{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6IBW4","secondaryAccessions":["B7WPH1","O43788","Q13391","Q96C14","Q96GJ0","Q9BQ71","Q9BUT3","Q9BVD1"],"uniProtkbId":"CNDH2_HUMAN","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":162,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Condensin-2 complex subunit H2"}},"alternativeNames":[{"fullName":{"value":"Chromosome-associated protein H2"},"shortNames":[{"value":"hCAP-H2"}]},{"fullName":{"value":"Kleisin-beta"}},{"fullName":{"value":"Non-SMC condensin II complex subunit H2"}}]},"genes":[{"geneName":{"value":"NCAPH2"},"synonyms":[{"value":"CAPH2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BSP2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532007"}],"value":"Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532007"}],"value":"Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits, NCAPG2, NCAPH2 and NCAPD3 that probably regulate the complex"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6IBW4","intActId":"EBI-2548296"},"interactantTwo":{"uniProtKBAccession":"P42695","geneName":"NCAPD3","intActId":"EBI-722805"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4","intActId":"EBI-2548296"},"interactantTwo":{"uniProtKBAccession":"Q86XI2","geneName":"NCAPG2","intActId":"EBI-1047404"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4","intActId":"EBI-2548296"},"interactantTwo":{"uniProtKBAccession":"Q8WWY3","geneName":"PRPF31","intActId":"EBI-1567797"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4","intActId":"EBI-2548296"},"interactantTwo":{"uniProtKBAccession":"O95347","geneName":"SMC2","intActId":"EBI-355822"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4","intActId":"EBI-2548296"},"interactantTwo":{"uniProtKBAccession":"Q9NTJ3","geneName":"SMC4","intActId":"EBI-356173"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q86W74-2","geneName":"ANKRD46","intActId":"EBI-12109402"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"P05090","geneName":"APOD","intActId":"EBI-715495"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q8WVX3-2","geneName":"ARLN","intActId":"EBI-12003442"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q4LDR2","geneName":"CTXN3","intActId":"EBI-12019274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q9H6Z9","geneName":"EGLN3","intActId":"EBI-1175354"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"P50402","geneName":"EMD","intActId":"EBI-489887"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"P37268","geneName":"FDFT1","intActId":"EBI-714550"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"P24593","geneName":"IGFBP5","intActId":"EBI-720480"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"P21145","geneName":"MAL","intActId":"EBI-3932027"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q5TAL4","geneName":"SNRPC","intActId":"EBI-10246938"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"A0PK00","geneName":"TMEM120B","intActId":"EBI-10171534"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q9P0S9","geneName":"TMEM14C","intActId":"EBI-2339195"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q8N2M4","geneName":"TMEM86A","intActId":"EBI-12015604"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q9Y5Z9","geneName":"UBIAD1","intActId":"EBI-2819725"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"Q8N6Y0","geneName":"USHBP1","intActId":"EBI-739895"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6IBW4-4","intActId":"EBI-10247000"},"interactantTwo":{"uniProtKBAccession":"O95183","geneName":"VAMP5","intActId":"EBI-10191195"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Distributed along the arms of chromosomes assembled in vivo and in vitro"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532007"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532007"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q6IBW4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q6IBW4-2"],"sequenceIds":["VSP_032636"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q6IBW4-5"],"sequenceIds":["VSP_032637","VSP_032638"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q6IBW4-4"],"sequenceIds":["VSP_032639"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CND2 H2 (condensin-2 subunit 2) family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAB03345.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH00473.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH01509.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH01833.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH01937.