{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5VZ89","secondaryAccessions":["A2A3R1","A2A3R2","A2A3R3","A2A3R9","Q6AI48","Q6ZUB3","Q8NCY7","Q9H6N4","Q9NUT1","Q9NWA5","Q9NWT3","R4GN35","R4GNB2"],"uniProtkbId":"DEN4C_HUMAN","entryAudit":{"firstPublicDate":"2005-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2017-06-07","entryVersion":174,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DENN domain-containing protein 4C"}}},"genes":[{"geneName":{"value":"DENND4C"},"synonyms":[{"value":"C9orf55"},{"value":"C9orf55B"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20937701"}],"value":"Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Associates with SLC2A4/GLUT4 storage vesicles"}]},"subcellularLocations":[{"location":{"value":"Cytoplasmic vesicle membrane","id":"SL-0089"}},{"location":{"value":"Cell membrane","id":"SL-0039"}},{"location":{"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q5VZ89-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"3"},"isoformIds":["Q5VZ89-3"],"sequenceIds":["VSP_027384","VSP_027386"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q5VZ89-5"],"sequenceIds":["VSP_027382","VSP_027383"],"isoformSequenceStatus":"Described"},{"name":{"value":"2"},"isoformIds":["Q5VZ89-7"],"sequenceIds":["VSP_027379"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylated in response to insulin"}],"commentType":"PTM"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA91294.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA91478.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA92039.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB15221.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC86313.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"CAH10466.1","note":"Probable cloning artifact.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1909,"modifier":"EXACT"}},"description":"DENN domain-containing protein 4C","featureId":"PRO_0000089697"},{"type":"Domain","location":{"start":{"value":40,"modifier":"EXACT"},"end":{"value":199,"modifier":"EXACT"}},"description":"MABP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00831"}]},{"type":"Domain","location":{"start":{"value":191,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"uDENN","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00304"}]},{"type":"Domain","location":{"start":{"value":385,"modifier":"EXACT"},"end":{"value":521,"modifier":"EXACT"}},"description":"cDENN","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00304"}]},{"type":"Domain","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":641,"modifier":"EXACT"}},"description":"dDENN","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00304"}]},{"type":"Repeat","location":{"start":{"value":821,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"PPR"},{"type":"Region","location":{"start":{"value":1243,"modifier":"EXACT"},"end":{"value":1263,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1277,"modifier":"EXACT"},"end":{"value":1338,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1419,"modifier":"EXACT"},"end":{"value":1474,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1296,"modifier":"EXACT"},"end":{"value":1316,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1426,"modifier":"EXACT"},"end":{"value":1440,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1459,"modifier":"EXACT"},"end":{"value":1468,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":703,"modifier":"EXACT"},"end":{"value":703,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":737,"modifier":"EXACT"},"end":{"value":737,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":741,"modifier":"EXACT"},"end":{"value":741,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":965,"modifier":"EXACT"},"end":{"value":965,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":968,"modifier":"EXACT"},"end":{"value":968,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":973,"modifier":"EXACT"},"end":{"value":973,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":975,"modifier":"EXACT"},"end":{"value":975,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":989,"modifier":"EXACT"},"end":{"value":989,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":996,"modifier":"EXACT"},"end":{"value":996,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1003,"modifier":"EXACT"},"end":{"value":1003,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1046,"modifier":"EXACT"},"end":{"value":1046,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1061,"modifier":"EXACT"},"end":{"value":1061,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1099,"modifier":"EXACT"},"end":{"value":1099,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1126,"modifier":"EXACT"},"end":{"value":1126,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1184,"modifier":"EXACT"},"end":{"value":1184,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1225,"modifier":"EXACT"},"end":{"value":1225,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1244,"modifier":"EXACT"},"end":{"value":1244,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1252,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6H8H2"}]},{"type":"Modified