{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q69ZN6","secondaryAccessions":["Q3U3K6","Q3US34"],"uniProtkbId":"GNPTA_MOUSE","entryAudit":{"firstPublicDate":"2006-03-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-03-07","entryVersion":144,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"N-acetylglucosamine-1-phosphotransferase subunits alpha/beta"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"2.7.8.17"}]},"alternativeNames":[{"fullName":{"value":"GlcNAc-1-phosphotransferase subunits alpha/beta"}},{"fullName":{"value":"Stealth protein GNPTAB"}},{"fullName":{"value":"UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta"}}],"contains":[{"recommendedName":{"fullName":{"value":"N-acetylglucosamine-1-phosphotransferase subunit alpha"}}},{"recommendedName":{"fullName":{"value":"N-acetylglucosamine-1-phosphotransferase subunit beta"}}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Gnptab"},"synonyms":[{"value":"Gnpta"},{"value":"Kiaa1208"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:13581"},{"database":"Rhea","id":"RHEA-COMP:14507"},{"database":"Rhea","id":"RHEA-COMP:14508"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57705"},{"database":"ChEBI","id":"CHEBI:57865"},{"database":"ChEBI","id":"CHEBI:140357"},{"database":"ChEBI","id":"CHEBI:140369"}],"ecNumber":"2.7.8.17","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"Hexamer of two alpha, two beta and two gamma (GNPTG) subunits; disulfide-linked. The alpha and/or the beta subunits of the enzyme constitute the catalytic subunits. Interacts with LYSET; facilitates proper localization of GNPTAB"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","molecule":"N-acetylglucosamine-1-phosphotransferase subunit alpha","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"N-acetylglucosamine-1-phosphotransferase subunit beta","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q69ZN6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q69ZN6-2"],"sequenceIds":["VSP_017340","VSP_017341"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"The DMAP1-binding domain mediates substrate recognition. It specifically recognizes a conformation-dependent protein determinant present in acid hydrolases"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3T906"}],"value":"The alpha- and beta-subunits are generated by a proteolytic cleavage by MBTPS1 protease at the Lys-907-Asp-908 bond"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17962477"}],"value":"Severe retinal degeneration, growth retardation and secretory cell lesions. Mice are smaller with a reduced mean body weight and length, along with a reduction in total tissue mass and lean body mass. They show elevated levels of serum lysosomal enzymes, cartilage defects, and display cytoplasmic alterations in secretory cells of several exocrine glands"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"value":"Stealth proteins are part of a protein family that is conserved from bacteria to higher eukaryotes. Family members were first identified in microbes as proteins that help pathogens to elude the host innate immune system. Microbial stealth proteins are most likely involved in the biosynthesis of exopolysaccharides. Stealth proteins are predicted to function as hexose-1-phosphoryltransferases"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the stealth family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAD32410.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAE32779.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":907,"modifier":"EXACT"}},"description":"N-acetylglucosamine-1-phosphotransferase subunit alpha","featureId":"PRO_0000225010"},{"type":"Chain","location":{"start":{"value":908,"modifier":"EXACT"},"end":{"value":1235,"modifier":"EXACT"}},"description":"N-acetylglucosamine-1-phosphotransferase subunit beta","featureId":"PRO_0000225011"},{"type":"Transmembrane","location":{"start":{"value":22,"modifier":"EXACT"},"end":{"value":42,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":1194,"modifier":"EXACT"},"end":{"value":1214,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"LNR 1"},{"type":"Repeat","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"LNR 