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The HUSH complex represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (By similarity). The HUSH complex also represses exogenous retroviruses and synthetic transgenes (By similarity). Mediates silencing of unintegrated retroviral DNA following recruitment by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). Within the HUSH complex, TASOR acts as the central scaffold which recruits MPHOSPH8 and PPHLN1 to mobile genetic elements and mediates association with SETDB1 and MORC2 (By similarity). The ability to silence mobile genetic elements plays a crucial role in early embryonic development: it is required to maintain epiblast cell fitness and cell division (PubMed:24781204, PubMed:28839193)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK61"}],"value":"Core component of the HUSH complex, also named HUSH1 complex, composed of TASOR, PPHLN1 and MPHOSPH8 (By similarity). Interacts with MORC2; recruiting MORC2 to heterochromatic loci (By similarity). Interacts with ZNF638; leading to recruitment of the HUSH complex to unintegrated retroviral DNA (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK61"}],"value":"Localizes to chromatin"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24781204"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK61"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q69ZR9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q69ZR9-2"],"sequenceIds":["VSP_042114","VSP_042115","VSP_042116","VSP_042117"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24781204"}],"value":"Present in skin, brain and testis (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28839193"}],"value":"Expressed in the epiblast at 5.5 dpc, expression extends into the extraembryonic ectoderm at 6.5 dpc, and at 7.5 dpc expressed in embryonic ectoderm, allantois, amnion and chorion. From 8.5 to 9.5 dpc, ubiquitously expressed in the developing embryo"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UK61"}],"value":"The TASOR pseudo-PARP domain is essential for the repression of mobile genetic elements"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24781204"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28839193"}],"value":"Embryonic lethality with robust developmentally delayed phenotype observed at 8.5 dpc, progressing through 9.5 dpc with full lethality by 12.5 dpc (PubMed:24781204, PubMed:28839193). RNAi-mediated knockdown in zygotes results in formation of multipolar spindles and increased ratio of arrested or incorrectly developed embryos (PubMed:28839193)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TASOR family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"31112734"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34272044"}],"value":"Was previously reported to coordinate an interaction network required for early embryonic development and cell division. 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