{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q61908","uniProtkbId":"CMC4_MOUSE","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1996-11-01","entryVersion":155,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cx9C motif-containing protein 4"}},"alternativeNames":[{"fullName":{"value":"Mature T-cell proliferation 1 neighbor protein"}},{"fullName":{"value":"Mature T-cell proliferation-1 type A"},"shortNames":[{"value":"MTCP-1 type A"}]},{"fullName":{"value":"Protein p8 MTCP-1"},"shortNames":[{"value":"p8MTCP1"}]}]},"genes":[{"geneName":{"value":"Cmc4"},"synonyms":[{"value":"C6.1b"},{"value":"Mtcp1"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"7784073"}],"value":"Mitochondrion","id":"SL-0173"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Short"},{"value":"Type A"},{"value":"p8 MTCP-1"}],"isoformIds":["Q61908-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Long"},{"value":"Type B1"},{"value":"p13 MTCP-1"}],"isoformIds":["Q60945-1"],"isoformSequenceStatus":"External"}]},{"texts":[{"value":"Expressed in many tissues"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The twin Cx9C motifs are involved in the recognition by the mitochondrial disulfide relay system"}],"commentType":"DOMAIN"},{"texts":[{"value":"Shares a non-coding 5' exon with isoform 2 which is spliced to a different set of 3' exons encoding an unrelated protein"}],"commentType":"MISCELLANEOUS","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CMC4 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Cx9C motif-containing protein 4","featureId":"PRO_0000096615"},{"type":"Domain","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":46,"modifier":"EXACT"}},"description":"CHCH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01150"}]},{"type":"Motif","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":17,"modifier":"EXACT"}},"description":"Cx9C motif 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01150"}]},{"type":"Motif","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"Cx9C motif 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01150"}]},{"type":"Disulfide bond","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":38,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01150"}]},{"type":"Disulfide bond","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01150"}]},{"type":"Disulfide bond","location":{"start":{"value":39,"modifier":"EXACT"},"end":{"value":50,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"7970717","citationType":"journal article","authors":["Soulier J.","Madani A.","Cacheux V.","Rosenzwajg M.","Sigaux F.","Stern M.-H."],"citationCrossReferences":[{"database":"PubMed","id":"7970717"}],"title":"The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.","publicationDate":"1994","journal":"Oncogene","firstPage":"3565","lastPage":"3570","volume":"9"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"]},{"referenceNumber":2,"citation":{"id":"7784073","citationType":"journal article","authors":["Madani A.","Soulier J.","Schmid M.","Plichtova R.","Lerme F.","Gateau-Roesch O.","Garnier J.-P.","Pla M.","Sigaux F.","Stern M.-H."],"citationCrossReferences":[{"database":"PubMed","id":"7784073"}],"title":"The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein.","publicationDate":"1995","journal":"Oncogene","firstPage":"2259","lastPage":"2262","volume":"10"},"referencePositions":["SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z35294","properties":[{"key":"ProteinId","value":"CAA84544.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS41030.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q61908-1"},{"database":"PIR","id":"I48672","properties":[{"key":"EntryName","value":"I48672"}]},{"database":"RefSeq","id":"NP_001281206.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001294277.1"}],"isoformId":"Q61908-1"},{"database":"RefSeq","id":"NP_034969.1","properties":[{"key":"NucleotideSequenceId","value":"NM_010839.6"}],"isoformId":"Q61908-1"},{"database":"AlphaFoldDB","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q61908","properties":[{"key":"Number of interactors","value":"401"}]},{"database":"STRING","id":"10090.ENSMUSP00000033543","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000033543","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"283315","properties":[{"key":"Description","value":"-"}],"isoformId":"Q61908-1"},{"database":"Pumba","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"45442","properties":[{"key":"antibodies","value":"64 antibodies from 17 providers"}]},{"database":"Ensembl","id":"ENSMUST00000033543.14","properties":[{"key":"ProteinId","value":"ENSMUSP00000033543.8"},{"key":"GeneId","value":"ENSMUSG00000090110.9"}]},{"database":"Ensembl","id":"ENSMUST00000120286.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000112753.2"},{"key":"GeneId","value":"ENSMUSG00000090110.9"}]},{"database":"Ensembl","id":"ENSMUST00000149863.3","properties":[{"key":"ProteinId","value":"ENSMUSP00000117381.3"},{"key":"GeneId","value":"ENSMUSG00000090110.9"}]},{"database":"GeneID","id":"105886298","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:105886298","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009tpv.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q61908-1"},{"database":"AGR","id":"MGI:5637812","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"100272147","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:5637812","properties":[{"key":"GeneName","value":"Cmc4"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000090110","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SC73","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000012647","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_177210_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QANKYME","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"13601at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"105886298","properties":[{"key":"hits","value":"0 hits in 33 CRISPR screens"}]},{"database":"PRO","id":"PR:Q61908","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome X"}]},{"database":"RNAct","id":"Q61908","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000090110","properties":[{"key":"ExpressionPatterns","value":"Expressed in primary oocyte and 254 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q61908","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005758","properties":[{"key":"GoTerm","value":"C:mitochondrial intermembrane space"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"FunFam","id":"1.10.287.1130:FF:000002","properties":[{"key":"EntryName","value":"cx9C motif-containing protein 4 isoform X2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.287.1130","properties":[{"key":"EntryName","value":"CytochromE C oxidase copper chaperone"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR027179","properties":[{"key":"EntryName","value":"CMC4"}]},{"database":"InterPro","id":"IPR009069","properties":[{"key":"EntryName","value":"Cys_alpha_HP_mot_SF"}]},{"database":"PANTHER","id":"PTHR15590","properties":[{"key":"EntryName","value":"CX9C MOTIF-CONTAINING PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15590:SF0","properties":[{"key":"EntryName","value":"CX9C MOTIF-CONTAINING PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08991","properties":[{"key":"EntryName","value":"CMC4"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47072","properties":[{"key":"EntryName","value":"Cysteine alpha-hairpin motif"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51808","properties":[{"key":"EntryName","value":"CHCH"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPQKDPCQKQACEIQKCLQANNYLESKCQAVIQELRKCCARYPKGRSLVCSGFEKEEEEKLAMKSGSK","length":68,"molWeight":7743,"crc64":"396E47FF1403A736","md5":"C60C0D7C659675BE32821F88C8DECC57"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DOMAIN":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Motif":2,"Disulfide bond":3},"uniParcId":"UPI00000236EA"}}