2"},{"type":"Domain","location":{"start":{"value":699,"modifier":"EXACT"},"end":{"value":823,"modifier":"EXACT"}},"description":"DMAP1-binding","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01260"}]},{"type":"Domain","location":{"start":{"value":984,"modifier":"EXACT"},"end":{"value":1019,"modifier":"EXACT"}},"description":"EF-hand","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}]},{"type":"Region","location":{"start":{"value":751,"modifier":"EXACT"},"end":{"value":783,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":830,"modifier":"EXACT"},"end":{"value":850,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":848,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":449,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":464,"modifier":"EXACT"},"end":{"value":464,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":467,"modifier":"EXACT"},"end":{"value":467,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":516,"modifier":"EXACT"},"end":{"value":516,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":531,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":997,"modifier":"EXACT"},"end":{"value":997,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":999,"modifier":"EXACT"},"end":{"value":999,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":1001,"modifier":"EXACT"},"end":{"value":1001,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":1008,"modifier":"EXACT"},"end":{"value":1008,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00448"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Site","location":{"start":{"value":907,"modifier":"EXACT"},"end":{"value":908,"modifier":"EXACT"}},"description":"Cleavage; by MBTPS1","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Glycosylation","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":83,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":114,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":614,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":729,"modifier":"EXACT"},"end":{"value":729,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":988,"modifier":"EXACT"},"end":{"value":988,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1108,"modifier":"EXACT"},"end":{"value":1108,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":461,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}]},{"type":"Disulfide bond","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":468,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}]},{"type":"Disulfide bond","location":{"start":{"value":505,"modifier":"EXACT"},"end":{"value":528,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}]},{"type":"Disulfide bond","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":535,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00525"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_017340","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_017341","alternativeSequence":{"originalSequence":"DQYHVLFDSYRDNIAGKSFQN","alternativeSequences":["MGSTSASWASLSPSSRLSSSE"]}},{"type":"Sequence conflict","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"in Ref. 2; BAE24503","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":707,"modifier":"EXACT"},"end":{"value":707,"modifier":"EXACT"}},"description":"in Ref. 2; BAE32779","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15368895","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Koseki H.","Hiraoka S.","Saga Y.","Seino S.","Nishimura M.","Kaisho T.","Hoshino K.","Kitamura H.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"15368895"},{"database":"DOI","id":"10.1093/dnares/11.3.205"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2004","journal":"DNA Res.","firstPage":"205","lastPage":"218","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Head","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16299590","citationType":"journal article","authors":["Sperisen P.","Schmid C.D.","Bucher P.","Zilian O."],"citationCrossReferences":[{"database":"PubMed","id":"16299590"},{"database":"DOI","id":"10.1371/journal.pcbi.0010063"}],"title":"Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.","publicationDate":"2005","journal":"PLoS Comput. Biol.","firstPage":"492","lastPage":"499","volume":"1"},"referencePositions":["IDENTIFICATION AS A STEALTH PROTEIN","PREDICTION OF FUNCTION"]},{"referenceNumber":4,"citation":{"id":"17962477","citationType":"journal article","authors":["Gelfman C.M.","Vogel P.","Issa T.M.","Turner C.A.","Lee W.S.","Kornfeld S.","Rice D.S."],"citationCrossReferences":[{"database":"PubMed","id":"17962477"},{"database":"DOI","id":"10.1167/iovs.07-0452"}],"title":"Mice lacking alpha/beta subunits of GlcNAc-1-phosphotransferase exhibit growth retardation, retinal degeneration, and secretory cell lesions.","publicationDate":"2007","journal":"Invest. Ophthalmol. Vis. Sci.","firstPage":"5221","lastPage":"5228","volume":"48"},"referencePositions":["DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK173132","properties":[{"key":"ProteinId","value":"BAD32410.