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Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis (PubMed:33139539)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"chloride(in) = chloride(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29823"},{"database":"ChEBI","id":"CHEBI:17996"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"iodide(out) = iodide(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66324"},{"database":"ChEBI","id":"CHEBI:16382"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurine(out) = taurine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66328"},{"database":"ChEBI","id":"CHEBI:507393"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2',3'-cGAMP(out) = 2',3'-cGAMP(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66320"},{"database":"ChEBI","id":"CHEBI:143093"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33171122"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:66321"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33171122"}]},{"directionType":"right-to-left","reactionCrossReference":{"database":"Rhea","id":"RHEA:66322"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33171122"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q66JT1"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24790029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26824658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28193731"}],"value":"Heterohexamer; oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8C, LRRC8D and/or LRRC8B) to form a heterohexamer (PubMed:24790029, PubMed:26824658, PubMed:28193731). 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