{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q62311","uniProtkbId":"TAF6_MOUSE","entryAudit":{"firstPublicDate":"1998-07-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":192,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transcription initiation factor TFIID subunit 6"}},"alternativeNames":[{"fullName":{"value":"Transcription initiation factor TFIID 70 kDa subunit"},"shortNames":[{"value":"TAF(II)70"},{"value":"TAFII-70"},{"value":"TAFII70"}]},{"fullName":{"value":"Transcription initiation factor TFIID 80 kDa subunit"},"shortNames":[{"value":"TAF(II)80"},{"value":"TAFII-80"},{"value":"TAFII80"}]},{"fullName":{"value":"p80"}}]},"genes":[{"geneName":{"value":"Taf6"},"synonyms":[{"value":"Taf2e"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49848"}],"value":"The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF6 homodimer connects TFIID modules, forming a rigid core"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49848"}],"value":"Component of the TFIID basal transcription factor complex, composed of TATA-box-binding protein TBP, and a number of TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 and TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TBP-free TAFII-histone acetylase complex (TFTC-HAT) (By similarity). Interacts with TP53/p53 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TAF6 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"Transcription initiation factor TFIID subunit 6","featureId":"PRO_0000118874"},{"type":"Region","location":{"start":{"value":142,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":611,"modifier":"EXACT"},"end":{"value":678,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":542,"modifier":"EXACT"},"end":{"value":574,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":633,"modifier":"EXACT"},"end":{"value":646,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49848"}]},{"type":"Modified residue","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63801"}]},{"type":"Modified residue","location":{"start":{"value":253,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63801"}]},{"type":"Modified residue","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":264,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q63801"}]},{"type":"Modified residue","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":524,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":626,"modifier":"EXACT"},"end":{"value":626,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":634,"modifier":"EXACT"},"end":{"value":634,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":636,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49848"}]},{"type":"Modified residue","location":{"start":{"value":653,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":660,"modifier":"EXACT"},"end":{"value":660,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Cross-link","location":{"start":{"value":196,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P49848"}]}],"keywords":[{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"7665100","citationType":"journal article","authors":["Umehara T.","Kida S.","Horikoshi M."],"citationCrossReferences":[{"database":"PubMed","id":"7665100"},{"database":"DOI","id":"10.1016/0378-1119(95)00285-e"}],"title":"Isolation of a cDNA encoding a mouse TFIID subunit containing histone H4 homology.","publicationDate":"1995","journal":"Gene","firstPage":"301","lastPage":"302","volume":"161"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"FVB/N-3","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-626; SER-634; SER-653 AND THR-660","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-524","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryo","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D49439","properties":[{"key":"ProteinId","value":"BAA08417.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058583","properties":[{"key":"ProteinId","value":"AAH58583.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS19795.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"JC4245","properties":[{"key":"EntryName","value":"JC4245"}]},{"database":"RefSeq","id":"NP_001343529.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001356600.2"}]},{"database":"RefSeq","id":"NP_001343530.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001356601.2"}]},{"database":"RefSeq","id":"NP_001343531.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001356602.2"}]},{"database":"RefSeq","id":"NP_033341.1","properties":[{"key":"NucleotideSequenceId","value":"NM_009315.5"}]},{"database":"RefSeq","id":"XP_030110213.1","properties":[{"key":"NucleotideSequenceId","value":"XM_030254353.2"}]},{"database":"RefSeq","id":"XP_030110214.1","properties":[{"key":"NucleotideSequenceId","value":"XM_030254354.2"}]},{"database":"AlphaFoldDB","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"203959","properties":[{"key":"Interactions","value":"6"}]},{"database":"ComplexPortal","id":"CPX-916","properties":[{"key":"EntryName","value":"TFTC histone acetylation complex"}]},{"database":"ComplexPortal","id":"CPX-932","properties":[{"key":"EntryName","value":"General transcription factor complex TFIID"}]},{"database":"ComplexPortal","id":"CPX-959","properties":[{"key":"EntryName","value":"General transcription factor complex TFIID, Taf4b variant"}]},{"database":"CORUM","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-493N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q62311","properties":[{"key":"Number of interactors","value":"3228"}]},{"database":"IntAct","id":"Q62311","properties":[{"key":"Interactions","value":"3"}]},{"database":"MINT","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000106561","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q62311","properties":[{"key":"glycosylation","value":"7 sites, 1 O-linked glycan (7 sites)"}]},{"database":"iPTMnet","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000106561","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"254815","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"1765","properties":[{"key":"antibodies","value":"202 antibodies from 24 providers"}]},{"database":"DNASU","id":"21343","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000048698.14","properties":[{"key":"ProteinId","value":"ENSMUSP00000048016.8"},{"key":"GeneId","value":"ENSMUSG00000036980.14"}]},{"database":"Ensembl","id":"ENSMUST00000110936.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000106561.2"},{"key":"GeneId","value":"ENSMUSG00000036980.14"}]},{"database":"GeneID","id":"21343","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:21343","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009aew.