404"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9Y2V7","geneName":"COG6","intActId":"EBI-3866319"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q02930-3","geneName":"CREB5","intActId":"EBI-10192698"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"P33240","geneName":"CSTF2","intActId":"EBI-711360"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q8WU58","geneName":"FAM222B","intActId":"EBI-2807642"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9NW38","geneName":"FANCL","intActId":"EBI-2339898"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"O75593","geneName":"FOXH1","intActId":"EBI-1759806"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q12951-2","geneName":"FOXI1","intActId":"EBI-12018822"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q8IVS8","geneName":"GLYCTK","intActId":"EBI-748515"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9Y4H4","geneName":"GPSM3","intActId":"EBI-347538"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"P35680","geneName":"HNF1B","intActId":"EBI-2798841"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"P31274","geneName":"HOXC9","intActId":"EBI-1779423"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9ULV5-2","geneName":"HSF4","intActId":"EBI-12056251"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q0VD86","geneName":"INCA1","intActId":"EBI-6509505"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q3LI76","geneName":"KRTAP15-1","intActId":"EBI-11992140"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q14847-2","geneName":"LASP1","intActId":"EBI-9088686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q8IXL7-2","geneName":"MSRB3","intActId":"EBI-10699187"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q8TDC0","geneName":"MYOZ3","intActId":"EBI-5662487"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"P78337","geneName":"PITX1","intActId":"EBI-748265"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q99697-2","geneName":"PITX2","intActId":"EBI-12138495"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q7Z3K3","geneName":"POGZ","intActId":"EBI-1389308"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"P78424","geneName":"POU6F2","intActId":"EBI-12029004"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"O75360","geneName":"PROP1","intActId":"EBI-9027467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q6ZRY4","geneName":"RBPMS2","intActId":"EBI-11987469"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9BVN2","geneName":"RUSC1","intActId":"EBI-6257312"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q92922","geneName":"SMARCC1","intActId":"EBI-355653"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"P09234","geneName":"SNRPC","intActId":"EBI-766589"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9NZD8","geneName":"SPG21","intActId":"EBI-742688"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"O15119","geneName":"TBX3","intActId":"EBI-3452216"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9NQB0-10","geneName":"TCF7L2","intActId":"EBI-11746252"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"O43711","geneName":"TLX3","intActId":"EBI-3939165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9UHD9","geneName":"UBQLN2","intActId":"EBI-947187"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q08AM6","geneName":"VAC14","intActId":"EBI-2107455"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9UIW0","geneName":"VAX2","intActId":"EBI-12090999"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"A8MV65-2","geneName":"VGLL3","intActId":"EBI-11957216"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"A5D8V6","geneName":"VPS37C","intActId":"EBI-2559305"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q9NZC7-5","geneName":"WWOX","intActId":"EBI-12040603"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NVU6","intActId":"EBI-12068150"},"interactantTwo":{"uniProtKBAccession":"Q15915","geneName":"ZIC1","intActId":"EBI-11963196"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35926457"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the peptidase C78 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35926457"}],"value":"UFSP1 initiates at a non-canonical GUG codon (PubMed:35525273, PubMed:35926457). Was initially thought to initiate from Met-77 and constitute a inactive isopeptidase that lacks a functional protease domain (PubMed:35525273, PubMed:35926457)"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH67904.1","note":"Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAK21004.1","note":"Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAF85156.1","note":"Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"EAL23814.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"Ufm1-specific protease 1","featureId":"PRO_0000280360"},{"type":"Active site","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"35525273"}]},{"type":"Active site","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":167,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CZP0"}]},{"type":"Active site","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CZP0"}]},{"type":"Natural variant","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"in dbSNP:rs12666989","featureCrossReferences":[{"database":"dbSNP","id":"rs12666989"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12690205"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"}],"featureId":"VAR_031125","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Mutagenesis","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Abolished isopeptidase activity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35525273"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0645","category":"Molecular function","name":"Protease"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0788","category":"Molecular function","name":"Thiol protease"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"11239002","citationType":"journal article","authors":["Wilson M.D.","Riemer C.","Martindale D.W.","Schnupf P.","Boright A.P.","Cheung T.L.","Hardy D.M.","Schwartz S.","Scherer S.W.","Tsui L.