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH09441.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"CAA16670.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"EAW73552.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"Condensin-2 complex subunit H2","featureId":"PRO_0000326241"},{"type":"Region","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":200,"modifier":"EXACT"},"end":{"value":200,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":228,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8I2"}]},{"type":"Modified residue","location":{"start":{"value":232,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BSP2"}]},{"type":"Modified residue","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":284,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":466,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17525332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":167,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_032636","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":299,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032637","alternativeSequence":{"originalSequence":"SAALPRRYMLRE","alternativeSequences":["VGPTWRPAEPEL"]}},{"type":"Alternative sequence","location":{"start":{"value":300,"modifier":"EXACT"},"end":{"value":605,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032638","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":435,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032639","alternativeSequence":{"originalSequence":"A","alternativeSequences":["AA"]}},{"type":"Sequence conflict","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["D"]}},{"type":"Sequence conflict","location":{"start":{"value":61,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":76,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":215,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":249,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":282,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"in Ref. 5; AAH09441","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":316,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"FD","alternativeSequences":["LN"]}},{"type":"Sequence conflict","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":474,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"in Ref. 1; CAA16670","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0226","category":"Biological process","name":"DNA condensation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"12529303","citationType":"journal article","authors":["Collins J.E.","Goward M.E.","Cole C.G.","Smink L.J.","Huckle E.J.","Knowles S.","Bye J.M.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"12529303"},{"database":"DOI","id":"10.1101/gr.695703"}],"title":"Reevaluating human gene annotation: a second-generation analysis of chromosome 22.","publicationDate":"2003","journal":"Genome Res.","firstPage":"27","lastPage":"36","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15461802","citationType":"journal article","authors":["Collins J.E.","Wright C.L.","Edwards C.A.","Davis M.P.","Grinham J.A.","Cole C.G.","Goward M.E.","Aguado B.","Mallya M.","Mokrab Y.","Huckle E.J.","Beare D.M.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15461802"},{"database":"DOI","id":"10.1186/gb-2004-5-10-r84"}],"title":"A genome annotation-driven approach to cloning the human ORFeome.","publicationDate":"2004","journal":"Genome Biol.","firstPage":"R84.1","lastPage":"R84.11","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"10591208","citationType":"journal article","authors":["Dunham I.","Hunt A.R.","Collins J.E.","Bruskiewich R.","Beare D.M.","Clamp M.","Smink L.J.","Ainscough R.","Almeida J.P.","Babbage A.K.","Bagguley C.","Bailey J.","Barlow K.F.","Bates K.N.","Beasley O.P.","Bird C.P.","Blakey S.E.","Bridgeman A.M.","Buck D.","Burgess J.","Burrill W.D.","Burton J.","Carder C.","Carter N.P.","Chen Y.","Clark G.","Clegg S.M.","Cobley V.E.","Cole C.G.","Collier R.E.","Connor R.","Conroy D.","Corby N.R.","Coville G.J.","Cox A.V.","Davis J.","Dawson E.","Dhami P.D.","Dockree C.","Dodsworth S.J.","Durbin R.M.","Ellington A.G.","Evans K.L.","Fey J.M.","Fleming K.","French L.","Garner A.A.","Gilbert J.G.R.","Goward M.E.","Grafham D.V.","Griffiths M.N.D.","Hall C.","Hall R.E.","Hall-Tamlyn G.","Heathcott R.W.","Ho S.","Holmes S.","Hunt S.E.","Jones M.C.","Kershaw J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.F.","Leversha M.A.","Lloyd C.","Lloyd D.M.","Martyn I.D.","Mashreghi-Mohammadi M.","Matthews L.H.","Mccann O.T.","Mcclay