{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6BIF0","secondaryAccessions":["B5RUQ3"],"uniProtkbId":"BUD3_DEBHA","entryAudit":{"firstPublicDate":"2007-07-24","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2008-12-16","entryVersion":79,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)","commonName":"Yeast","synonyms":["Torulaspora hansenii"],"taxonId":284592,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Pichiomycetes","Debaryomycetaceae","Debaryomyces"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"Bud site selection protein 3"}}},"genes":[{"geneName":{"value":"BUD3"},"orderedLocusNames":[{"value":"DEHA2G11000g"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Co-assembles with BUD4 at bud sites. BUD4 and BUD3 may cooperate to recognize a spatial landmark (the neck filaments) during mitosis and they subsequently become a landmark for establishing the axial budding pattern in G1 (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BUD3 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1345,"modifier":"EXACT"}},"description":"Bud site selection protein 3","featureId":"PRO_0000295639"},{"type":"Region","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":951,"modifier":"EXACT"},"end":{"value":998,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":854,"modifier":"EXACT"},"end":{"value":867,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":874,"modifier":"EXACT"},"end":{"value":892,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":893,"modifier":"EXACT"},"end":{"value":903,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":910,"modifier":"EXACT"},"end":{"value":935,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":961,"modifier":"EXACT"},"end":{"value":980,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0131","category":"Biological process","name":"Cell cycle"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15229592","citationType":"journal article","authors":["Dujon B.","Sherman D.","Fischer G.","Durrens P.","Casaregola S.","Lafontaine I.","de Montigny J.","Marck C.","Neuveglise C.","Talla E.","Goffard N.","Frangeul L.","Aigle M.","Anthouard V.","Babour A.","Barbe V.","Barnay S.","Blanchin S.","Beckerich J.-M.","Beyne E.","Bleykasten C.","Boisrame A.","Boyer J.","Cattolico L.","Confanioleri F.","de Daruvar A.","Despons L.","Fabre E.","Fairhead C.","Ferry-Dumazet H.","Groppi A.","Hantraye F.","Hennequin C.","Jauniaux N.","Joyet P.","Kachouri R.","Kerrest A.","Koszul R.","Lemaire M.","Lesur I.","Ma L.","Muller H.","Nicaud J.-M.","Nikolski M.","Oztas S.","Ozier-Kalogeropoulos O.","Pellenz S.","Potier S.","Richard G.-F.","Straub M.-L.","Suleau A.","Swennen D.","Tekaia F.","Wesolowski-Louvel M.","Westhof E.","Wirth B.","Zeniou-Meyer M.","Zivanovic Y.","Bolotin-Fukuhara M.","Thierry A.","Bouchier C.","Caudron B.","Scarpelli C.","Gaillardin C.","Weissenbach J.","Wincker P.","Souciet J.-L."],"citationCrossReferences":[{"database":"PubMed","id":"15229592"},{"database":"DOI","id":"10.1038/nature02579"}],"title":"Genome evolution in yeasts.","publicationDate":"2004","journal":"Nature","firstPage":"35","lastPage":"44","volume":"430"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CR382139","properties":[{"key":"ProteinId","value":"CAR65947.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_002770613.1","properties":[{"key":"NucleotideSequenceId","value":"XM_002770567.1"}]},{"database":"AlphaFoldDB","id":"Q6BIF0","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6BIF0","properties":[{"key":"Number of interactors","value":"160"}]},{"database":"STRING","id":"284592.Q6BIF0","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"8999172","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dha:DEHA2G11000g","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:DEHA2G11000g","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QSNK","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_004185_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6BIF0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LATNWPA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"4066896at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000599","properties":[{"key":"Component","value":"Chromosome G"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"InterPro","id":"IPR057454","properties":[{"key":"EntryName","value":"Bud3_C"}]},{"database":"InterPro","id":"IPR021895","properties":[{"key":"EntryName","value":"Bud3_N"}]},{"database":"InterPro","id":"IPR000219","properties":[{"key":"EntryName","value":"DH_dom"}]},{"database":"Pfam","id":"PF12015","properties":[{"key":"EntryName","value":"Bud3_N"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25351","properties":[{"key":"EntryName","value":"PH_BUD3_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00325","properties":[{"key":"EntryName","value":"RhoGEF"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSVYHRYASGEYDKTYFEKASESRKHDDKVGRIQISPLLGQFSTSDTLYKFKEKSIEEWLAIFPKAAYFKGYDESLFGNVIIMVYENSHTGKLNTTSFSKFGVTSYDNLVLDARSRFWPSCENLLPSYQKSNVRRSLAITNLKNYNKLVNSPGNFYVNKSWDETYAGSLANNMQLISEKKPEKFGLKLLELGLLQTHCIQSTVLDVIYDNASSETSDKIVEENNKLVFLIGSQLEQLFDPLLEYSPEIMEFSYTVPVDAISPQIKNNELINTIISELLTVQTNFTMRLVNLLQNFIIPLRIHVLAATSSSGITKINQVFPPTIDEITRINCILHDSLKKASAFGYVEIMKAVGTIMPYFYKAFIRHEANLKNFRDNLAKFHSKNNKKIFENTMINKGNLGIRDIDSIVAGSLLELPKLKLILVRLKDSIIFEKTKLSNFEDDPSNEFFTIEKYFNSAVDVIDAFGFEEENNQTKIDIRQRVFTPTGKILTELASNWPPELQYGWLARKVVGIYEMRNIKPLNDTFYDLDILIIFSDHILFLTIVDDSYYNERNNESMKNLCVSDILMHSLVNDKPLPNLKSLPTMEVNCWCIINEVITTTYKGVSPITSKTQEFLKFVNISKTGFKNNNAENSTISKNYEILDGSDRGNVDGCKIIELINKSTVLNKRKPFHLFRSNDPKLHIYSIAQELSAYQEESCKSPMALYLNLSIHDPKKYFEENQTVHFVLNASFINDHQIHMVGFNRAETFELNEIISSNDLQVCLKEVIVKNFSLLFNTFSNISKMLTQGYAYDINYCANIFTQIDEIKLNEHRQEIAKNKSTDSISRPKTRNVSEIISIPEVYMNKISPSNTNTRDQRSQQRRTEKRLSTRSKNNSRDVEVKKSSQERPDKRNSMIKKVFRSLRRSFDGIENSTPKTEIHENNNTSKLQDSSSFSGKKNEYTSLYKPVPQLQTKEQKHVHEQVQVQEQGQGQGQGQEQEQGQEQEKEQEQSFSEANIPRDIDNYTGIQMRKECNNSVQQSRNTSGSLDVNSHFEFPPHLDSSFGSNNNTIILVNDNENRHKNRPAPEKISILDSTDDHSSNIPRRSENVGYGKFNVEDFYDDGEANWVSISNENYSLLNAEIRALKEEAHMDTEDIIELNDSDNITEDEMRDVYESKDFDAFYTPQNQSVAQFGDNPTSLKNENREMSTQSLASSEIIEVFGKQIDSNFRSDYIPNLNENLHSINSNKKFGFQNDHRFSVLTSSDDEFFSSDDFASSLPIERQENKKSHSPMIMNSSSSDATIINENFEEKLLPATPIDCDDKVLPSSQIHKNMQSSSIRSDSFSTTYESMTYLSEILNGHLNFSD","length":1345,"molWeight":154212,"crc64":"747537FC3340EEB5","md5":"97CED22B42192F2AE2576100C4F6E347"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":5},"uniParcId":"UPI00017F890C"}}