{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5VVY1","secondaryAccessions":["B2RXI0"],"uniProtkbId":"NTM1B_HUMAN","entryAudit":{"firstPublicDate":"2007-01-09","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-11-24","entryVersion":137,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"N-terminal Xaa-Pro-Lys N-methyltransferase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24090352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"}],"value":"2.1.1.299"}]},"alternativeNames":[{"fullName":{"value":"Alpha N-terminal protein methyltransferase 1B"}},{"fullName":{"value":"Methyltransferase-like protein 11B"}},{"fullName":{"value":"X-Pro-Lys N-terminal protein methyltransferase 1B"},"shortNames":[{"value":"NTM1B"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:31932"}],"value":"NTMT2"},"synonyms":[{"value":"C1orf184"},{"value":"METTL11B"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24090352"}],"value":"NRMT2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24090352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"}],"value":"Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120). Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120). May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54096"},{"database":"Rhea","id":"RHEA-COMP:13785"},{"database":"Rhea","id":"RHEA-COMP:13786"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:138057"},{"database":"ChEBI","id":"CHEBI:138058"}],"ecNumber":"2.1.1.299","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24090352"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54097"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24090352"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54100"},{"database":"Rhea","id":"RHEA-COMP:13787"},{"database":"Rhea","id":"RHEA-COMP:13788"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:138059"},{"database":"ChEBI","id":"CHEBI:138060"}],"ecNumber":"2.1.1.299","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24090352"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54101"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24090352"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54104"},{"database":"Rhea","id":"RHEA-COMP:13789"},{"database":"Rhea","id":"RHEA-COMP:13790"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57856"},{"database":"ChEBI","id":"CHEBI:59789"},{"database":"ChEBI","id":"CHEBI:138061"},{"database":"ChEBI","id":"CHEBI:138062"}],"ecNumber":"2.1.1.299","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24090352"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:54105"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24090352"}]}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24090352"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the methyltransferase superfamily. NTM1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":283,"modifier":"EXACT"}},"description":"N-terminal Xaa-Pro-Lys N-methyltransferase 2","featureId":"PRO_0000271077"},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UBB"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UBB"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":146,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UBB"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UBB"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Binding site","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:59789"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UBB"}],"ligand":{"name":"S-adenosyl-L-methionine","id":"ChEBI:CHEBI:59789"}},{"type":"Natural variant","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":72,"modifier":"EXACT"}},"description":"in dbSNP:rs12073565","featureCrossReferences":[{"database":"dbSNP","id":"rs12073565"}],"featureId":"VAR_060621","alternativeSequence":{"originalSequence":"A","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"in dbSNP:rs6427235","featureCrossReferences":[{"database":"dbSNP","id":"rs6427235"}],"featureId":"VAR_029859","alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":247,"modifier":"EXACT"},"end":{"value":247,"modifier":"EXACT"}},"description":"in dbSNP:rs12735494","featureCrossReferences":[{"database":"dbSNP","id":"rs12735494"}],"featureId":"VAR_060622","alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Increases methylation activity. Higher affinity for mono-methylated peptide than wild-type.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30417120"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["G"]}},{"type":"Turn","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":76,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Turn","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":91,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Turn","location":{"start":{"value":106,"modifier":"EXACT"},"end":{"value":108,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":111,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Turn","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":131,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Turn","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":184,"modifier":"EXACT"},"end":{"value":191,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":195,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":232,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Turn","location":{"start":{"value":233,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":237,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Helix","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]},{"type":"Beta strand","location":{"start":{"value":272,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"6DUB"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0489","category":"Molecular function","name":"Methyltransferase"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0949","category":"Ligand","name":"S-adenosyl-L-methionine"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":3,"citation":{"id":"24090352","citationType":"journal article","authors":["Petkowski J.J.","Bonsignore L.A.","Tooley J.G.","Wilkey D.W.","Merchant M.L.","Macara I.G.","Schaner Tooley C.E."],"citationCrossReferences":[{"database":"PubMed","id":"24090352"},{"database":"DOI","id":"10.1042/bj20131163"}],"title":"NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.","publicationDate":"2013","journal":"Biochem. J.","firstPage":"453","lastPage":"462","volume":"456"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","SUBCELLULAR LOCATION"]},{"referenceNumber":4,"citation":{"id":"30417120","citationType":"journal article","authors":["Dong C.","Dong G.","Li L.","Zhu L.","Tempel W.","Liu Y.","Huang R.","Min J."],"citationCrossReferences":[{"database":"PubMed","id":"30417120"},{"database":"DOI","id":"10.1038/s42003-018-0196-2"}],"title":"An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2.","publicationDate":"2018","journal":"Commun. Biol.","firstPage":"183","lastPage":"183","volume":"1"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) OF 58-278 IN COMPLEX WITH PEPTIDE SUBSTRATE AND S-ADENOSYL-L-METHIONINE","MUTAGENESIS OF ASN-89","FUNCTION","CATALYTIC ACTIVITY"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"5UBB"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6DUB"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL445203","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC157860","properties":[{"key":"ProteinId","value":"AAI57861.