J.","Mclaren S.","McMurray A.A.","Milne S.A.","Mortimore B.J.","Odell C.N.","Pavitt R.","Pearce A.V.","Pearson D.","Phillimore B.J.C.T.","Phillips S.H.","Plumb R.W.","Ramsay H.","Ramsey Y.","Rogers L.","Ross M.T.","Scott C.E.","Sehra H.K.","Skuce C.D.","Smalley S.","Smith M.L.","Soderlund C.","Spragon L.","Steward C.A.","Sulston J.E.","Swann R.M.","Vaudin M.","Wall M.","Wallis J.M.","Whiteley M.N.","Willey D.L.","Williams L.","Williams S.A.","Williamson H.","Wilmer T.E.","Wilming L.","Wright C.L.","Hubbard T.","Bentley D.R.","Beck S.","Rogers J.","Shimizu N.","Minoshima S.","Kawasaki K.","Sasaki T.","Asakawa S.","Kudoh J.","Shintani A.","Shibuya K.","Yoshizaki Y.","Aoki N.","Mitsuyama S.","Roe B.A.","Chen F.","Chu L.","Crabtree J.","Deschamps S.","Do A.","Do T.","Dorman A.","Fang F.","Fu Y.","Hu P.","Hua A.","Kenton S.","Lai H.","Lao H.I.","Lewis J.","Lewis S.","Lin S.-P.","Loh P.","Malaj E.","Nguyen T.","Pan H.","Phan S.","Qi S.","Qian Y.","Ray L.","Ren Q.","Shaull S.","Sloan D.","Song L.","Wang Q.","Wang Y.","Wang Z.","White J.","Willingham D.","Wu H.","Yao Z.","Zhan M.","Zhang G.","Chissoe S.","Murray J.","Miller N.","Minx P.","Fulton R.","Johnson D.","Bemis G.","Bentley D.","Bradshaw H.","Bourne S.","Cordes M.","Du Z.","Fulton L.","Goela D.","Graves T.","Hawkins J.","Hinds K.","Kemp K.","Latreille P.","Layman D.","Ozersky P.","Rohlfing T.","Scheet P.","Walker C.","Wamsley A.","Wohldmann P.","Pepin K.","Nelson J.","Korf I.","Bedell J.A.","Hillier L.W.","Mardis E.","Waterston R.","Wilson R.","Emanuel B.S.","Shaikh T.","Kurahashi H.","Saitta S.","Budarf M.L.","McDermid H.E.","Johnson A.","Wong A.C.C.","Morrow B.E.","Edelmann L.","Kim U.J.","Shizuya H.","Simon M.I.","Dumanski J.P.","Peyrard M.","Kedra D.","Seroussi E.","Fransson I.","Tapia I.","Bruder C.E.","O'Brien K.P.","Wilkinson P.","Bodenteich A.","Hartman K.","Hu X.","Khan A.S.","Lane L.","Tilahun Y.","Wright H."],"citationCrossReferences":[{"database":"PubMed","id":"10591208"},{"database":"DOI","id":"10.1038/990031"}],"title":"The DNA sequence of human chromosome 22.","publicationDate":"1999","journal":"Nature","firstPage":"489","lastPage":"495","volume":"402"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Muscle","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"14532007","citationType":"journal article","authors":["Ono T.","Losada A.","Hirano M.","Myers M.P.","Neuwald A.F.","Hirano T."],"citationCrossReferences":[{"database":"PubMed","id":"14532007"},{"database":"DOI","id":"10.1016/s0092-8674(03)00724-4"}],"title":"Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.","publicationDate":"2003","journal":"Cell","firstPage":"109","lastPage":"121","volume":"115"},"referencePositions":["IDENTIFICATION IN CONDENSIN-2 COMPLEX WITH SMC2; SMC4; NCAPG2; NCAPH2 AND NCAPD3","FUNCTION OF THE COMPLEX","SUBCELLULAR LOCATION"]},{"referenceNumber":7,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"17525332","citationType":"journal article","authors":["Matsuoka S.","Ballif B.A.","Smogorzewska A.","McDonald E.R. III","Hurov K.E.","Luo J.","Bakalarski C.E.","Zhao Z.","Solimini N.","Lerenthal Y.","Shiloh Y.","Gygi S.P.","Elledge S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17525332"},{"database":"DOI","id":"10.1126/science.1140321"}],"title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.","publicationDate":"2007","journal":"Science","firstPage":"1160","lastPage":"1166","volume":"316"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic kidney","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284 AND SER-492","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-492","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":13,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19; SER-95; SER-200; SER-208; SER-284; SER-466 AND SER-492","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":15,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284 AND SER-492","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL021682","properties":[{"key":"ProteinId","value":"CAA16670.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR456604","properties":[{"key":"ProteinId","value":"CAG30490.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"U62317","properties":[{"key":"ProteinId","value":"AAB03345.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471138","properties":[{"key":"ProteinId","value":"EAW73554.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471138","properties":[{"key":"ProteinId","value":"EAW73556.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471138","properties":[{"key":"ProteinId","value":"EAW73552.