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK140867","properties":[{"key":"ProteinId","value":"BAE24503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK154710","properties":[{"key":"ProteinId","value":"BAE32779.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS24110.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q69ZN6-1"},{"database":"RefSeq","id":"NP_001004164.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001004164.3"}],"isoformId":"Q69ZN6-1"},{"database":"RefSeq","id":"NP_001351636.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001364707.2"}],"isoformId":"Q69ZN6-2"},{"database":"AlphaFoldDB","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"240639","properties":[{"key":"Interactions","value":"3"}]},{"database":"FunCoup","id":"Q69ZN6","properties":[{"key":"Number of interactors","value":"1982"}]},{"database":"STRING","id":"10090.ENSMUSP00000020251","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q69ZN6","properties":[{"key":"glycosylation","value":"8 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q69ZN6","properties":[{"key":"glycosylation","value":"17 sites, 9 N-linked glycans (13 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000020251","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"271415","properties":[{"key":"Description","value":"-"}],"isoformId":"Q69ZN6-1"},{"database":"ProteomicsDB","id":"271416","properties":[{"key":"Description","value":"-"}],"isoformId":"Q69ZN6-2"},{"database":"Pumba","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"44958","properties":[{"key":"antibodies","value":"72 antibodies from 15 providers"}]},{"database":"Ensembl","id":"ENSMUST00000020251.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000020251.8"},{"key":"GeneId","value":"ENSMUSG00000035311.17"}],"isoformId":"Q69ZN6-1"},{"database":"GeneID","id":"432486","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:432486","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007grk.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q69ZN6-1"},{"database":"UCSC","id":"uc011xlg.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q69ZN6-2"},{"database":"AGR","id":"MGI:3643902","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79158","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:3643902","properties":[{"key":"GeneName","value":"Gnptab"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000035311","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QQMR","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000006747","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_002469_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MIDRVVM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"263283at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.8.17","properties":[{"key":"OrganismId","value":"3474"}]},{"database":"BioGRID-ORCS","id":"432486","properties":[{"key":"hits","value":"2 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:Q69ZN6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"Q69ZN6","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000035311","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventral tegmental area and 247 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q69ZN6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070622","properties":[{"key":"GoTerm","value":"C:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0003976","properties":[{"key":"GoTerm","value":"F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046835","properties":[{"key":"GoTerm","value":"P:carbohydrate phosphorylation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17652091"}]},{"database":"GO","id":"GO:0007040","properties":[{"key":"GoTerm","value":"P:lysosome organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0016256","properties":[{"key":"GoTerm","value":"P:N-glycan processing to lysosome"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0009306","properties":[{"key":"GoTerm","value":"P:protein secretion"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17652091"}]},{"database":"GO","id":"GO:0033299","properties":[{"key":"GoTerm","value":"P:secretion of lysosomal