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Required for efficient export of polyadenylated RNA (PubMed:23222130). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18974867"}],"value":"(Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12951069"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15833825"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15998806"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19059247"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23222130"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33191911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37020021"}],"value":"Tetramer; as part of a THO-DDX39B complex (PubMed:33191911, PubMed:37020021). Component of the THO subcomplex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7 (PubMed:15833825, PubMed:15998806, PubMed:19059247, PubMed:33191911, PubMed:37020021). Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; in the complex interacts with THOC1, THOC2 and THOC5; forms a coiled-coil dimer with THOC5; together with THOC5 and THOC6, plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911, PubMed:37020021). TREX seems to have a dynamic structure involving ATP-dependent remodeling (PubMed:23222130, PubMed:37020021). Interacts with NIF3L1 (PubMed:12951069)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q6I9Y2","intActId":"EBI-716286"},"interactantTwo":{"uniProtKBAccession":"Q8IYE0","geneName":"CCDC146","intActId":"EBI-10749669"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6I9Y2","intActId":"EBI-716286"},"interactantTwo":{"uniProtKBAccession":"Q8NEH6","geneName":"MNS1","intActId":"EBI-743811"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6I9Y2","intActId":"EBI-716286"},"interactantTwo":{"uniProtKBAccession":"O14777","geneName":"NDC80","intActId":"EBI-715849"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6I9Y2","intActId":"EBI-716286"},"interactantTwo":{"uniProtKBAccession":"Q96GM5","geneName":"SMARCD1","intActId":"EBI-358489"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q6I9Y2","intActId":"EBI-716286"},"interactantTwo":{"uniProtKBAccession":"Q13769","geneName":"THOC5","intActId":"EBI-5280316"},"numberOfExperiments":9,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19059247"}],"value":"Interaction with THOC5 is required for nuclear localization"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12951069"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12951069"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19059247"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Nucleus speckle","id":"SL-0186"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the THOC7 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25489052"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"THO complex subunit 7","featureId":"PRO_0000310754"},{"type":"Region","location":{"start":{"value":50,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"Interaction with THOC5","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19059247"}]},{"type":"Region","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Interaction with NIF3L1","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12951069"}]},{"type":"Region","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33191911"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37020021"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7APK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7ZNK"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"7ZNL"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylglycine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25489052"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Modified residue","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":5,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":36,"modifier":"EXACT"},"end":{"value":36,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19608861"}]},{"type":"Sequence conflict","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in Ref. 1; 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