{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6NTE8","secondaryAccessions":["B5MD09","E9PAK6","Q7Z3D8","Q9BUC1","Q9UN54"],"uniProtkbId":"MRNIP_HUMAN","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2008-11-25","entryVersion":147,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30817"}],"value":"MRN complex-interacting protein"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"27568553"}],"value":"MRN-interacting protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:30817"}],"value":"MRNIP"},"synonyms":[{"value":"C5orf45"}]}],"comments":[{"texts":[{"value":"Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"value":"Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive (PubMed:27568553). Interacts with MRE11 (PubMed:27568553). Interacts with NBN (PubMed:27568553). Interacts with RAD50 (PubMed:27568553)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"Q9BVJ7","geneName":"DUSP23","intActId":"EBI-724940"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"Q5JVL4","geneName":"EFHC1","intActId":"EBI-743105"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"P60228","geneName":"EIF3E","intActId":"EBI-347740"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"Q9H0I2","geneName":"ENKD1","intActId":"EBI-744099"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"P61970","geneName":"NUTF2","intActId":"EBI-591778"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"Q9UBU9","geneName":"NXF1","intActId":"EBI-398874"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"P61925","geneName":"PKIA","intActId":"EBI-2682139"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6NTE8","intActId":"EBI-2857471"},"interactantTwo":{"uniProtKBAccession":"P20618","geneName":"PSMB1","intActId":"EBI-372273"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"value":"Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"value":"Nucleus, nucleoplasm","id":"SL-0190"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q6NTE8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q6NTE8-2"],"sequenceIds":["VSP_032560","VSP_032561","VSP_032562"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q6NTE8-3"],"sequenceIds":["VSP_047227"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"value":"Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation on Ser-115 is necessary for its nuclear retention"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MRNIP family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAD51611.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"CAD97932.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"MRN complex-interacting protein","featureId":"PRO_0000326119"},{"type":"Region","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Necessary for the association with the MRN complex","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}]},{"type":"Region","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Nuclear localization signal (NLS)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}]},{"type":"Compositional bias","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":202,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}]},{"type":"Modified residue","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_032560","alternativeSequence":{"originalSequence":"MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQ","alternativeSequences":["MQSARAWLPGDCTSRDGVASAFSGATLLQLPPLPGAPGKKECQVDMQSLWREAVLFAEFPRHGAPASELPVPSGSEMDGAESGK"]}},{"type":"Alternative sequence","location":{"start":{"value":43,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_047227","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":222,"modifier":"EXACT"},"end":{"value":229,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_032561","alternativeSequence":{"originalSequence":"VTATSSKW","alternativeSequences":["DGYKEILF"]}},{"type":"Alternative sequence","location":{"start":{"value":230,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"17974005"}],"featureId":"VSP_032562","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"in dbSNP:rs1650893","featureCrossReferences":[{"database":"dbSNP","id":"rs1650893"}],"featureId":"VAR_054030","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"in dbSNP:rs1650893","featureCrossReferences":[{"database":"dbSNP","id":"rs1650893"}],"featureId":"VAR_039990","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in dbSNP:rs248248","featureCrossReferences":[{"database":"dbSNP","id":"rs248248"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_039991","alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":231,"modifier":"EXACT"}},"description":"in dbSNP:rs10277","featureCrossReferences":[{"database":"dbSNP","id":"rs10277"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"featureId":"VAR_039992","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":100,"modifier":"EXACT"},"end":{"value":100,"modifier":"EXACT"}},"description":"Does not affect nuclear localization. Decreases weakly the association with the MRN complex. Reduces phosphorylation; when associated with A-115 and A-143.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Reduces nuclear localization and increases DNA damage accumulation. Decreases weakly the association with the MRN complex. Reduces phosphorylation; when associated with A-100 and A-143.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"Does not affect nuclear localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["D"]}},{"type":"Mutagenesis","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with 148-A--A-151 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Reduces phosphorylation; when associated with A-100 and A-115.