{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q64092","secondaryAccessions":["A2AEW3","A2AEW4","Q3U8H0","Q3UMV4","Q3UT52","Q7TNC1","Q8BN29"],"uniProtkbId":"TFE3_MOUSE","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-09","entryVersion":169,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1732746"}],"value":"Transcription factor E3"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1732746"}],"value":"mTFE3"}]}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"1732746"},{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:98511"}],"value":"Tfe3"},"synonyms":[{"value":"Tcfe3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16936731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20713358"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23582324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29146937"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30595499"}],"value":"Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:16936731, PubMed:29146937). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (PubMed:16936731). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation (PubMed:27913603). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity (PubMed:27913603). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (PubMed:23582324). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (By similarity). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation (PubMed:30595499). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (PubMed:27913603). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (PubMed:16936731). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similarity). It also binds very well to a USF/MLTF site (By similarity). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TSC22D1 at E-boxes in the gene proximal promoter (PubMed:20713358). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20713358"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30595499"}],"value":"Homodimer and heterodimer; with TFEB or MITF (By similarity). Interacts with RRAGC/RagC GDP-bound and RRAGD/RagD GDP-bound; promoting its recruitment to lysosomal membrane in the presence of nutrients (PubMed:30595499). Interacts with TSC22D1; the interaction is enhanced in the presence of TGF-beta (PubMed:20713358)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23582324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"}],"value":"When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD): it is then phosphorylated by MTOR (By similarity). Phosphorylation by MTOR prevents nuclear translocation and promotes ubiquitination and degradation (PubMed:23582324, PubMed:27913603). Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:23582324, PubMed:27913603)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23582324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"21209915"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21209915"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23582324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}],"value":"Lysosome membrane","id":"SL-0157"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q64092-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q64092-2"],"sequenceIds":["VSP_022143"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q64092-3"],"sequenceIds":["VSP_022143","VSP_022144"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q64092-4"],"sequenceIds":["VSP_022144"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16936731"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20713358"}],"value":"Induced by TGF-beta"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}],"value":"Sumoylated; does not affect dimerization with MITF"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"}],"value":"Phosphorylation ar Ser-47 and Ser-320 by MTOR via non-canonical mTORC1 pathway regulates its stability and subcellular location, respectively (PubMed:27913603). When nutrients are present, phosphorylation by MTOR at Ser-47 promotes ubiquitination by the SCF(BTRC) complex, followed by degradation (By similarity). When nutrients are present, phosphorylation by MTOR at Ser-320 also promotes association with 14-3-3/YWHA adapters and retention in the cytosol (PubMed:27913603). Phosphorylation at Ser-47 plays a more critical role than phosphorylation at Ser-320 for TFE3 inactivation (By similarity). Inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and transcription factor activity (PubMed:27913603)"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}],"value":"Ubiquitinated by the SCF(BTRC) and SCF(FBXW11) complexes following phosphorylation at Ser-47 by MTOR, leading to its degradation by the proteasome"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MiT/TFE family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Transcription factor E3","featureId":"PRO_0000127472"},{"type":"Domain","location":{"start":{"value":345,"modifier":"EXACT"},"end":{"value":398,"modifier":"EXACT"}},"description":"bHLH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"Region","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":270,"modifier":"EXACT"}},"description":"Strong transcription activation domain","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":408,"modifier":"EXACT"},"end":{"value":429,"modifier":"EXACT"}},"description":"Leucine-zipper"},{"type":"Region","location":{"start":{"value":439,"modifier":"EXACT"},"end":{"value":495,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":530,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":355,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}]},{"type":"Compositional bias","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":446,"modifier":"EXACT"},"end":{"value":457,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"Phosphoserine; by MTOR","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}]},{"type":"Modified