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The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01397"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16227571"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16543150"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19650074"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21217699"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22547026"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30224647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33837287"}],"value":"Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:30224647, PubMed:33837287). Forms a MSL heterotetrameric core with MSL2 (PubMed:16227571). Interacts (via PEHE domain) with KAT8 (via HAT domain) and MSL3 (via MRG domain); both interactions are direct (PubMed:21217699, PubMed:22547026, PubMed:30224647). Directly interacts with NUPR1 (PubMed:19650074). Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (PubMed:19650074). Interacts with TTC4, ECM2 and PIHD1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q68DK7","intActId":"EBI-2560816"},"interactantTwo":{"uniProtKBAccession":"Q9HCI7","geneName":"MSL2","intActId":"EBI-2560775"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q68DK7-1","intActId":"EBI-26435399"},"interactantTwo":{"uniProtKBAccession":"Q9H7Z6-1","geneName":"KAT8","intActId":"EBI-26435386"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15561718"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PDM1"}],"value":"Nucleus, 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