{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q62205","secondaryAccessions":["A2ASI7","Q5DTI0"],"uniProtkbId":"SCN9A_MOUSE","entryAudit":{"firstPublicDate":"2004-11-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-09","entryVersion":184,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}],"value":"Sodium channel protein type 9 subunit alpha"}},"alternativeNames":[{"fullName":{"value":"Peripheral sodium channel 1"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O08562"}],"value":"PN1"}]},{"fullName":{"value":"Sodium channel protein type IX subunit alpha"}},{"fullName":{"value":"Voltage-gated sodium channel subunit alpha Nav1.7"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:107636"}],"value":"Scn9a"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"value":"Kiaa4197"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15314237"}],"value":"Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed:15314237)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123669"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37117223"}],"value":"The Nav1.7 voltage-gated sodium channel consists of an ion-conducting alpha subunit SCN9A which is functional on its own regulated by one or more beta-1 (SCN1B), beta-2 (SCN2B), beta-3 (SCN3B) and beta-4 (SCN4B) subunits (By similarity). SCN1B and SCN3B are non-covalently associated with SCN9A (By similarity). SCN2B and SCN4B are disulfide-linked to SCN9A (By similarity). SCN1B regulates channel inactivation (By similarity). Interacts with NEDD4 and NEDD4L; regulates Nav1.7 activity most probably through ubiquitination and subsequent endocytosis (PubMed:15123669). Interacts with TMEM233; modulates the gating properties of NaV1.7 (PubMed:37117223)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}],"value":"Localizes to neuron terminals. Also detected at Nodes of Ranvier"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123669"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}],"value":"Cell projection, neuron projection","id":"SL-0518"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}],"value":"Cell projection, axon","id":"SL-0279"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31647222"}],"value":"Expressed strongly in sciatic nerves, with moderate levels in kidney (PubMed:31647222). Not detected in liver, brain and muscle (PubMed:31647222)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"},{"evidenceCode":"ECO:0000305"}],"value":"The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4) (By similarity). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123669"}],"value":"Ubiquitinated by NEDD4L; which may promote its endocytosis"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}],"value":"Phosphorylation at Ser-1488 by PKC in a highly conserved cytoplasmic loop increases peak sodium currents"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1984,"modifier":"EXACT"}},"description":"Sodium channel protein type 9 subunit alpha","featureId":"PRO_0000048503"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":145,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":185,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":204,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":346,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Intramembrane","location":{"start":{"value":347,"modifier":"EXACT"},"end":{"value":363,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":402,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":403,"modifier":"EXACT"},"end":{"value":744,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":745,"modifier":"EXACT"},"end":{"value":761,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":762,"modifier":"EXACT"},"end":{"value":770,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":771,"modifier":"EXACT"},"end":{"value":795,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":796,"modifier":"EXACT"},"end":{"value":804,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":805,"modifier":"EXACT"},"end":{"value":821,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":822,"modifier":"EXACT"},"end":{"value":830,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":831,"modifier":"EXACT"},"end":{"value":847,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":848,"modifier":"EXACT"},"end":{"value":864,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":865,"modifier":"EXACT"},"end":{"value":887,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":888,"modifier":"EXACT"},"end":{"value":914,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Intramembrane","location":{"start":{"value":915,"modifier":"EXACT"},"end":{"value":927,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":928,"modifier":"EXACT"},"end":{"value":939,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":940,"modifier":"EXACT"},"end":{"value":966,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":967,"modifier":"EXACT"},"end":{"value":1185,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1186,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1211,"modifier":"EXACT"},"end":{"value":1222,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1223,"modifier":"EXACT"},"end":{"value":1248,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1249,"modifier":"EXACT"},"end":{"value":1