residue","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Phosphoserine; by MTOR","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"}]},{"type":"Modified residue","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}]},{"type":"Modified residue","location":{"start":{"value":545,"modifier":"EXACT"},"end":{"value":545,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":551,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":553,"modifier":"EXACT"},"end":{"value":553,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":557,"modifier":"EXACT"},"end":{"value":557,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":565,"modifier":"EXACT"},"end":{"value":565,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}]},{"type":"Cross-link","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19532"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_022143","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":260,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"in isoform 3 and isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_022144","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":320,"modifier":"EXACT"},"end":{"value":320,"modifier":"EXACT"}},"description":"Impaired phosphorylation by MTOR, leading to constitutive nuclear localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27913603"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":73,"modifier":"EXACT"},"end":{"value":73,"modifier":"EXACT"}},"description":"in Ref. 1; BAE24128/BAE25994","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"in Ref. 4; AAB21130","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"QERRE","alternativeSequences":["TSGTR"]}},{"type":"Sequence conflict","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in Ref. 1; BAE25994","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":558,"modifier":"EXACT"},"end":{"value":558,"modifier":"EXACT"}},"description":"in Ref. 4; AAB21130","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"in Ref. 4; AAB21130","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}}],"keywords":[{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0458","category":"Cellular component","name":"Lysosome"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"},{"value":"Egg","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"1732746","citationType":"journal article","authors":["Roman C.","Matera A.G.","Cooper C.","Artandi S.","Blain S.","Ward D.C.","Calame K."],"citationCrossReferences":[{"database":"PubMed","id":"1732746"},{"database":"DOI","id":"10.1128/mcb.12.2.817-827.1992"}],"title":"mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization.","publicationDate":"1992","journal":"Mol. Cell. Biol.","firstPage":"817","lastPage":"827","volume":"12"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 127-572"]},{"referenceNumber":5,"citation":{"id":"16936731","citationType":"journal article","authors":["Huan C.","Kelly M.L.","Steele R.","Shapira I.","Gottesman S.R.S.","Roman C.A.J."],"citationCrossReferences":[{"database":"PubMed","id":"16936731"},{"database":"DOI","id":"10.1038/ni1378"}],"title":"Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.","publicationDate":"2006","journal":"Nat. Immunol.","firstPage":"1082","lastPage":"1091","volume":"7"},"referencePositions":["FUNCTION","DNA-BINDING","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-545; SER-551; SER-553 AND SER-557","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"20713358","citationType":"journal article","authors":["Kato M.","Wang L.","Putta S.","Wang M.","Yuan H.","Sun G.","Lanting L.","Todorov I.","Rossi J.J.","Natarajan R."],"citationCrossReferences":[{"database":"PubMed","id":"20713358"},{"database":"DOI","id":"10.1074/jbc.m110.165027"}],"title":"Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"34004","lastPage":"34015","volume":"285"},"referencePositions":["FUNCTION","INTERACTION WITH TSC22D1","INDUCTION BY TGF-BETA"]},{"referenceNumber":8,"citation":{"id":"21209915","citationType":"journal article","authors":["Hong S.B.","Oh H.","Valera V.A.","Baba M.","Schmidt L.S.","Linehan W.M."],"citationCrossReferences":[{"database":"PubMed","id":"21209915"},{"database":"DOI","id":"10.1371/journal.pone.0015793"}],"title":"Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"E15793","lastPage":"E15793","volume":"5"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":9,"citation":{"id":"23582324","citationType":"journal article","authors":["Betschinger J.","Nichols J.","Dietmann S.","Corrin P.D.","Paddison P.J.","Smith A."],"citationCrossReferences":[{"database":"PubMed","id":"23582324"},{"database":"DOI","id":"10.1016/j.cell.2013.03.012"}],"title":"Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3.","publicationDate":"2013","journal":"Cell","firstPage":"335","lastPage":"347","volume":"153"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":10,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-187","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"27913603","citationType":"journal article","authors":["Wada S.","Neinast M.","Jang C.","Ibrahim Y.H.","Lee G.","Babu A.","Li J.","Hoshino A.","Rowe G.C.","Rhee J.","Martina J.A.","Puertollano R.","Blenis J.","Morley M.","Baur J.A.","Seale P.","Arany Z."],"citationCrossReferences":[{"database":"PubMed","id":"27913603"},{"database":"DOI","id":"10.1101/gad.287953.116"}],"title":"The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.","publicationDate":"2016","journal":"Genes Dev.","firstPage":"2551","lastPage":"2564","volume":"30"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","PHOSPHORYLATION AT SER-320","MUTAGENESIS OF SER-320"]},{"referenceNumber":12,"citation":{"id":"29146937","citationType":"journal article","authors":["Willett R.","Martina J.A.","Zewe J.P.","Wills R.","Hammond G.R.V.","Puertollano