enzymes"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19710420"}]},{"database":"CDD","id":"cd21599","properties":[{"key":"EntryName","value":"RRM1_GNPTAB"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd21600","properties":[{"key":"EntryName","value":"RRM2_GNPTAB"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.300.320:FF:000002","properties":[{"key":"EntryName","value":"N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.300.320","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010506","properties":[{"key":"EntryName","value":"DMAP1-bd"}]},{"database":"InterPro","id":"IPR018247","properties":[{"key":"EntryName","value":"EF_Hand_1_Ca_BS"}]},{"database":"InterPro","id":"IPR002048","properties":[{"key":"EntryName","value":"EF_hand_dom"}]},{"database":"InterPro","id":"IPR041536","properties":[{"key":"EntryName","value":"GNPTAB_reg"}]},{"database":"InterPro","id":"IPR060126","properties":[{"key":"EntryName","value":"Ig_GNPTAB"}]},{"database":"InterPro","id":"IPR035993","properties":[{"key":"EntryName","value":"Notch-like_dom_sf"}]},{"database":"InterPro","id":"IPR000800","properties":[{"key":"EntryName","value":"Notch_dom"}]},{"database":"InterPro","id":"IPR047141","properties":[{"key":"EntryName","value":"Stealth"}]},{"database":"InterPro","id":"IPR031358","properties":[{"key":"EntryName","value":"Stealth_CR1"}]},{"database":"InterPro","id":"IPR021520","properties":[{"key":"EntryName","value":"Stealth_CR2"}]},{"database":"InterPro","id":"IPR031357","properties":[{"key":"EntryName","value":"Stealth_CR3"}]},{"database":"InterPro","id":"IPR031356","properties":[{"key":"EntryName","value":"Stealth_CR4"}]},{"database":"PANTHER","id":"PTHR24045","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR24045:SF0","properties":[{"key":"EntryName","value":"N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06464","properties":[{"key":"EntryName","value":"DMAP_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18440","properties":[{"key":"EntryName","value":"GlcNAc-1_reg"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF26737","properties":[{"key":"EntryName","value":"Ig_GNPTAB"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00066","properties":[{"key":"EntryName","value":"Notch"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF17101","properties":[{"key":"EntryName","value":"Stealth_CR1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11380","properties":[{"key":"EntryName","value":"Stealth_CR2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17102","properties":[{"key":"EntryName","value":"Stealth_CR3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17103","properties":[{"key":"EntryName","value":"Stealth_CR4"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01137","properties":[{"key":"EntryName","value":"DMAP_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00004","properties":[{"key":"EntryName","value":"NL"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF90193","properties":[{"key":"EntryName","value":"Notch domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51912","properties":[{"key":"EntryName","value":"DMAP1_BIND"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00018","properties":[{"key":"EntryName","value":"EF_HAND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50222","properties":[{"key":"EntryName","value":"EF_HAND_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50258","properties":[{"key":"EntryName","value":"LNR"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MLLKLLQRQTYTCLSHRYGLYVCFVGVVVTIVSAFQFGEVVLEWSRDQYHVLFDSYRDNIAGKSFQNRLCLPMPIDVVYTWVNGTDLELLKELQQVREHMEEEQRAMRETLGKNTTEPTKKSEKQLECLLTHCIKVPMLVLDPPLPANCTLKDLPTLYPSFHAASDMFNVAKPKNPSTNVSVVVFDTTKDVEDAHAGPFKGGSKQMVWRAYLTTDKEAPGLVLMQGLAFLSGFPPTFKETSQLKTKLPEKLSSKIKLLRLYSEASVALLKLNNPKGFQELNKQTKKNMTIDGKELTISPAYLLWDLSAISQSKQDEDVSASRFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDIFQNLSHLPTFSSPAIESHIHRIEGLSQKFIYLNDDVMFGKDVWPDDFYSHSKGQKVYLTWPVPNCAEGCPGSWIKDGYCDKACNNSACDWDGGDCSGNTAGNRFVAGGGGTGNIGAGQHWQFGGGINTISYCNQGCANSWLADKFCDQACNVLSCGFDAGDCGQDHFHELYKVTLLPNQTHYVVPKGEYLSYFSFANIARRGVEGTYSDNPIIRHASIANKWKTIHLIMHSGMNATTIYFNLTLQNANDEEFKIQIAVEVDTREAPKLNSTTQKAYESLVSPVTPLPQADVPFEDVPKEKRFPKIRRHDVNATGRFQEEVKIPRVNISLLPKEAQVRLSNLDLQLERGDITLKGYNLSKSALLRSFLGNSLDTKIKPQARTDETKGNLEVPQENPSHRRPHGFAGEHRSERWTAPAETVTVKGRDHALNPPPVLETNARLAQPTLGVTVSKENLSPLIVPPESHLPKEEESDRAEGNAVPVKELVPGRRLQQNYPGFLPWEKKKYFQDLLDEEESLKTQLAYFTDSKHTGRQLKDTFADSLRYVNKILNSKFGFTSRKVPAHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMSAVQPLNISQVFHEVDTDQSGVLSDREIRTLATRIHDLPLSLQDLTGLEHMLINCSKMLPANITQLNNIPPTQEAYYDPNLPPVTKSLVTNCKPVTDKIHKAYKDKNKYRFEIMGEEEIAFKMIRTNVSHVVGQLDDIRKNPRKFVCLNDNIDHNHKDARTVKAVLRDFYESMFPIPSQFELPREYRNRFLHMHELQEWRAYRDKLKFWTHCVLATLIIFTIFSFFAEQIIALKRKIFPRRRIHKEASPDRIRV","length":1235,"molWeight":140984,"crc64":"683038D0FDB673FF","md5":"0CCFA412A5D0BDFD820D262EEBA07590"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":2,"DOMAIN":1,"PTM":1,"DISRUPTION PHENOTYPE":1,"MISCELLANEOUS":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":2,"Transmembrane":2,"Repeat":2,"Domain":2,"Region":2,"Compositional bias":1,"Binding site":10,"Site":1,"Glycosylation":8,"Disulfide bond":4,"Alternative sequence":2,"Sequence conflict":2},"uniParcId":"UPI0000471703"}}