250,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1251,"modifier":"EXACT"},"end":{"value":1276,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1277,"modifier":"EXACT"},"end":{"value":1285,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1286,"modifier":"EXACT"},"end":{"value":1302,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1303,"modifier":"EXACT"},"end":{"value":1315,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1316,"modifier":"EXACT"},"end":{"value":1340,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1341,"modifier":"EXACT"},"end":{"value":1392,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Intramembrane","location":{"start":{"value":1393,"modifier":"EXACT"},"end":{"value":1403,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1404,"modifier":"EXACT"},"end":{"value":1429,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1430,"modifier":"EXACT"},"end":{"value":1455,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1456,"modifier":"EXACT"},"end":{"value":1512,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1513,"modifier":"EXACT"},"end":{"value":1532,"modifier":"EXACT"}},"description":"Helical; Name=S1 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1533,"modifier":"EXACT"},"end":{"value":1543,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1544,"modifier":"EXACT"},"end":{"value":1565,"modifier":"EXACT"}},"description":"Helical; Name=S2 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1566,"modifier":"EXACT"},"end":{"value":1574,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1575,"modifier":"EXACT"},"end":{"value":1596,"modifier":"EXACT"}},"description":"Helical; Name=S3 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1597,"modifier":"EXACT"},"end":{"value":1605,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1606,"modifier":"EXACT"},"end":{"value":1625,"modifier":"EXACT"}},"description":"Helical; Name=S4 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1626,"modifier":"EXACT"},"end":{"value":1638,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1639,"modifier":"EXACT"},"end":{"value":1661,"modifier":"EXACT"}},"description":"Helical; Name=S5 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1662,"modifier":"EXACT"},"end":{"value":1684,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Intramembrane","location":{"start":{"value":1685,"modifier":"EXACT"},"end":{"value":1697,"modifier":"EXACT"}},"description":"Pore-forming","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1698,"modifier":"EXACT"},"end":{"value":1731,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Transmembrane","location":{"start":{"value":1732,"modifier":"EXACT"},"end":{"value":1757,"modifier":"EXACT"}},"description":"Helical; Name=S6 of repeat IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Topological domain","location":{"start":{"value":1758,"modifier":"EXACT"},"end":{"value":1984,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Repeat","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":410,"modifier":"EXACT"}},"description":"I","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Repeat","location":{"start":{"value":725,"modifier":"EXACT"},"end":{"value":988,"modifier":"EXACT"}},"description":"II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Repeat","location":{"start":{"value":1178,"modifier":"EXACT"},"end":{"value":1486,"modifier":"EXACT"}},"description":"III","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Repeat","location":{"start":{"value":1495,"modifier":"EXACT"},"end":{"value":1793,"modifier":"EXACT"}},"description":"IV","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Domain","location":{"start":{"value":1887,"modifier":"EXACT"},"end":{"value":1916,"modifier":"EXACT"}},"description":"IQ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00116"}]},{"type":"Region","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":55,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":540,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1015,"modifier":"EXACT"},"end":{"value":1039,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1089,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1933,"modifier":"EXACT"},"end":{"value":1984,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":449,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":458,"modifier":"EXACT"},"end":{"value":471,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":474,"modifier":"EXACT"},"end":{"value":486,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":574,"modifier":"EXACT"},"end":{"value":584,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1035,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1135,"modifier":"EXACT"},"end":{"value":1145,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1946,"modifier":"EXACT"},"end":{"value":1958,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1960,"modifier":"EXACT"},"end":{"value":1984,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Site","location":{"start":{"value":821,"modifier":"EXACT"},"end":{"value":821,"modifier":"EXACT"}},"description":"Is directly targeted by the spider protoxin-II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Site","location":{"start":{"value":826,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"Is