R."],"citationCrossReferences":[{"database":"PubMed","id":"29146937"},{"database":"DOI","id":"10.1038/s41467-017-01871-z"}],"title":"TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.","publicationDate":"2017","journal":"Nat. Commun.","firstPage":"1580","lastPage":"1580","volume":"8"},"referencePositions":["FUNCTION"]},{"referenceNumber":13,"citation":{"id":"30595499","citationType":"journal article","authors":["Villegas F.","Lehalle D.","Mayer D.","Rittirsch M.","Stadler M.B.","Zinner M.","Olivieri D.","Vabres P.","Duplomb-Jego L.","De Bont E.S.J.M.","Duffourd Y.","Duijkers F.","Avila M.","Genevieve D.","Houcinat N.","Jouan T.","Kuentz P.","Lichtenbelt K.D.","Thauvin-Robinet C.","St-Onge J.","Thevenon J.","van Gassen K.L.I.","van Haelst M.","van Koningsbruggen S.","Hess D.","Smallwood S.A.","Riviere J.B.","Faivre L.","Betschinger J."],"citationCrossReferences":[{"database":"PubMed","id":"30595499"},{"database":"DOI","id":"10.1016/j.stem.2018.11.021"}],"title":"Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3.","publicationDate":"2019","journal":"Cell Stem Cell","firstPage":"257","lastPage":"270","volume":"24"},"referencePositions":["FUNCTION","INTERACTION WITH RRAGC AND RRAGD"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK089762","properties":[{"key":"ProteinId","value":"BAC40955.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK139756","properties":[{"key":"ProteinId","value":"BAE24128.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK144657","properties":[{"key":"ProteinId","value":"BAE25994.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK152221","properties":[{"key":"ProteinId","value":"BAE31048.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL671995","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC056358","properties":[{"key":"ProteinId","value":"AAH56358.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC063047","properties":[{"key":"ProteinId","value":"AAH63047.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"S76673","properties":[{"key":"ProteinId","value":"AAB21130.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS52984.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-1"},{"database":"CCDS","id":"CCDS52985.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-4"},{"database":"CCDS","id":"CCDS72332.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-2"},{"database":"CCDS","id":"CCDS72333.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-3"},{"database":"PIR","id":"A42029","properties":[{"key":"EntryName","value":"A42029"}]},{"database":"RefSeq","id":"NP_001098666.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001105196.1"}]},{"database":"RefSeq","id":"NP_001098667.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001105197.1"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"NP_001258418.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001271489.1"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"NP_001258419.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001271490.1"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"NP_001258420.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001271491.1"}],"isoformId":"Q64092-3"},{"database":"RefSeq","id":"NP_766060.2","properties":[{"key":"NucleotideSequenceId","value":"NM_172472.3"}]},{"database":"RefSeq","id":"XP_006527641.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006527578.3"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"XP_017173942.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017318453.3"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"XP_017173943.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017318454.3"}],"isoformId":"Q64092-3"},{"database":"RefSeq","id":"XP_036017791.1","properties":[{"key":"NucleotideSequenceId","value":"XM_036161898.1"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"XP_036017792.1","properties":[{"key":"NucleotideSequenceId","value":"XM_036161899.1"}],"isoformId":"Q64092-2"},{"database":"RefSeq","id":"XP_036017793.1","properties":[{"key":"NucleotideSequenceId","value":"XM_036161900.1"}],"isoformId":"Q64092-3"},{"database":"AlphaFoldDB","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"229078","properties":[{"key":"Interactions","value":"326"}]},{"database":"FunCoup","id":"Q64092","properties":[{"key":"Number of interactors","value":"2804"}]},{"database":"IntAct","id":"Q64092","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"10090.ENSMUSP00000076864","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q64092","properties":[{"key":"glycosylation","value":"6 sites, 1 O-linked glycan (5 sites)"}]},{"database":"iPTMnet","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000076864","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"263164","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-1"},{"database":"ProteomicsDB","id":"263165","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-2"},{"database":"ProteomicsDB","id":"263166","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-3"},{"database":"ProteomicsDB","id":"263167","properties":[{"key":"Description","value":"-"}],"isoformId":"Q64092-4"},{"database":"Pumba","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"11943","properties":[{"key":"antibodies","value":"457 antibodies from 42 providers"}]},{"database":"DNASU","id":"209446","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000101695.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000099219.3"},{"key":"GeneId","value":"ENSMUSG00000000134.18"}],"isoformId":"Q64092-2"},{"database":"Ensembl","id":"ENSMUST00000115677.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000111341.2"},{"key":"GeneId","value":"ENSMUSG00000000134.18"}],"isoformId":"Q64092-2"},{"database":"Ensembl","id":"ENSMUST00000115678.3","properties":[{"key":"ProteinId","value":"ENSMUSP00000111342.3"},{"key":"GeneId","value":"ENSMUSG00000000134.18"}],"isoformId":"Q64092-3"},{"database":"Ensembl","id":"ENSMUST00000115679.