{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q62302","uniProtkbId":"TX261_MOUSE","entryAudit":{"firstPublicDate":"2006-07-25","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1996-11-01","entryVersion":138,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein TEX261"}},"alternativeNames":[{"fullName":{"value":"Testis-expressed protein 261"}}]},"genes":[{"geneName":{"value":"Tex261"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8703127"}],"value":"Detected in testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"Not detectable in testis from 6 day old animals. Detectable in testis 15 days after birth. Highly expressed in testis 20 days after birth. Highly expressed in meiotic and post-meiotic germ cells"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SVP26 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"Protein TEX261","featureId":"PRO_0000247434"},{"type":"Transmembrane","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":42,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"8703127","citationType":"journal article","authors":["Lopez-Fernandez L.A.","del Mazo J."],"citationCrossReferences":[{"database":"PubMed","id":"8703127"},{"database":"DOI","id":"10.1007/s003359900210"}],"title":"Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library.","publicationDate":"1996","journal":"Mamm. Genome","firstPage":"698","lastPage":"700","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY"],"referenceComments":[{"value":"SWR/J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"9464256","citationType":"journal article","authors":["Lopez-Fernandez L.A.","Parragao M.","del Mazo J."],"citationCrossReferences":[{"database":"PubMed","id":"9464256"},{"database":"DOI","id":"10.1006/bbrc.1997.7971"}],"title":"Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (stAR) gene, is regulated during the development of germ cells.","publicationDate":"1998","journal":"Biochem. Biophys. Res. Commun.","firstPage":"565","lastPage":"569","volume":"242"},"referencePositions":["DEVELOPMENTAL REGULATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"X81058","properties":[{"key":"ProteinId","value":"CAA56947.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK149789","properties":[{"key":"ProteinId","value":"BAE29086.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC003802","properties":[{"key":"ProteinId","value":"AAH03802.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS20285.1","properties":[{"key":"Description","value":"-"}]},{"database":"PIR","id":"S47481","properties":[{"key":"EntryName","value":"S47481"}]},{"database":"RefSeq","id":"NP_033383.1","properties":[{"key":"NucleotideSequenceId","value":"NM_009357.2"}]},{"database":"AlphaFoldDB","id":"Q62302","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q62302","properties":[{"key":"Number of interactors","value":"926"}]},{"database":"STRING","id":"10090.ENSMUSP00000014892","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q62302","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"PhosphoSitePlus","id":"Q62302","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000014892","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"297758","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"21766","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000014892.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000014892.7"},{"key":"GeneId","value":"ENSMUSG00000014748.14"}]},{"database":"GeneID","id":"21766","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:21766","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009cof.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1096575","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"113419","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1096575","properties":[{"key":"GeneName","value":"Tex261"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000014748","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4136","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000010888","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_058268_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q62302","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TMGTEPV","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"28257at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q62302","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"21766","properties":[{"key":"hits","value":"3 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q62302","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q62302","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000014748","properties":[{"key":"ExpressionPatterns","value":"Expressed in ileal epithelium and 261 other cell types or tissues"}]},{"database":"GO","id":"GO:0030134","properties":[{"key":"GoTerm","value":"C:COPII-coated ER to Golgi transport vesicle"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0097020","properties":[{"key":"GoTerm","value":"F:COPII receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006888","properties":[{"key":"GoTerm","value":"P:endoplasmic reticulum to Golgi vesicle-mediated transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"17803966"}]},{"database":"InterPro","id":"IPR007277","properties":[{"key":"EntryName","value":"Svp26/Tex261"}]},{"database":"PANTHER","id":"PTHR13144:SF0","properties":[{"key":"EntryName","value":"PROTEIN TEX261"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13144","properties":[{"key":"EntryName","value":"TEX261 PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04148","properties":[{"key":"EntryName","value":"Erv26"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MWFMYVLSWLSLFIQVAFITLAVAAGLYYLAELIEEYTVATSRIIKYMIWFSTAVLIGLYVFERFPTSMIGVGLFTNLVYFGLLQTFPFIMLTSPNFILSCGLVVVNHYLAFQFFAEEYYPFSEVLAYFTFCLWIIPFAFFVSLSAGENVLPSTMQPGDDVVSNYFTKGKRGKRLGILVVFSFIKEAILPSRQKIY","length":196,"molWeight":22524,"crc64":"94ACEE3E5232E6A4","md5":"F7CC80839929A1F88909C16C8CEBBA81"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":5},"uniParcId":"UPI0000021361"}}