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:109129","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6878","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:109129","properties":[{"key":"GeneName","value":"Taf6"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000036980","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2549","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00640000091486","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_021711_2_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MPEETCQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"361039at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-674695","properties":[{"key":"PathwayName","value":"RNA Polymerase II Pre-transcription Events"}]},{"database":"Reactome","id":"R-MMU-6804756","properties":[{"key":"PathwayName","value":"Regulation of TP53 Activity through Phosphorylation"}]},{"database":"Reactome","id":"R-MMU-6807505","properties":[{"key":"PathwayName","value":"RNA polymerase II transcribes snRNA genes"}]},{"database":"Reactome","id":"R-MMU-73776","properties":[{"key":"PathwayName","value":"RNA Polymerase II Promoter Escape"}]},{"database":"Reactome","id":"R-MMU-73779","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"}]},{"database":"Reactome","id":"R-MMU-75953","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Initiation"}]},{"database":"Reactome","id":"R-MMU-76042","properties":[{"key":"PathwayName","value":"RNA Polymerase II Transcription Initiation And Promoter Clearance"}]},{"database":"BioGRID-ORCS","id":"21343","properties":[{"key":"hits","value":"23 hits in 83 CRISPR screens"}]},{"database":"PRO","id":"PR:Q62311","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"RNAct","id":"Q62311","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000036980","properties":[{"key":"ExpressionPatterns","value":"Expressed in undifferentiated genital tubercle and 241 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q62311","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0071339","properties":[{"key":"GoTerm","value":"C:MLL1 complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"12665565"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17242199"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18722179"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22323595"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000124","properties":[{"key":"GoTerm","value":"C:SAGA complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0046695","properties":[{"key":"GoTerm","value":"C:SLIK (SAGA-like) complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005669","properties":[{"key":"GoTerm","value":"C:transcription factor TFIID complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"14580349"}]},{"database":"GO","id":"GO:0033276","properties":[{"key":"GoTerm","value":"C:transcription factor TFTC complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0017162","properties":[{"key":"GoTerm","value":"F:aryl hydrocarbon receptor binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003677","properties":[{"key":"GoTerm","value":"F:DNA binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18722179"}]},{"database":"GO","id":"GO:0046982","properties":[{"key":"GoTerm","value":"F:protein heterodimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0016251","properties":[{"key":"GoTerm","value":"F:RNA polymerase II general transcription initiation factor activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0003713","properties":[{"key":"GoTerm","value":"F:transcription coactivator activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006352","properties":[{"key":"GoTerm","value":"P:DNA-templated transcription initiation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042789","properties":[{"key":"GoTerm","value":"P:mRNA transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045786","properties":[{"key":"GoTerm","value":"P:negative regulation of cell cycle"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0008285","properties":[{"key":"GoTerm","value":"P:negative regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"18206972"}]},{"database":"GO","id":"GO:2001244","properties":[{"key":"GoTerm","value":"P:positive regulation of intrinsic apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0060261","properties":[{"key":"GoTerm","value":"P:positive regulation of transcription initiation by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0006282","properties":[{"key":"GoTerm","value":"P:regulation of DNA repair"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"11406595"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0051123","properties":[{"key":"GoTerm","value":"P:RNA polymerase II preinitiation complex assembly"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0006367","properties":[{"key":"GoTerm","value":"P:transcription initiation at RNA polymerase II promoter"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"CDD","id":"cd22931","properties":[{"key":"EntryName","value":"HFD_TAF6"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd08050","properties":[{"key":"EntryName","value":"TAF6C"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.20.10:FF:000030","properties":[{"key":"EntryName","value":"Transcription initiation factor TFIID subunit 6"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.25.40.770:FF:000001","properties":[{"key":"EntryName","value":"Transcription initiation factor TFIID subunit 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.20.10","properties":[{"key":"EntryName","value":"Histone, subunit A"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.770","properties":[{"key":"EntryName","value":"TAF6, C-terminal HEAT repeat domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR009072","properties":[{"key":"EntryName","value":"Histone-fold"}]},{"database":"InterPro","id":"IPR037796","properties":[{"key":"EntryName","value":"TAF6"}]},{"database":"InterPro","id":"IPR011442","properties":[{"key":"EntryName","value":"TAF6_C"}]},{"database":"InterPro","id":"IPR046344","properties":[{"key":"EntryName","value":"TAF6_C_sf"}]},{"database":"InterPro","id":"IPR004823","properties":[{"key":"EntryName","value":"TAF_TATA-bd_Histone-like_dom"}]},{"database":"PANTHER","id":"PTHR10221","properties":[{"key":"EntryName","value":"TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10221:SF9","properties":[{"key":"EntryName","value":"TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02969","properties":[{"key":"EntryName","value":"TAF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF07571","properties":[{"key":"EntryName","value":"TAF6_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00803","properties":[{"key":"EntryName","value":"TAF"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47113","properties":[{"key":"EntryName","value":"Histone-fold"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRGEFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGSGSVQKYIVVSLPPTGEGKGGPPSHPSPVPPSSSSPSPLGGSTLCGGKQEAGDSPPPAPGTPKANGSQPTGPGSPQPAL","length":678,"molWeight":72673,"crc64":"2F454DA3A29B410D","md5":"803CC09F7B590389A518B0ABC2DC0BAE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":3,"Compositional bias":3,"Modified residue":10,"Cross-link":1},"uniParcId":"UPI0000026C7E"}}