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000111343.2"},{"key":"GeneId","value":"ENSMUSG00000000134.18"}],"isoformId":"Q64092-2"},{"database":"Ensembl","id":"ENSMUST00000137467.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000134125.2"},{"key":"GeneId","value":"ENSMUSG00000000134.18"}],"isoformId":"Q64092-2"},{"database":"GeneID","id":"209446","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:209446","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009smg.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q64092-1"},{"database":"UCSC","id":"uc009smk.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q64092-3"},{"database":"AGR","id":"MGI:98511","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"7030","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:98511","properties":[{"key":"GeneName","value":"Tfe3"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000000134","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1318","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157503","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_031638_3_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ATFHAGE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"88425at9989","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"209446","properties":[{"key":"hits","value":"5 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q64092","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"Q64092","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000000134","properties":[{"key":"ExpressionPatterns","value":"Expressed in animal zygote and 223 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q64092","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21209915"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27913603"}]},{"database":"GO","id":"GO:0005765","properties":[{"key":"GoTerm","value":"C:lysosomal membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21209915"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27913603"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IC:MGI"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"15994295"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15994295"}]},{"database":"GO","id":"GO:0003700","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16936731"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27913603"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070888","properties":[{"key":"GoTerm","value":"F:E-box binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20713358"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"16936731"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:1990837","properties":[{"key":"GoTerm","value":"F:sequence-specific double-stranded DNA binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000976","properties":[{"key":"GoTerm","value":"F:transcription cis-regulatory region binding"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16936731"}]},{"database":"GO","id":"GO:0006959","properties":[{"key":"GoTerm","value":"P:humoral immune response"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16936731"}]},{"database":"GO","id":"GO:0007040","properties":[{"key":"GoTerm","value":"P:lysosome organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0120163","properties":[{"key":"GoTerm","value":"P:negative regulation of cold-induced thermogenesis"},{"key":"GoEvidenceType","value":"IMP:YuBioLab"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23885019"}]},{"database":"GO","id":"GO:0090336","properties":[{"key":"GoTerm","value":"P:positive regulation of brown fat cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27913603"}]},{"database":"GO","id":"GO:0045785","properties":[{"key":"GoTerm","value":"P:positive regulation of cell adhesion"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27913603"}]},{"database":"GO","id":"GO:0045944","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16936731"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20713358"}]},{"database":"GO","id":"GO:0045670","properties":[{"key":"GoTerm","value":"P:regulation of osteoclast differentiation"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"11930005"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd18928","properties":[{"key":"EntryName","value":"bHLHzip_TFE3"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.280.10:FF:000003","properties":[{"key":"EntryName","value":"microphthalmia-associated transcription factor isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR024100","properties":[{"key":"EntryName","value":"bHLHzip_TFE3"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR021802","properties":[{"key":"EntryName","value":"MiT/TFE_C"}]},{"database":"InterPro","id":"IPR031867","properties":[{"key":"EntryName","value":"MiT/TFE_N"}]},{"database":"PANTHER","id":"PTHR45776","properties":[{"key":"EntryName","value":"MIP04163P"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR45776:SF3","properties":[{"key":"EntryName","value":"TRANSCRIPTION FACTOR E3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11851","properties":[{"key":"EntryName","value":"DUF3371"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00010","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15951","properties":[{"key":"EntryName","value":"MITF_TFEB_C_3_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLLPESGIVADIELENILDPDSFYELKSQPLFLRSSLPISLQATPTTPATLSASSSAGGSRTPAMSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEMLSYLPGGTAGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVSDSLKPEQLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEES","length":572,"molWeight":61536,"crc64":"DAB0487EC0F6E92D","md5":"A98891DD4CA403FD21BEF9C43D8043FD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"INDUCTION":1,"PTM":3,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Region":6,"Motif":1,"Compositional bias":4,"Modified residue":9,"Cross-link":1,"Alternative sequence":2,"Mutagenesis":1,"Sequence conflict":5},"uniParcId":"UPI00001B9826"}}