residue","location":{"start":{"value":1278,"modifier":"EXACT"},"end":{"value":1278,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":1325,"modifier":"EXACT"},"end":{"value":1325,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1337,"modifier":"EXACT"},"end":{"value":1337,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1346,"modifier":"EXACT"},"end":{"value":1346,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1623,"modifier":"EXACT"},"end":{"value":1623,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1627,"modifier":"EXACT"},"end":{"value":1627,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":1629,"modifier":"EXACT"},"end":{"value":1629,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1640,"modifier":"EXACT"},"end":{"value":1640,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6H8H2"}]},{"type":"Modified residue","location":{"start":{"value":1799,"modifier":"EXACT"},"end":{"value":1799,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":911,"modifier":"EXACT"},"end":{"value":911,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_027379","alternativeSequence":{"originalSequence":"S","alternativeSequences":["SALQNVTGGSDGDTVSHGSVDSSNDANNGEHTVFVRDLIRLESIDNHSST"]}},{"type":"Alternative sequence","location":{"start":{"value":1606,"modifier":"EXACT"},"end":{"value":1623,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_027382","alternativeSequence":{"originalSequence":"SDEIKRASGDVQTMKISS","alternativeSequences":["RYQRVQRPLYVVINGVPL"]}},{"type":"Alternative sequence","location":{"start":{"value":1624,"modifier":"EXACT"},"end":{"value":1909,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_027383","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1844,"modifier":"EXACT"},"end":{"value":1845,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_027384","alternativeSequence":{"originalSequence":"SL","alternativeSequences":["GI"]}},{"type":"Alternative sequence","location":{"start":{"value":1846,"modifier":"EXACT"},"end":{"value":1909,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_027386","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1227,"modifier":"EXACT"},"end":{"value":1227,"modifier":"EXACT"}},"description":"in dbSNP:rs34267952","featureCrossReferences":[{"database":"dbSNP","id":"rs34267952"}],"featureId":"VAR_061640","alternativeSequence":{"originalSequence":"V","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":1266,"modifier":"EXACT"},"end":{"value":1266,"modifier":"EXACT"}},"description":"in dbSNP:rs17818730","featureCrossReferences":[{"database":"dbSNP","id":"rs17818730"}],"featureId":"VAR_022891","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":1343,"modifier":"EXACT"},"end":{"value":1343,"modifier":"EXACT"}},"description":"in dbSNP:rs6475322","featureCrossReferences":[{"database":"dbSNP","id":"rs6475322"}],"featureId":"VAR_022892","alternativeSequence":{"originalSequence":"N","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":683,"modifier":"EXACT"},"end":{"value":683,"modifier":"EXACT"}},"description":"in Ref. 3; BAC86313","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":1297,"modifier":"EXACT"},"end":{"value":1297,"modifier":"EXACT"}},"description":"in Ref. 3; BAA91294","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":1656,"modifier":"EXACT"},"end":{"value":1656,"modifier":"EXACT"}},"description":"in Ref. 3; BAA91478","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":1769,"modifier":"EXACT"},"end":{"value":1769,"modifier":"EXACT"}},"description":"in Ref. 3; BAA92039","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":1862,"modifier":"EXACT"},"end":{"value":1862,"modifier":"EXACT"}},"description":"in Ref. 4; CAH10466","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":1868,"modifier":"EXACT"},"end":{"value":1868,"modifier":"EXACT"}},"description":"in Ref. 4; CAH10466","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":1893,"modifier":"EXACT"},"end":{"value":1893,"modifier":"EXACT"}},"description":"in Ref. 4; CAD39177","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":1897,"modifier":"EXACT"},"end":{"value":1897,"modifier":"EXACT"}},"description":"in Ref. 4; CAH10466","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["A"]}},{"type":"Modified residue","location":{"start":{"value":953,"modifier":"EXACT"},"end":{"value":953,"modifier":"EXACT"},"sequence":"Q5VZ89-7"},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0344","category":"Molecular function","name":"Guanine-nucleotide releasing factor"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"15164053","citationType":"journal article","authors":["Humphray S.J.","Oliver K.","Hunt A.R.","Plumb R.W.","Loveland J.E.","Howe K.L.","Andrews T.D.","Searle S.","Hunt S.E.","Scott C.E.","Jones M.C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Ashwell R.I.S.","Babbage A.K.","Babbage S.