{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5VU43","secondaryAccessions":["A0A0A0MRM0","A0A0C4DFQ0","A2RU15","E9PL24","O75042","O75065","Q2YDC1","Q5VU42","Q5VU44","Q5VU45","Q5VU46","Q5VU47","Q5VU48","Q5VU49","Q68DU2","Q6AZ93","Q6PK88","Q86T40","Q86TB2","Q8N3W0","Q8TAY9","Q9HCP2","Q9HCP3","Q9HCP4","Q9HCP5"],"uniProtkbId":"MYOME_HUMAN","entryAudit":{"firstPublicDate":"2007-10-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2018-03-28","entryVersion":180,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Myomegalin"}},"alternativeNames":[{"fullName":{"value":"Cardiomyopathy-associated protein 2"}},{"fullName":{"value":"Phosphodiesterase 4D-interacting protein"}}]},"genes":[{"geneName":{"value":"PDE4DIP"},"synonyms":[{"value":"CMYA2"},{"value":"KIAA0454"},{"value":"KIAA0477"},{"value":"MMGL"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WUJ3"}],"value":"Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25217626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27666745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28814570"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29162697"}],"value":"Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697)"}],"commentType":"FUNCTION","molecule":"Isoform 13"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9WUJ3"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25217626"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27666745"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28814570"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29162697"}],"value":"Interacts with PDE4D (By similarity). Isoform 13 interacts with MAPRE1 and MAPRE3 (PubMed:25217626, PubMed:28814570, PubMed:29162697). Isoform 13 forms a pericentrosomal complex with AKAP9, CDK5RAP2 and EB1/MAPRE1; within this complex, may mediate MAPRE1-binding to CDK5RAP2 (PubMed:29162697). Interaction of isoform 13 with AKAP9 stabilizes both proteins (PubMed:25217626, PubMed:27666745). Isoform 13 interacts (via N-terminus) with CAMSAP2; this interaction is much stronger in the presence of AKAP9 (PubMed:27666745). In complex with AKAP9, Isoform 13 recruits CAMSAP2 to the Golgi apparatus (PubMed:27666745, PubMed:28814570). Isoform 13 interacts with unglycosylated LGALS3BP; this interaction may connect the pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:25217626, PubMed:29162697)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q8WTP8","geneName":"AEN","intActId":"EBI-8637627"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q9NX04","geneName":"AIRIM","intActId":"EBI-8643161"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q13895","geneName":"BYSL","intActId":"EBI-358049"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q9NVL8","geneName":"CCDC198","intActId":"EBI-10238351"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q9NX63","geneName":"CHCHD3","intActId":"EBI-743375"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q9NRI5","geneName":"DISC1","intActId":"EBI-529989"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q3B820","geneName":"FAM161A","intActId":"EBI-719941"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q0D2H9","geneName":"GOLGA8DP","intActId":"EBI-10181276"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q08AF8","geneName":"GOLGA8G","intActId":"EBI-10181260"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q96CS2","geneName":"HAUS1","intActId":"EBI-2514791"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q16891","geneName":"IMMT","intActId":"EBI-473801"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q6P597","geneName":"KLC3","intActId":"EBI-1643885"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q96BZ8","geneName":"LENG1","intActId":"EBI-726510"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"P61968","geneName":"LMO4","intActId":"EBI-2798728"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q15691","geneName":"MAPRE1","intActId":"EBI-1004115"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"A9UHW6","geneName":"MIF4GD","intActId":"EBI-373498"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q5JR59","geneName":"MTUS2","intActId":"EBI-742948"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"P41227","geneName":"NAA10","intActId":"EBI-747693"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q6NYC8","geneName":"PPP1R18","intActId":"EBI-2557469"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q8WWY3","geneName":"PRPF31","intActId":"EBI-1567797"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q14D33","geneName":"RTP5","intActId":"EBI-10217913"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"Q9BWG6","geneName":"SCNM1","intActId":"EBI-748391"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5VU43","intActId":"EBI-1105124"},"interactantTwo":{"uniProtKBAccession":"O00560","geneName":"SDCBP","intActId":"EB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