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC000473","properties":[{"key":"ProteinId","value":"AAH00473.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC001509","properties":[{"key":"ProteinId","value":"AAH01509.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC001833","properties":[{"key":"ProteinId","value":"AAH01833.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC001937","properties":[{"key":"ProteinId","value":"AAH01937.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC009441","properties":[{"key":"ProteinId","value":"AAH09441.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC014939","properties":[{"key":"ProteinId","value":"AAH14939.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS14094.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-1"},{"database":"CCDS","id":"CCDS43038.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-5"},{"database":"CCDS","id":"CCDS54546.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-4"},{"database":"RefSeq","id":"NP_001171940.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001185011.2"}],"isoformId":"Q6IBW4-4"},{"database":"RefSeq","id":"NP_055366.3","properties":[{"key":"NucleotideSequenceId","value":"NM_014551.5"}],"isoformId":"Q6IBW4-5"},{"database":"RefSeq","id":"NP_689512.2","properties":[{"key":"NucleotideSequenceId","value":"NM_152299.4"}],"isoformId":"Q6IBW4-1"},{"database":"PDB","id":"9F5W","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.50 A"},{"key":"Chains","value":"H=1-605"}]},{"database":"PDBsum","id":"9F5W","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-50201","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"118913","properties":[{"key":"Interactions","value":"185"}]},{"database":"ComplexPortal","id":"CPX-985","properties":[{"key":"EntryName","value":"Condensin II complex"}]},{"database":"CORUM","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-43901N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6IBW4","properties":[{"key":"Number of interactors","value":"2630"}]},{"database":"IntAct","id":"Q6IBW4","properties":[{"key":"Interactions","value":"148"}]},{"database":"MINT","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-NCAPH2","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000299821","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q6IBW4","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"NCAPH2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74709496","properties":[{"key":"Description","value":"-"}]},{"database":"CPTAC","id":"CPTAC-5922","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000299821","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"66371","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-1"},{"database":"ProteomicsDB","id":"66372","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-2"},{"database":"ProteomicsDB","id":"66373","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-4"},{"database":"ProteomicsDB","id":"66374","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6IBW4-5"},{"database":"Pumba","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28671","properties":[{"key":"antibodies","value":"137 antibodies from 26 providers"}]},{"database":"CPTC","id":"Q6IBW4","properties":[{"key":"antibodies","value":"1 antibody"}]},{"database":"DNASU","id":"29781","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000299821.15","properties":[{"key":"ProteinId","value":"ENSP00000299821.11"},{"key":"GeneId","value":"ENSG00000025770.20"}],"isoformId":"Q6IBW4-4"},{"database":"Ensembl","id":"ENST00000395698.7","properties":[{"key":"ProteinId","value":"ENSP00000379050.3"},{"key":"GeneId","value":"ENSG00000025770.20"}],"isoformId":"Q6IBW4-5"},{"database":"Ensembl","id":"ENST00000420993.7","properties":[{"key":"ProteinId","value":"ENSP00000410088.2"},{"key":"GeneId","value":"ENSG00000025770.20"}],"isoformId":"Q6IBW4-1"},{"database":"GeneID","id":"29781","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:29781","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000420993.7","properties":[{"key":"ProteinId","value":"ENSP00000410088.2"},{"key":"RefSeqNucleotideId","value":"NM_152299.4"},{"key":"RefSeqProteinId","value":"NP_689512.2"}]},{"database":"UCSC","id":"uc003blq.