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beasley H.","Beasley O.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Chen Y.","Clarke G.","Clark S.Y.","Clee C.M.","Clegg S.","Collier R.E.","Corby N.","Crosier M.","Cummings A.T.","Davies J.","Dhami P.","Dunn M.","Dutta I.","Dyer L.W.","Earthrowl M.E.","Faulkner L.","Fleming C.J.","Frankish A.","Frankland J.A.","French L.","Fricker D.G.","Garner P.","Garnett J.","Ghori J.","Gilbert J.G.R.","Glison C.","Grafham D.V.","Gribble S.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Guy J.","Hall R.E.","Hammond S.","Harley J.L.","Harrison E.S.I.","Hart E.A.","Heath P.D.","Henderson C.D.","Hopkins B.L.","Howard P.J.","Howden P.J.","Huckle E.","Johnson C.","Johnson D.","Joy A.A.","Kay M.","Keenan S.","Kershaw J.K.","Kimberley A.M.","King A.","Knights A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.","Lloyd D.M.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","McLaren S.","McLay K.E.","McMurray A.","Milne S.","Nickerson T.","Nisbett J.","Nordsiek G.","Pearce A.V.","Peck A.I.","Porter K.M.","Pandian R.","Pelan S.","Phillimore B.","Povey S.","Ramsey Y.","Rand V.","Scharfe M.","Sehra H.K.","Shownkeen R.","Sims S.K.","Skuce C.D.","Smith M.","Steward C.A.","Swarbreck D.","Sycamore N.","Tester J.","Thorpe A.","Tracey A.","Tromans A.","Thomas D.W.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Williams S.A.","Wilming L.","Wray P.W.","Young L.","Ashurst J.L.","Coulson A.","Blocker H.","Durbin R.M.","Sulston J.E.","Hubbard T.","Jackson M.J.","Bentley D.R.","Beck S.","Rogers J.","Dunham I."],"citationCrossReferences":[{"database":"PubMed","id":"15164053"},{"database":"DOI","id":"10.1038/nature02465"}],"title":"DNA sequence and analysis of human chromosome 9.","publicationDate":"2004","journal":"Nature","firstPage":"369","lastPage":"374","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 352-1909 (ISOFORM 1)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 966-1909 (ISOFORM 3)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1272-1909 (ISOFORM 5)"],"referenceComments":[{"value":"Embryo","type":"TISSUE"},{"value":"Hepatoma","type":"TISSUE"},{"value":"Placenta","type":"TISSUE"},{"value":"Signet-ring cell carcinoma","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 912-1909 (ISOFORM 1)"],"referenceComments":[{"value":"Fetal kidney","type":"TISSUE"},{"value":"Lymph node","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15144186","citationType":"journal article","authors":["Brill L.M.","Salomon A.R.","Ficarro S.B.","Mukherji M.","Stettler-Gill M.","Peters E.C."],"citationCrossReferences":[{"database":"PubMed","id":"15144186"},{"database":"DOI","id":"10.1021/ac035352d"}],"title":"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.","publicationDate":"2004","journal":"Anal. Chem.","firstPage":"2763","lastPage":"2772","volume":"76"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-741; SER-965; SER-968; SER-973; SER-989; SER-1003; SER-1046; SER-1099; SER-1126; SER-1225; SER-1244; SER-1278; SER-1325; SER-1623 AND SER-1627","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-973; SER-989; SER-1278 AND SER-1346","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"20937701","citationType":"journal article","authors":["Yoshimura S.","Gerondopoulos A.","Linford A.","Rigden D.J.","Barr F.A."],"citationCrossReferences":[{"database":"PubMed","id":"20937701"},{"database":"DOI","id":"10.1083/jcb.201008051"}],"title":"Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.","publicationDate":"2010","journal":"J. Cell Biol.","firstPage":"367","lastPage":"381","volume":"191"},"referencePositions":["FUNCTION AS GUANYL-NUCLEOTIDE EXCHANGE FACTOR"]},{"referenceNumber":11,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1225 AND SER-1623","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953 (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1184","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":14,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703; SER-737; SER-741; SER-968; SER-973; SER-989; SER-996; SER-1061; SER-1099; SER-1184; SER-1225; SER-1278; SER-1325; SER-1337; SER-1346; SER-1623 AND SER-1629","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-965; SER-968; SER-973; THR-975; SER-989; SER-1278 AND SER-1799","PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953 (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL161909","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL391834","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471071","properties":[{"key":"ProteinId","value":"EAW58645.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK000627","properties":[{"key":"ProteinId","value":"BAA91294.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK001046","properties":[{"key":"ProteinId","value":"BAA91478.