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC171858","properties":[{"key":"ProteinId","value":"AAI71858.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS44275.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001129579.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001136107.2"}]},{"database":"PDB","id":"5UBB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=58-278"}]},{"database":"PDB","id":"6DUB","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.20 A"},{"key":"Chains","value":"A/B=58-278"}]},{"database":"PDB","id":"6KDR","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.11 A"},{"key":"Chains","value":"A/B=61-283"}]},{"database":"PDB","id":"6KDS","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"1.84 A"},{"key":"Chains","value":"A=61-283"}]},{"database":"PDBsum","id":"5UBB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6DUB","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KDR","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"6KDS","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q5VVY1","properties":[{"key":"Number of interactors","value":"501"}]},{"database":"STRING","id":"9606.ENSP00000408058","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4630834","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q5VVY1","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"METTL11B","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"269849617","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000408058","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"34370","properties":[{"key":"antibodies","value":"67 antibodies from 15 providers"}]},{"database":"DNASU","id":"149281","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000439373.3","properties":[{"key":"ProteinId","value":"ENSP00000408058.3"},{"key":"GeneId","value":"ENSG00000203740.5"}]},{"database":"GeneID","id":"149281","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:149281","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000439373.3","properties":[{"key":"ProteinId","value":"ENSP00000408058.3"},{"key":"RefSeqNucleotideId","value":"NM_001136107.2"},{"key":"RefSeqProteinId","value":"NP_001129579.1"}]},{"database":"UCSC","id":"uc009wvv.2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:31932","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"149281","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"149281","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"NTMT2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:31932","properties":[{"key":"GeneName","value":"NTMT2"}]},{"database":"HPA","id":"ENSG00000203740","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (heart)"}]},{"database":"OpenTargets","id":"ENSG00000203740","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000203740","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3178","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008371","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_055356_3_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"ETYYCFN","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"1864at9604","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q5VVY1","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.1.1.299","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"149281","properties":[{"key":"hits","value":"6 hits in 1145 CRISPR screens"}]},{"database":"ChiTaRS","id":"METTL11B","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"149281","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q5VVY1","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q5VVY1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q5VVY1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000203740","properties":[{"key":"ExpressionPatterns","value":"Expressed in male germ line stem cell (sensu Vertebrata) in testis and 19 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24090352"}]},{"database":"GO","id":"GO:0071885","properties":[{"key":"GoTerm","value":"F:N-terminal protein N-methyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24090352"}]},{"database":"CDD","id":"cd02440","properties":[{"key":"EntryName","value":"AdoMet_MTases"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.150:FF:000025","properties":[{"key":"EntryName","value":"N-terminal Xaa-Pro-Lys N-methyltransferase 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.150","properties":[{"key":"EntryName","value":"Vaccinia Virus protein VP39"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008576","properties":[{"key":"EntryName","value":"MeTrfase_NTM1"}]},{"database":"InterPro","id":"IPR029063","properties":[{"key":"EntryName","value":"SAM-dependent_MTases_sf"}]},{"database":"PANTHER","id":"PTHR12753","properties":[{"key":"EntryName","value":"AD-003 - RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12753:SF2","properties":[{"key":"EntryName","value":"N-TERMINAL XAA-PRO-LYS N-METHYLTRANSFERASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05891","properties":[{"key":"EntryName","value":"Methyltransf_PK"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF53335","properties":[{"key":"EntryName","value":"S-adenosyl-L-methionine-dependent methyltransferases"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAHRGAHFAFRSRWQKTDDELCRHSMSFILHKAIRNDFFQSYLYLLEKIPLVKLYALTSQVINGEMQFYARAKLFYQEVPATEEGMMGNFIELSSPDIQASQKFLRKFVGGPGRAGTDCALDCGSGIGRVSKHVLLPVFNSVELVDMMESFLLEAQNYLQVKGDKVESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSRCRDGLKENGIIILKDNVAREGCILDLSDSSVTRDMDILRSLIRKSGLVVLGQEKQDGFPEQCIPVWMFALHSDRHS","length":283,"molWeight":32400,"crc64":"F1FEAB7391A229C4","md5":"8728BCD453315A45277A5975644F83B5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Binding site":6,"Natural variant":3,"Mutagenesis":1,"Turn":6,"Helix":11,"Beta strand":9},"uniParcId":"UPI0000418EF1"}}