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q6IBW4-1"},{"database":"AGR","id":"HGNC:25071","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162397314","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"29781","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"29781","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NCAPH2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25071","properties":[{"key":"GeneName","value":"NCAPH2"}]},{"database":"HPA","id":"ENSG00000025770","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"NCAPH2","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"611230","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000025770","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000025770","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2359","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000014443","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_010569_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FDPPEHK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10038475at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6IBW4","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2299718","properties":[{"key":"PathwayName","value":"Condensation of Prophase Chromosomes"}]},{"database":"SignaLink","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000025770","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"29781","properties":[{"key":"hits","value":"609 hits in 1162 CRISPR screens"}]},{"database":"CD-CODE","id":"91857CE7","properties":[{"key":"EntryName","value":"Nucleolus"}]},{"database":"ChiTaRS","id":"NCAPH2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"NCAPH2","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"29781","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6IBW4","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q6IBW4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 22"}]},{"database":"RNAct","id":"Q6IBW4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000025770","properties":[{"key":"ExpressionPatterns","value":"Expressed in cerebellar hemisphere and 188 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6IBW4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532007"}]},{"database":"GO","id":"GO:0000796","properties":[{"key":"GoTerm","value":"C:condensin complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14532007"}]},{"database":"GO","id":"GO:0003682","properties":[{"key":"GoTerm","value":"F:chromatin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0010032","properties":[{"key":"GoTerm","value":"P:meiotic chromosome condensation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007076","properties":[{"key":"GoTerm","value":"P:mitotic chromosome condensation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051306","properties":[{"key":"GoTerm","value":"P:mitotic sister chromatid separation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR031737","properties":[{"key":"EntryName","value":"CNDH2_C"}]},{"database":"InterPro","id":"IPR031719","properties":[{"key":"EntryName","value":"H2_M"}]},{"database":"InterPro","id":"IPR009378","properties":[{"key":"EntryName","value":"H2_N"}]},{"database":"InterPro","id":"IPR031739","properties":[{"key":"EntryName","value":"Ncaph2"}]},{"database":"PANTHER","id":"PTHR14324","properties":[{"key":"EntryName","value":"CONDENSIN-2 COMPLEX SUBUNIT H2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14324:SF3","properties":[{"key":"EntryName","value":"CONDENSIN-2 COMPLEX SUBUNIT H2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16858","properties":[{"key":"EntryName","value":"CNDH2_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16869","properties":[{"key":"EntryName","value":"CNDH2_M"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06278","properties":[{"key":"EntryName","value":"CNDH2_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKVEYLYSLVYQALDFISGKRRAKQLSSVQEDRANGVASSGVPQEAENEFLSLDDFPDSRTNVDLKNDQTPSEVLIIPLLPMALVAPDEMEKNNNPLYSRQGEVLASRKDFRMNTCVPHPRGAFMLEPEGMSPMEPAGVSPMPGTQKDTGRTEEQPMEVSVCRSPVPALGFSQEPGPSPEGPMPLGGGEDEDAEEAVELPEASAPKAALEPKESRSPQQSAALPRRYMLREREGAPEPASCVKETPDPWQSLDPFDSLESKPFKKGRPYSVPPCVEEALGQKRKRKGAAKLQDFHQWYLAAYADHADSRRLRRKGPSFADMEVLYWTHVKEQLETLRKLQRREVAEQWLRPAEEDHLEDSLEDLGAADDFLEPEEYMEPEGADPREAADLDAVPMSLSYEELVRRNVELFIATSQKFVQETELSQRIRDWEDTVQPLLQEQEQHVPFDIHTYGDQLVSRFPQLNEWCPFAELVAGQPAFEVCRSMLASLQLANDYTVEITQQPGLEMAVDTMSLRLLTHQRAHKRFQTYAAPSMAQP","length":605,"molWeight":68227,"crc64":"2C8A1070C27B4547","md5":"F0BD9D8F0D6428FCEA94FD566BB80A4C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":21,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"SIMILARITY":1,"SEQUENCE CAUTION":8},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Modified residue":10,"Alternative sequence":4,"Sequence conflict":13},"uniParcId":"UPI0000207A5C"}}