directly targeted by the spider protoxin-II","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Modified residue","location":{"start":{"value":1488,"modifier":"EXACT"},"end":{"value":1488,"modifier":"EXACT"}},"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Glycosylation","location":{"start":{"value":283,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1350,"modifier":"EXACT"},"end":{"value":1350,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1364,"modifier":"EXACT"},"end":{"value":1364,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":1373,"modifier":"EXACT"},"end":{"value":1373,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":275,"modifier":"EXACT"},"end":{"value":324,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Disulfide bond","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Interchain; with SCN2B or SCN4B","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04775"}]},{"type":"Disulfide bond","location":{"start":{"value":894,"modifier":"EXACT"},"end":{"value":894,"modifier":"EXACT"}},"description":"Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P04775"}]},{"type":"Disulfide bond","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":902,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Disulfide bond","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":943,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Disulfide bond","location":{"start":{"value":1348,"modifier":"EXACT"},"end":{"value":1368,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]},{"type":"Disulfide bond","location":{"start":{"value":1713,"modifier":"EXACT"},"end":{"value":1728,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q15858"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0915","category":"Ligand","name":"Sodium"},{"id":"KW-0894","category":"Molecular function","name":"Sodium channel"},{"id":"KW-0739","category":"Biological process","name":"Sodium transport"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0851","category":"Molecular function","name":"Voltage-gated channel"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"CI-EPOF7MDANTHHR","citationType":"submission","authors":["Jover E.","Shah V."],"title":"Mouse sodium channel 25 in m13mp19.","publicationDate":"MAY-1995","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 1675-1983"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-C3VEIMGK1G3LQ","citationType":"submission","authors":["Okazaki N.","Kikuno R.F.","Ohara R.","Inamoto S.","Nagase T.","Ohara O.","Koga H."],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"FEB-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1740-1983"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15123669","citationType":"journal article","authors":["Fotia A.B.","Ekberg J.","Adams D.J.","Cook D.I.","Poronnik P.","Kumar S."],"citationCrossReferences":[{"database":"PubMed","id":"15123669"},{"database":"DOI","id":"10.1074/jbc.m402820200"}],"title":"Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.","publicationDate":"2004","journal":"J. Biol. Chem.","firstPage":"28930","lastPage":"28935","volume":"279"},"referencePositions":["SUBCELLULAR LOCATION","INTERACTION WITH NEDD4 AND NEDD4L","UBIQUITINATION"]},{"referenceNumber":5,"citation":{"id":"15314237","citationType":"journal article","authors":["Nassar M.A.","Stirling L.C.","Forlani G.","Baker M.D.","Matthews E.A.","Dickenson A.H.","Wood J.N."],"citationCrossReferences":[{"database":"PubMed","id":"15314237"},{"database":"DOI","id":"10.1073/pnas.0404915101"}],"title":"Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12706","lastPage":"12711","volume":"101"},"referencePositions":["FUNCTION IN INFLAMMATORY PAIN"]},{"referenceNumber":6,"citation":{"id":"31647222","citationType":"journal article","authors":["Gonzales J.","Demetrio de Souza Franca P.","Jiang Y.","Pirovano G.","Kossatz S.","Guru N.","Yarilin D.","Agwa A.J.","Schroeder C.I.","Patel S.G.","Ganly I.","King G.F.","Reiner T."],"citationCrossReferences":[{"database":"PubMed","id":"31647222"},{"database":"DOI","id":"10.1021/acs.bioconjchem.9b00612"}],"title":"Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide.","publicationDate":"2019","journal":"Bioconj. Chem.","firstPage":"2879","lastPage":"2888","volume":"30"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":7,"citation":{"id":"37117223","citationType":"journal article","authors":["Jami S.","Deuis J.R.","Klasfauseweh T.","Cheng X.","Kurdyukov S.","Chung F.","Okorokov A.L.","Li S.","Zhang J.","Cristofori-Armstrong B.","Israel M.R.","Ju R.J.","Robinson S.D.","Zhao P.","Ragnarsson L.","Andersson A.","Tran P.","Schendel V.","McMahon K.L.","Tran H.N.T.","Chin Y.K.","Zhu Y.","Liu J.","Crawford T.","Purushothamvasan S.","Habib A.M.","Andersson D.A.","Rash L.D.","Wood J.N.","Zhao J.","Stehbens S.J.","Mobli M.","Leffler A.","Jiang D.","Cox J.J.","Waxman S.G.","Dib-Hajj S.D.","Gregory Neely G.","Durek T.","Vetter I."],"citationCrossReferences":[{"database":"PubMed","id":"37117223"},{"database":"DOI","id":"10.1038/s41467-023-37963-2"}],"title":"Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.","publicationDate":"2023","journal":"Nat. Commun.","firstPage":"2442","lastPage":"2442","volume":"14"},"referencePositions":["SUBUNIT"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL928623","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL928726","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"L42338","properties":[{"key":"ProteinId","value":"AAA67106.