-C.","Miller W.","Koop B.F."],"citationCrossReferences":[{"database":"PubMed","id":"11239002"},{"database":"DOI","id":"10.1093/nar/29.6.1352"}],"title":"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.","publicationDate":"2001","journal":"Nucleic Acids Res.","firstPage":"1352","lastPage":"1365","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT VAL-123"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12690205","citationType":"journal article","authors":["Scherer S.W.","Cheung J.","MacDonald J.R.","Osborne L.R.","Nakabayashi K.","Herbrick J.-A.","Carson A.R.","Parker-Katiraee L.","Skaug J.","Khaja R.","Zhang J.","Hudek A.K.","Li M.","Haddad M.","Duggan G.E.","Fernandez B.A.","Kanematsu E.","Gentles S.","Christopoulos C.C.","Choufani S.","Kwasnicka D.","Zheng X.H.","Lai Z.","Nusskern D.R.","Zhang Q.","Gu Z.","Lu F.","Zeesman S.","Nowaczyk M.J.","Teshima I.","Chitayat D.","Shuman C.","Weksberg R.","Zackai E.H.","Grebe T.A.","Cox S.R.","Kirkpatrick S.J.","Rahman N.","Friedman J.M.","Heng H.H.Q.","Pelicci P.G.","Lo-Coco F.","Belloni E.","Shaffer L.G.","Pober B.","Morton C.C.","Gusella J.F.","Bruns G.A.P.","Korf B.R.","Quade B.J.","Ligon A.H.","Ferguson H.","Higgins A.W.","Leach N.T.","Herrick S.R.","Lemyre E.","Farra C.G.","Kim H.-G.","Summers A.M.","Gripp K.W.","Roberts W.","Szatmari P.","Winsor E.J.T.","Grzeschik K.-H.","Teebi A.","Minassian B.A.","Kere J.","Armengol L.","Pujana M.A.","Estivill X.","Wilson M.D.","Koop B.F.","Tosi S.","Moore G.E.","Boright A.P.","Zlotorynski E.","Kerem B.","Kroisel P.M.","Petek E.","Oscier D.G.","Mould S.J.","Doehner H.","Doehner K.","Rommens J.M.","Vincent J.B.","Venter J.C.","Li P.W.","Mural R.J.","Adams M.D.","Tsui L.-C."],"citationCrossReferences":[{"database":"PubMed","id":"12690205"},{"database":"DOI","id":"10.1126/science.1083423"}],"title":"Human chromosome 7: DNA sequence and biology.","publicationDate":"2003","journal":"Science","firstPage":"767","lastPage":"772","volume":"300"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","VARIANT VAL-123"]},{"referenceNumber":4,"citation":{"id":"12853948","citationType":"journal article","authors":["Hillier L.W.","Fulton R.S.","Fulton L.A.","Graves T.A.","Pepin K.H.","Wagner-McPherson C.","Layman D.","Maas J.","Jaeger S.","Walker R.","Wylie K.","Sekhon M.","Becker M.C.","O'Laughlin M.D.","Schaller M.E.","Fewell G.A.","Delehaunty K.D.","Miner T.L.","Nash W.E.","Cordes M.","Du H.","Sun H.","Edwards J.","Bradshaw-Cordum H.","Ali J.","Andrews S.","Isak A.","Vanbrunt A.","Nguyen C.","Du F.","Lamar B.","Courtney L.","Kalicki J.","Ozersky P.","Bielicki L.","Scott K.","Holmes A.","Harkins R.","Harris A.","Strong C.M.","Hou S.","Tomlinson C.","Dauphin-Kohlberg S.","Kozlowicz-Reilly A.","Leonard S.","Rohlfing T.","Rock S.M.","Tin-Wollam A.-M.","Abbott A.","Minx P.","Maupin R.","Strowmatt C.","Latreille P.","Miller N.","Johnson D.","Murray J.","Woessner J.P.","Wendl M.C.","Yang S.-P.","Schultz B.R.","Wallis J.W.","Spieth J.","Bieri T.A.","Nelson J.O.","Berkowicz N.","Wohldmann P.E.","Cook L.L.","Hickenbotham M.T.","Eldred J.","Williams D.","Bedell J.A.","Mardis E.R.","Clifton S.W.","Chissoe S.L.","Marra M.A.","Raymond C.","Haugen E.","Gillett W.","Zhou Y.","James R.","Phelps K.","Iadanoto S.","Bubb K.","Simms E.","Levy R.","Clendenning J.","Kaul R.","Kent W.J.","Furey T.S.","Baertsch R.A.","Brent M.R.","Keibler E.","Flicek P.","Bork P.","Suyama M.","Bailey J.A.","Portnoy M.E.","Torrents D.","Chinwalla A.T.","Gish W.R.","Eddy S.R.","McPherson J.D.","Olson M.V.","Eichler E.E.","Green E.D.","Waterston R.H.","Wilson R.K."],"citationCrossReferences":[{"database":"PubMed","id":"12853948"},{"database":"DOI","id":"10.1038/nature01782"}],"title":"The DNA sequence of human chromosome 7.","publicationDate":"2003","journal":"Nature","firstPage":"157","lastPage":"164","volume":"424"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"35926457","citationType":"journal article","authors":["Millrine D.","Cummings T.","Matthews S.P.","Peter J.J.","Magnussen H.M.","Lange S.M.","Macartney T.","Lamoliatte F.","Knebel A.","Kulathu Y."],"citationCrossReferences":[{"database":"PubMed","id":"35926457"},{"database":"DOI","id":"10.1016/j.celrep.2022.111168"}],"title":"Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.","publicationDate":"2022","journal":"Cell Rep.","firstPage":"111168","lastPage":"111168","volume":"40"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","SUBCELLULAR LOCATION","IDENTIFICATION BY MASS SPECTROMETRY"]},{"referenceNumber":7,"citation":{"id":"35525273","citationType":"journal article","authors":["Liang Q.","Jin Y.","Xu S.","Zhou J.","Mao J.","Ma X.","Wang M.","Cong Y.S."],"citationCrossReferences":[{"database":"PubMed","id":"35525273"},{"database":"DOI","id":"10.1016/j.jbc.2022.102016"}],"title":"Human UFSP1 translated from an upstream near-cognate initiation codon functions as an active UFM1-specific protease.","publicationDate":"2022","journal":"J. Biol. Chem.","firstPage":"102016","lastPage":"102016","volume":"298"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","ACTIVE SITE","IDENTIFICATION BY MASS SPECTROMETRY","MUTAGENESIS OF CYS-45"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF312032","properties":[{"key":"ProteinId","value":"AAK21004.