{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5SW28","secondaryAccessions":["Q3TU01","Q3UDZ2","Q8C215","Q8CGQ7"],"uniProtkbId":"PI3R5_MOUSE","entryAudit":{"firstPublicDate":"2005-12-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-12-21","entryVersion":134,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Phosphoinositide 3-kinase regulatory subunit 5"},"shortNames":[{"value":"PI3-kinase regulatory subunit 5"}]},"alternativeNames":[{"fullName":{"value":"PI3-kinase p101 subunit"}},{"fullName":{"value":"Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit"},"shortNames":[{"value":"PtdIns-3-kinase regulatory subunit"}]},{"fullName":{"value":"PtdIns-3-kinase p101"}},{"fullName":{"value":"p101-PI3K"}}]},"genes":[{"geneName":{"value":"Pik3r5"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Greatly activated by G gamma proteins"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O02696"}],"value":"Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O02696"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O02696"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O02696"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O02696"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The heterodimerization region allows the binding to the catalytic subunit"}],"commentType":"DOMAIN"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":871,"modifier":"EXACT"}},"description":"Phosphoinositide 3-kinase regulatory subunit 5","featureId":"PRO_0000058422"},{"type":"Region","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"Heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":413,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":646,"modifier":"EXACT"},"end":{"value":746,"modifier":"EXACT"}},"description":"Interaction with beta-gamma G protein dimers","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O02696"}]},{"type":"Modified residue","location":{"start":{"value":451,"modifier":"EXACT"},"end":{"value":451,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":500,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8WYR1"}]},{"type":"Sequence conflict","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"in Ref. 2; BAE29119","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":269,"modifier":"EXACT"}},"description":"in Ref. 2; BAC40901","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":369,"modifier":"EXACT"},"end":{"value":369,"modifier":"EXACT"}},"description":"in Ref. 1; AAN84787","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"in Ref. 1; AAN84787","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":647,"modifier":"EXACT"},"end":{"value":647,"modifier":"EXACT"}},"description":"in Ref. 1; AAN84787","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":651,"modifier":"EXACT"},"end":{"value":651,"modifier":"EXACT"}},"description":"in Ref. 1; AAN84787","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":796,"modifier":"EXACT"},"end":{"value":796,"modifier":"EXACT"}},"description":"in Ref. 2; BAE29119","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1HLGVO9ILOG60","citationType":"submission","authors":["Procko E.","McColl S.R."],"title":"Cloning of a murine ortholog of a PI3-kinase gamma regulatory protein.","publicationDate":"SEP-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"BALB/cJ","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY156924","properties":[{"key":"ProteinId","value":"AAN84787.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK089483","properties":[{"key":"ProteinId","value":"BAC40901.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK149847","properties":[{"key":"ProteinId","value":"BAE29119.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK161050","properties":[{"key":"ProteinId","value":"BAE36171.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL606831","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS24865.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_796294.2","properties":[{"key":"NucleotideSequenceId","value":"NM_177320.2"}]},{"database":"RefSeq","id":"XP_006533611.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006533548.3"}]},{"database":"AlphaFoldDB","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"CORUM","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q5SW28","properties":[{"key":"Number of interactors","value":"754"}]},{"database":"IntAct","id":"Q5SW28","properties":[{"key":"Interactions","value":"2"}]},{"database":"STRING","id":"10090.ENSMUSP00000021283","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000021283","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"289417","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"24754","properties":[{"key":"antibodies","value":"454 antibodies from 32 providers"}]},{"database":"DNASU","id":"320207","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000021283.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000021283.8"},{"key":"GeneId","value":"ENSMUSG00000020901.14"}]},{"database":"GeneID","id":"320207","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:320207","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007jno.