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK220540","properties":[{"key":"ProteinId","value":"BAD90315.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS71063.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001277603.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001290674.1"}]},{"database":"AlphaFoldDB","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"203104","properties":[{"key":"Interactions","value":"15"}]},{"database":"FunCoup","id":"Q62205","properties":[{"key":"Number of interactors","value":"440"}]},{"database":"IntAct","id":"Q62205","properties":[{"key":"Interactions","value":"1"}]},{"database":"MINT","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000097642","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL3414411","properties":[{"key":"Description","value":"-"}]},{"database":"DrugCentral","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"GuidetoPHARMACOLOGY","id":"584","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q62205","properties":[{"key":"glycosylation","value":"7 sites, 5 N-linked glycans (7 sites)"}]},{"database":"iPTMnet","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000097642","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"256751","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q62205","properties":[{"key":"antibodies","value":"1 sequenced antibody"}]},{"database":"Antibodypedia","id":"33781","properties":[{"key":"antibodies","value":"499 antibodies from 40 providers"}]},{"database":"DNASU","id":"20274","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000100064.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000097642.3"},{"key":"GeneId","value":"ENSMUSG00000075316.14"}]},{"database":"GeneID","id":"20274","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:20274","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008jxe.4","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:107636","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"6335","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:107636","properties":[{"key":"GeneName","value":"Scn9a"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000075316","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2301","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000161368","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VPHRPKE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2984333at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"20274","properties":[{"key":"hits","value":"1 hit in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q62205","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q62205","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000075316","properties":[{"key":"ExpressionPatterns","value":"Expressed in lumbar dorsal root ganglion and 73 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q62205","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030424","properties":[{"key":"GoTerm","value":"C:axon"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043679","properties":[{"key":"GoTerm","value":"C:axon terminus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033268","properties":[{"key":"GoTerm","value":"C:node of Ranvier"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15123669"}]},{"database":"GO","id":"GO:0001518","properties":[{"key":"GoTerm","value":"C:voltage-gated sodium channel complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005272","properties":[{"key":"GoTerm","value":"F:sodium channel activity"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005248","properties":[{"key":"GoTerm","value":"F:voltage-gated sodium channel activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098870","properties":[{"key":"GoTerm","value":"P:action potential propagation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061368","properties":[{"key":"GoTerm","value":"P:behavioral response to formalin induced pain"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0048266","properties":[{"key":"GoTerm","value":"P:behavioral response to pain"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314237"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24440715"}]},{"database":"GO","id":"GO:0007623","properties":[{"key":"GoTerm","value":"P:circadian rhythm"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25101983"}]},{"database":"GO","id":"GO:0050974","properties":[{"key":"GoTerm","value":"P:detection of mechanical stimulus involved in sensory perception"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25101983"}]},{"database":"GO","id":"GO:0050965","properties":[{"key":"GoTerm","value":"P:detection of temperature stimulus involved in sensory perception of pain"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25101983"}]},{"database":"GO","id":"GO:0006954","properties":[{"key":"GoTerm","value":"P:inflammatory response"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314237"}]},{"database":"GO","id":"GO:0086010","properties":[{"key":"GoTerm","value":"P:membrane depolarization during action potential"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045759","properties":[{"key":"GoTerm","value":"P:negative