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK002020","properties":[{"key":"ProteinId","value":"BAA92039.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK025705","properties":[{"key":"ProteinId","value":"BAB15221.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK125842","properties":[{"key":"ProteinId","value":"BAC86313.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL834521","properties":[{"key":"ProteinId","value":"CAD39177.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR627367","properties":[{"key":"ProteinId","value":"CAH10466.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS6491.3","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5VZ89-1"},{"database":"CCDS","id":"CCDS83349.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5VZ89-7"},{"database":"RefSeq","id":"NP_001317569.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001330640.2"}],"isoformId":"Q5VZ89-7"},{"database":"RefSeq","id":"NP_001372971.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001386042.1"}],"isoformId":"Q5VZ89-3"},{"database":"RefSeq","id":"NP_001372976.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001386047.1"}],"isoformId":"Q5VZ89-7"},{"database":"RefSeq","id":"NP_060395.5","properties":[{"key":"NucleotideSequenceId","value":"NM_017925.7"}],"isoformId":"Q5VZ89-1"},{"database":"RefSeq","id":"XP_047279540.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423584.1"}],"isoformId":"Q5VZ89-1"},{"database":"RefSeq","id":"XP_054219245.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054363270.1"}],"isoformId":"Q5VZ89-1"},{"database":"PDB","id":"9O9I","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.35 A"},{"key":"Chains","value":"B=1189-1206"}]},{"database":"PDBsum","id":"9O9I","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120799","properties":[{"key":"Interactions","value":"149"}]},{"database":"FunCoup","id":"Q5VZ89","properties":[{"key":"Number of interactors","value":"3417"}]},{"database":"IntAct","id":"Q5VZ89","properties":[{"key":"Interactions","value":"50"}]},{"database":"MINT","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000473469","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q5VZ89","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DENND4C","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"158937337","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000473469","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"65680","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5VZ89-1"},{"database":"ProteomicsDB","id":"65682","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5VZ89-3"},{"database":"ProteomicsDB","id":"65684","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5VZ89-5"},{"database":"Pumba","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"10280","properties":[{"key":"antibodies","value":"85 antibodies from 18 providers"}]},{"database":"Ensembl","id":"ENST00000434457.7","properties":[{"key":"ProteinId","value":"ENSP00000473469.1"},{"key":"GeneId","value":"ENSG00000137145.22"}],"isoformId":"Q5VZ89-7"},{"database":"Ensembl","id":"ENST00000602925.5","properties":[{"key":"ProteinId","value":"ENSP00000473565.1"},{"key":"GeneId","value":"ENSG00000137145.22"}],"isoformId":"Q5VZ89-1"},{"database":"GeneID","id":"55667","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:55667","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000434457.7","properties":[{"key":"ProteinId","value":"ENSP00000473469.1"},{"key":"RefSeqNucleotideId","value":"NM_001330640.2"},{"key":"RefSeqProteinId","value":"NP_001317569.1"}],"isoformId":"Q5VZ89-7"},{"database":"UCSC","id":"uc031tcw.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:26079","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134939495","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55667","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"55667","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DENND4C","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26079","properties":[{"key":"GeneName","value":"DENND4C"}]},{"database":"HPA","id":"ENSG00000137145","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000137145","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000137145","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2127","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158215","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ICYRVMM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"75250at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q5VZ89","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8876198","properties":[{"key":"PathwayName","value":"RAB GEFs exchange GTP for GDP on RABs"}]},{"database":"SignaLink","id":"Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000137145","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"55667","properties":[{"key":"hits","value":"15 hits in 1153 CRISPR