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Decreases nuclear localization. Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with A-141 and A-154.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"RKRK","alternativeSequences":["AAAA"]}},{"type":"Mutagenesis","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with A-141 and 148-A--A-151.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"Reduces the association with the MRN complex.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27568553"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"},"sequence":"Q6NTE8-3"},"description":"in Ref. 3; BC050714","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0227","category":"Biological process","name":"DNA damage"},{"id":"KW-0234","category":"Biological process","name":"DNA repair"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Endometrium","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15372022","citationType":"journal article","authors":["Schmutz J.","Martin J.","Terry A.","Couronne O.","Grimwood J.","Lowry S.","Gordon L.A.","Scott D.","Xie G.","Huang W.","Hellsten U.","Tran-Gyamfi M.","She X.","Prabhakar S.","Aerts A.","Altherr M.","Bajorek E.","Black S.","Branscomb E.","Caoile C.","Challacombe J.F.","Chan Y.M.","Denys M.","Detter J.C.","Escobar J.","Flowers D.","Fotopulos D.","Glavina T.","Gomez M.","Gonzales E.","Goodstein D.","Grigoriev I.","Groza M.","Hammon N.","Hawkins T.","Haydu L.","Israni S.","Jett J.","Kadner K.","Kimball H.","Kobayashi A.","Lopez F.","Lou Y.","Martinez D.","Medina C.","Morgan J.","Nandkeshwar R.","Noonan J.P.","Pitluck S.","Pollard M.","Predki P.","Priest J.","Ramirez L.","Retterer J.","Rodriguez A.","Rogers S.","Salamov A.","Salazar A.","Thayer N.","Tice H.","Tsai M.","Ustaszewska A.","Vo N.","Wheeler J.","Wu K.","Yang J.","Dickson M.","Cheng J.-F.","Eichler E.E.","Olsen A.","Pennacchio L.A.","Rokhsar D.S.","Richardson P.","Lucas S.M.","Myers R.M.","Rubin E.M."],"citationCrossReferences":[{"database":"PubMed","id":"15372022"},{"database":"DOI","id":"10.1038/nature02919"}],"title":"The DNA sequence and comparative analysis of human chromosome 5.","publicationDate":"2004","journal":"Nature","firstPage":"268","lastPage":"274","volume":"431"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-343 (ISOFORM 3)","VARIANTS GLY-154 AND ARG-231"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-584R6C84S8RLT","citationType":"submission","authors":["Zhang W.","Yuan Z.","Wan T.","Cao X."],"publicationDate":"MAY-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 113-343 (ISOFORM 1)","VARIANT ARG-231"]},{"referenceNumber":5,"citation":{"id":"27568553","citationType":"journal article","authors":["Staples C.J.","Barone G.","Myers K.N.","Ganesh A.","Gibbs-Seymour I.","Patil A.A.","Beveridge R.D.","Daye C.","Beniston R.","Maslen S.","Ahel I.","Skehel J.M.","Collis S.J."],"citationCrossReferences":[{"database":"PubMed","id":"27568553"},{"database":"DOI","id":"10.1016/j.celrep.2016.07.087"}],"title":"MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.","publicationDate":"2016","journal":"Cell Rep.","firstPage":"2565","lastPage":"2575","volume":"16"},"referencePositions":["FUNCTION","PHOSPHORYLATION AT SER-100 AND SER-115","ASSOCIATION WITH THE MRN COMPLEX","INTERACTION WITH MRE11; NBN AND RAD50","SUBCELLULAR LOCATION","REGION","MUTAGENESIS OF SER-100; SER-115; ARG-141; SER-143; 148-ARG--LYS-151; ARG-154 AND 213-LYS--ARG-237"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BX537968","properties":[{"key":"ProteinId","value":"CAD97932.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC008393","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC002739","properties":[{"key":"ProteinId","value":"AAH02739.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC050714","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC069051","properties":[{"key":"ProteinId","value":"AAH69051.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF153685","properties":[{"key":"ProteinId","value":"AAD51611.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS34318.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6NTE8-3"},{"database":"CCDS","id":"CCDS34319.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6NTE8-1"},{"database":"RefSeq","id":"NP_001017987.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001017987.3"}],"isoformId":"Q6NTE8-3"},{"database":"RefSeq","id":"NP_057259.2","properties":[{"key":"NucleotideSequenceId","value":"NM_016175.4"}],"isoformId":"Q6NTE8-1"},{"database":"AlphaFoldDB","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"119333","properties":[{"key":"Interactions","value":"40"}]},{"database":"CORUM","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6NTE8","properties":[{"key":"Number of interactors","value":"1183"}]},{"database":"IntAct","id":"Q6NTE8","properties":[{"key":"Interactions","value":"14"}]},{"database":"MINT","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000292586","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MRNIP","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"215273989","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000292586","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19034","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"66668","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6NTE8-1"},{"database":"ProteomicsDB","id":"66669","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6NTE8-2"},{"database":"Pumba","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"62814","properties":[{"key":"antibodies","value":"105 