regulation of action potential"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019228","properties":[{"key":"GoTerm","value":"P:neuronal action potential"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0009791","properties":[{"key":"GoTerm","value":"P:post-embryonic development"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15314237"}]},{"database":"GO","id":"GO:0009636","properties":[{"key":"GoTerm","value":"P:response to toxic substance"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16029194"}]},{"database":"GO","id":"GO:0019233","properties":[{"key":"GoTerm","value":"P:sensory perception of pain"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035725","properties":[{"key":"GoTerm","value":"P:sodium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd13433","properties":[{"key":"EntryName","value":"Na_channel_gate"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.10:FF:000002","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000001","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.287.70:FF:000006","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000002","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000004","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000005","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.5.1190:FF:000001","properties":[{"key":"EntryName","value":"Sodium channel protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.20.120.350:FF:000003","properties":[{"key":"EntryName","value":"Voltage-dependent sodium channel"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"4"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.5.1190","properties":[{"key":"EntryName","value":"iswi atpase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.20.120.350","properties":[{"key":"EntryName","value":"Voltage-gated potassium channels. Chain C"},{"key":"MatchStatus","value":"4"}]},{"database":"InterPro","id":"IPR005821","properties":[{"key":"EntryName","value":"Ion_trans_dom"}]},{"database":"InterPro","id":"IPR000048","properties":[{"key":"EntryName","value":"IQ_motif_EF-hand-BS"}]},{"database":"InterPro","id":"IPR058542","properties":[{"key":"EntryName","value":"IQ_SCN5A_C"}]},{"database":"InterPro","id":"IPR001696","properties":[{"key":"EntryName","value":"Na_channel_asu"}]},{"database":"InterPro","id":"IPR044564","properties":[{"key":"EntryName","value":"Na_chnl_inactivation_gate"}]},{"database":"InterPro","id":"IPR010526","properties":[{"key":"EntryName","value":"Na_trans_assoc_dom"}]},{"database":"InterPro","id":"IPR024583","properties":[{"key":"EntryName","value":"Na_trans_cytopl"}]},{"database":"InterPro","id":"IPR043203","properties":[{"key":"EntryName","value":"VGCC_Ca_Na"}]},{"database":"InterPro","id":"IPR027359","properties":[{"key":"EntryName","value":"Volt_channel_dom_sf"}]},{"database":"PANTHER","id":"PTHR10037:SF221","properties":[{"key":"EntryName","value":"SODIUM CHANNEL PROTEIN TYPE 9 SUBUNIT ALPHA"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10037","properties":[{"key":"EntryName","value":"VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00520","properties":[{"key":"EntryName","value":"Ion_trans"},{"key":"MatchStatus","value":"4"}]},{"database":"Pfam","id":"PF24609","properties":[{"key":"EntryName","value":"IQ_SCN5A_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06512","properties":[{"key":"EntryName","value":"Na_trans_assoc"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11933","properties":[{"key":"EntryName","value":"Na_trans_cytopl"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00170","properties":[{"key":"EntryName","value":"NACHANNEL"}]},{"database":"SMART","id":"SM00015","properties":[{"key":"EntryName","value":"IQ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF81324","properties":[{"key":"EntryName","value":"Voltage-gated potassium channels"},{"key":"MatchStatus","value":"4"}]}],"sequence":{"value":"MAMLPPPGPQSFVHFTKQSLALIEQRISEEKAKGHKDEKKDDEEEGPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKDLEQNETLESIMSTAESEEELKRYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDYGYTSFDTFGWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKLSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRAREKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKKFIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINENCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKRENYISNRTLAEISKDHNFLKEKDKISGFSSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLENMNTEELSSDSDSDYSKERRNRSSSSECSTVDNPLPGEEEAEAEPINADEPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFSVSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYMSFVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATIIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLPNKEDIVFDNVNENSSPEKTDATASTISPPSYDSVTKPDQEKYETDKTEKEDKEKDESRK","length":1984,"molWeight":225813,"crc64":"51A8DBA38EC7EF38","md5":"E15420118905F8756F625367D951E579"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DOMAIN":1,"PTM":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":29,"Transmembrane":24,"Intramembrane":4,"Repeat":4,"Domain":1,"Region":6,"Coiled coil":2,"Compositional bias":9,"Site":2,"Modified residue":1,"Glycosylation":4,"Disulfide bond":7},"uniParcId":"UPI000060418A"}}