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK292467","properties":[{"key":"ProteinId","value":"BAF85156.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH236956","properties":[{"key":"ProteinId","value":"EAL23814.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC011895","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC067904","properties":[{"key":"ProteinId","value":"AAH67904.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001015072.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001015072.4"}]},{"database":"RefSeq","id":"NP_001417873.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001430944.2"}]},{"database":"AlphaFoldDB","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"135544","properties":[{"key":"Interactions","value":"55"}]},{"database":"FunCoup","id":"Q6NVU6","properties":[{"key":"Number of interactors","value":"28"}]},{"database":"IntAct","id":"Q6NVU6","properties":[{"key":"Interactions","value":"40"}]},{"database":"STRING","id":"9606.ENSP00000373413","properties":[{"key":"Description","value":"-"}]},{"database":"MEROPS","id":"C78.001","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"UFSP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"296452856","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000373413","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"66720","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"16700","properties":[{"key":"antibodies","value":"25 antibodies from 13 providers"}]},{"database":"DNASU","id":"402682","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000672365.3","properties":[{"key":"ProteinId","value":"ENSP00000499910.2"},{"key":"GeneId","value":"ENSG00000176125.7"}]},{"database":"GeneID","id":"402682","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:402682","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000672365.3","properties":[{"key":"ProteinId","value":"ENSP00000499910.2"},{"key":"RefSeqNucleotideId","value":"NM_001430944.2"},{"key":"RefSeqProteinId","value":"NP_001417873.1"}]},{"database":"UCSC","id":"uc003uxc.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:33821","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162408522","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"402682","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"402682","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"UFSP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:33821","properties":[{"key":"GeneName","value":"UFSP1"}]},{"database":"HPA","id":"ENSG00000176125","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"611481","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000176125","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000176125","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2433","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000162936","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_1815130_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AISWIIN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"417506at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6NVU6","properties":[{"key":"Number of GO annotations","value":"1 GO annotation based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000176125","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"402682","properties":[{"key":"hits","value":"20 hits in 1148 CRISPR screens"}]},{"database":"GenomeRNAi","id":"402682","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6NVU6","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q6NVU6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q6NVU6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000176125","properties":[{"key":"ExpressionPatterns","value":"Expressed in primordial germ cell in gonad and 93 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35926457"}]},{"database":"GO","id":"GO:0008234","properties":[{"key":"GoTerm","value":"F:cysteine-type peptidase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35926457"}]},{"database":"GO","id":"GO:0071567","properties":[{"key":"GoTerm","value":"F:deUFMylase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35926457"}]},{"database":"GO","id":"GO:0051604","properties":[{"key":"GoTerm","value":"P:protein maturation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35926457"}]},{"database":"GO","id":"GO:0071569","properties":[{"key":"GoTerm","value":"P:protein ufmylation"},{"key":"GoEvidenceType","value":"IDA:UniProt"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35525273"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35926457"}]},{"database":"Gene3D","id":"3.90.70.130","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012462","properties":[{"key":"EntryName","value":"UFSP1/2_DUB_cat"}]},{"database":"PANTHER","id":"PTHR48153:SF3","properties":[{"key":"EntryName","value":"INACTIVE UFM1-SPECIFIC PROTEASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48153","properties":[{"key":"EntryName","value":"UFM1-SPECIFIC PROTEASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07910","properties":[{"key":"EntryName","value":"Peptidase_C78"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEPLRDVHVGLSPPSRGPVRLALLSGHYLYYHYGCDGLDDRGWGCGYRTLQTLCSWPEGQPAGVPGLAAVQAALEDMGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLHGELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPSELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD","length":218,"molWeight":23253,"crc64":"C9CB6404D95B1BEF","md5":"4C345D8D5E639C0900D7353A62F53EEF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":40,"SUBCELLULAR LOCATION":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":4},"countByFeatureType":{"Chain":1,"Active site":3,"Natural variant":1,"Mutagenesis":1},"uniParcId":"UPI0018BF1B9D"}}