antibodies from 13 providers"}]},{"database":"DNASU","id":"51149","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000292586.11","properties":[{"key":"ProteinId","value":"ENSP00000292586.6"},{"key":"GeneId","value":"ENSG00000161010.16"}],"isoformId":"Q6NTE8-1"},{"database":"Ensembl","id":"ENST00000376931.6","properties":[{"key":"ProteinId","value":"ENSP00000366130.2"},{"key":"GeneId","value":"ENSG00000161010.16"}],"isoformId":"Q6NTE8-3"},{"database":"Ensembl","id":"ENST00000639632.2","properties":[{"key":"ProteinId","value":"ENSP00000491991.1"},{"key":"GeneId","value":"ENSG00000283918.2"}],"isoformId":"Q6NTE8-1"},{"database":"Ensembl","id":"ENST00000640658.1","properties":[{"key":"ProteinId","value":"ENSP00000491128.1"},{"key":"GeneId","value":"ENSG00000283918.2"}],"isoformId":"Q6NTE8-3"},{"database":"GeneID","id":"51149","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:51149","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000292586.11","properties":[{"key":"ProteinId","value":"ENSP00000292586.6"},{"key":"RefSeqNucleotideId","value":"NM_016175.4"},{"key":"RefSeqProteinId","value":"NP_057259.2"}]},{"database":"UCSC","id":"uc003mla.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q6NTE8-1"},{"database":"AGR","id":"HGNC:30817","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162380286","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"51149","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"51149","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MRNIP","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:30817","properties":[{"key":"GeneName","value":"MRNIP"}]},{"database":"HPA","id":"ENSG00000161010","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"617154","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000161010","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000161010","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S8YD","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000006124","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_068693_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GHQQAEN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5960226at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6NTE8","properties":[{"key":"Number of GO annotations","value":"3 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000161010","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"51149","properties":[{"key":"hits","value":"12 hits in 1128 CRISPR screens"}]},{"database":"ChiTaRS","id":"C5orf45","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"51149","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6NTE8","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q6NTE8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q6NTE8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000161010","properties":[{"key":"ExpressionPatterns","value":"Expressed in cerebellar hemisphere and 107 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6NTE8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0006974","properties":[{"key":"GoTerm","value":"P:DNA damage response"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0007095","properties":[{"key":"GoTerm","value":"P:mitotic G2 DNA damage checkpoint signaling"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:1905168","properties":[{"key":"GoTerm","value":"P:positive regulation of double-strand break repair via homologous recombination"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0045860","properties":[{"key":"GoTerm","value":"P:positive regulation of protein kinase activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0071168","properties":[{"key":"GoTerm","value":"P:protein localization to chromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:2001032","properties":[{"key":"GoTerm","value":"P:regulation of double-strand break repair via nonhomologous end joining"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27568553"}]},{"database":"GO","id":"GO:0010212","properties":[{"key":"GoTerm","value":"P:response to ionizing radiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27568553"}]},{"database":"InterPro","id":"IPR032739","properties":[{"key":"EntryName","value":"MRNIP"}]},{"database":"InterPro","id":"IPR049472","properties":[{"key":"EntryName","value":"MRNIP_N"}]},{"database":"PANTHER","id":"PTHR15863","properties":[{"key":"EntryName","value":"MRN COMPLEX-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15863:SF2","properties":[{"key":"EntryName","value":"MRN COMPLEX-INTERACTING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15749","properties":[{"key":"EntryName","value":"MRNIP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPLRSLEETVSASEEENVGHQQAGNVKQQEKSQPSESRWLKYLEKDSQELELEGTGVCFSKQPSSKMEEPGPRFSQDLPRKRKWSRSTVQPPCSRGVQDSGGSEVAWGPQKGQAGLTWKVKQGSSPCLQENSADCSAGELRGPGKELWSPIQQVTATSSKWAQFVLPPRKSSHVDSEQPRSLQRDPRPAGPAQAKQGTPRAQASREGLSRPTAAVQLPRATHPVTSGSERPCGKTSWDARTPWAEGGPLVLEAQNPRPTRLCDLFITGEDFDDDV","length":343,"molWeight":37743,"crc64":"08C3CE3C1BC827EC","md5":"5E7376B6E87351BCF9D4F3335A71F7D2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":9,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"PTM":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Region":5,"Motif":1,"Compositional bias":3,"Modified residue":2,"Alternative sequence":4,"Natural variant":4,"Mutagenesis":8,"Sequence conflict":1},"uniParcId":"UPI000020CD05"}}