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2443588","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23533","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2443588","properties":[{"key":"GeneName","value":"Pik3r5"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000020901","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QV4A","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063753","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_337590_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VLCQHSL","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9932678at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-114604","properties":[{"key":"PathwayName","value":"GPVI-mediated activation cascade"}]},{"database":"Reactome","id":"R-MMU-1257604","properties":[{"key":"PathwayName","value":"PIP3 activates AKT signaling"}]},{"database":"Reactome","id":"R-MMU-1660499","properties":[{"key":"PathwayName","value":"Synthesis of PIPs at the plasma membrane"}]},{"database":"Reactome","id":"R-MMU-389357","properties":[{"key":"PathwayName","value":"CD28 dependent PI3K/Akt signaling"}]},{"database":"Reactome","id":"R-MMU-392451","properties":[{"key":"PathwayName","value":"G beta:gamma signalling through PI3Kgamma"}]},{"database":"Reactome","id":"R-MMU-6811558","properties":[{"key":"PathwayName","value":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"}]},{"database":"Reactome","id":"R-MMU-9027276","properties":[{"key":"PathwayName","value":"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"}]},{"database":"Reactome","id":"R-MMU-9927354","properties":[{"key":"PathwayName","value":"Co-stimulation by ICOS"}]},{"database":"BioGRID-ORCS","id":"320207","properties":[{"key":"hits","value":"7 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q5SW28","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q5SW28","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000020901","properties":[{"key":"ExpressionPatterns","value":"Expressed in granulocyte and 80 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5SW28","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0034451","properties":[{"key":"GoTerm","value":"C:centriolar satellite"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005942","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005943","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex, class IA"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005944","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex, class IB"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046935","properties":[{"key":"GoTerm","value":"F:1-phosphatidylinositol-3-kinase regulator activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031683","properties":[{"key":"GoTerm","value":"F:G-protein beta/gamma-subunit complex binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043491","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046488","properties":[{"key":"GoTerm","value":"P:phosphatidylinositol metabolic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043406","properties":[{"key":"GoTerm","value":"P:positive regulation of MAP kinase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0051897","properties":[{"key":"GoTerm","value":"P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR019522","properties":[{"key":"EntryName","value":"PIK3R5/6"}]},{"database":"PANTHER","id":"PTHR15593","properties":[{"key":"EntryName","value":"PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15593:SF2","properties":[{"key":"EntryName","value":"PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10486","properties":[{"key":"EntryName","value":"PI3K_1B_p101"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MQPAATTCTEDRIQHALERCLHGLSLGRRSAPWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTQEVQEKGTYDLLAPLALLFYSTVLCTPHFPPDSDLLLKAASTYHCFLTWPVPYCSICREMLTFIDAELKAPGISYQRLVRAEQGLPVRSHRSSTVTVLLLNPVEVQAEFLAVADKLSTPGQSPHGTYTTLLLHAFQATFGAHCDLPKLHRKLQSKTIEELEDIFTETTEAQELASGIGDVAEAREWLRTKLQAVGEKAGFPGILDTASPGKLHTIPIPVARCYTYSWNQDSFDILQEVLLKEQELLQPGILGDDEEEEEEDLEMDRHCAERDSLLSTSSLVSHDSTLLLTSSQASEPVLSRQMLTTFVSGLSDGMDSGYVEDSEENSEWPQKPGSQKRQGHRRPGQKFNRFYKLLKSTSQLVLRRDSRSLESSVDPTLPLRRAGSLCSPLDCPAQLPSRAQRSRSLPQAKLTTQLPRWLLAPPSHHQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSKLRRLETSHPILTRFFKLQFFYVPVKRSHGTSPSACPSSLSQASPLPADSLKYPSPTDLGMAPWEDSTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKADSRPLEGSATQLPILADMLLYYCRFAARPVLLQVYQTELTFVTGEKTTEIFIQSLELGHSATTRAIKASGRGRKRLGIDDDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLSKACQKPEELDSSMEALTLTLTEVVKRQNPKSKKGFNQISTSYIKVDKVQIIGSSSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSSLPPERSFSQPAETGSDLCSLLCLPIMTFSGALP","length":871,"molWeight":96954,"crc64":"1D0F36A3D4042D62","md5":"DB8576E31216A46D3B3D4EF312E8A0B3"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ACTIVITY REGULATION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1},"countByFeatureType":{"Chain":1,"Region":3,"Modified residue":3,"Sequence conflict":7},"uniParcId":"UPI0000192B93"}}