screens"}]},{"database":"ChiTaRS","id":"DENND4C","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"55667","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q5VZ89","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q5VZ89","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 9"}]},{"database":"RNAct","id":"Q5VZ89","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000137145","properties":[{"key":"ExpressionPatterns","value":"Expressed in jejunal mucosa and 203 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5VZ89","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030659","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0032593","properties":[{"key":"GoTerm","value":"C:insulin-responsive compartment"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005085","properties":[{"key":"GoTerm","value":"F:guanyl-nucleotide exchange factor activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20937701"}]},{"database":"GO","id":"GO:0032869","properties":[{"key":"GoTerm","value":"P:cellular response to insulin stimulus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0072659","properties":[{"key":"GoTerm","value":"P:protein localization to plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032483","properties":[{"key":"GoTerm","value":"P:regulation of Rab protein signal transduction"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"FunFam","id":"1.25.40.10:FF:000042","properties":[{"key":"EntryName","value":"C-myc promoter-binding protein isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.100.10.50:FF:000001","properties":[{"key":"EntryName","value":"DENN domain containing 4C"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.100.10.50","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11500","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.25.40.10","properties":[{"key":"EntryName","value":"Tetratricopeptide repeat domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001194","properties":[{"key":"EntryName","value":"cDENN_dom"}]},{"database":"InterPro","id":"IPR005112","properties":[{"key":"EntryName","value":"dDENN_dom"}]},{"database":"InterPro","id":"IPR043153","properties":[{"key":"EntryName","value":"DENN_C"}]},{"database":"InterPro","id":"IPR051696","properties":[{"key":"EntryName","value":"DENN_Domain_GEFs"}]},{"database":"InterPro","id":"IPR023341","properties":[{"key":"EntryName","value":"MABP"}]},{"database":"InterPro","id":"IPR011990","properties":[{"key":"EntryName","value":"TPR-like_helical_dom_sf"}]},{"database":"InterPro","id":"IPR037516","properties":[{"key":"EntryName","value":"Tripartite_DENN"}]},{"database":"InterPro","id":"IPR005113","properties":[{"key":"EntryName","value":"uDENN_dom"}]},{"database":"PANTHER","id":"PTHR12296","properties":[{"key":"EntryName","value":"DENN DOMAIN-CONTAINING PROTEIN 4"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12296:SF17","properties":[{"key":"EntryName","value":"DENN DOMAIN-CONTAINING PROTEIN 4C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03455","properties":[{"key":"EntryName","value":"dDENN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02141","properties":[{"key":"EntryName","value":"DENN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10240","properties":[{"key":"EntryName","value":"MABP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03456","properties":[{"key":"EntryName","value":"uDENN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00801","properties":[{"key":"EntryName","value":"dDENN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00799","properties":[{"key":"EntryName","value":"DENN"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00800","properties":[{"key":"EntryName","value":"uDENN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50211","properties":[{"key":"EntryName","value":"DENN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51498","properties":[{"key":"EntryName","value":"MABP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPITDIAIIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYKRGRDKPPLTDIGVLYEGKERLIPGCEVILATPYGRCANVNNSSTTSQRIFITYRRAPPVRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESDVPLFCLPMGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWAKCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKKTVQRSQVSSISGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPVEDAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALTCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEEETNRDYSFPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQMKPGMKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGIAYNSLSSEILERLQKIDAPPSASVEWCRKCFGAPLI","length":1909,"molWeight":212711,"crc64":"3AB522323299D990","md5":"676677074D8D94ABF52866BFA75C3B01"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"PTM":1,"SEQUENCE CAUTION":6},"countByFeatureType":{"Chain":1,"Domain":4,"Repeat":1,"Region":3,"Compositional bias":3,"Modified residue":28,"Alternative sequence":5,"Natural variant":3,"Sequence conflict":8},"uniParcId":"UPI0000EE421F"}}