{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5SNT2","secondaryAccessions":["B9EH90","Q5SNT3"],"uniProtkbId":"TM201_HUMAN","entryAudit":{"firstPublicDate":"2008-02-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-12-21","entryVersion":147,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transmembrane protein 201"}},"alternativeNames":[{"fullName":{"value":"Spindle-associated membrane protein 1"}}]},"genes":[{"geneName":{"value":"TMEM201"},"synonyms":[{"value":"NET5"},{"value":"SAMP1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2A8U2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35311970"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27541860"}],"value":"Critical regulator of angiogenesis and endothelial cell (EC) migration (PubMed:35311970). Promotes the migration of endothelial cells, which is essential for angiogenesis (PubMed:35311970). Interacts with the linker of nucleoskeleton and cytoskeleton (LINC) complex, which plays a vital role in connecting the cell's cytoskeleton to the nuclear envelope (PubMed:35311970). This interaction is essential for maintaining cellular structure and facilitating the movement of endothelial cells, which is critical for proper vascular development (PubMed:35311970). Involved in nuclear movement during fibroblast polarization and migration (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494128"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}],"value":"May define a distinct membrane domain in the vicinity of the mitotic spindle (PubMed:19494128). Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina (PubMed:21610090)"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35311970"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"27541860"}],"value":"Interacts with SUN2 and LMNA (PubMed:35311970). May bind to Ran GTPase; has a greater affinity for Ran-GTP over Ran-GDP"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}],"value":"Interacts with EMD"}],"commentType":"SUBUNIT","molecule":"Isoform 2"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q6ZS10","geneName":"CLEC17A","intActId":"EBI-11977093"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q7Z7G2","geneName":"CPLX4","intActId":"EBI-18013275"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"P00387","geneName":"CYB5R3","intActId":"EBI-1046040"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q96KC8","geneName":"DNAJC1","intActId":"EBI-296550"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"P50402","geneName":"EMD","intActId":"EBI-489887"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q969F0","geneName":"FATE1","intActId":"EBI-743099"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"A2A2Y4","geneName":"FRMD3","intActId":"EBI-6911547"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q8TDT2","geneName":"GPR152","intActId":"EBI-13345167"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q92806","geneName":"KCNJ9","intActId":"EBI-12822837"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q8TAF8","geneName":"LHFPL5","intActId":"EBI-2820517"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q8N386","geneName":"LRRC25","intActId":"EBI-11304917"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q9GZY8-5","geneName":"MFF","intActId":"EBI-11956541"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q9UPX6","geneName":"MINAR1","intActId":"EBI-11977115"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q8N183","geneName":"NDUFAF2","intActId":"EBI-2682365"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"P54829","geneName":"PTPN5","intActId":"EBI-1220572"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q9BXS9-3","geneName":"SLC26A6","intActId":"EBI-12814225"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q96Q45-2","geneName":"TMEM237","intActId":"EBI-10982110"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q53FP2","geneName":"TMEM35A","intActId":"EBI-11722971"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q5SNT2-2","intActId":"EBI-11994282"},"interactantTwo":{"uniProtKBAccession":"Q9Y320","geneName":"TMX2","intActId":"EBI-6447886"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35311970"}],"value":"Nucleus inner membrane","id":"SL-0179"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 2","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494128"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}],"value":"The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494128"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}],"value":"Nucleus inner membrane","id":"SL-0179"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494128"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19494128"}],"value":"Cytoplasm, cytoskeleton, spindle pole","id":"SL-0448"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q5SNT2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"SAMP1"}],"isoformIds":["Q5SNT2-2"],"sequenceIds":["VSP_030915","VSP_030916"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM201 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"Transmembrane protein 201","featureId":"PRO_0000317198"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}]},{"type":"Transmembrane","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Perinuclear space","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":298,"modifier":"EXACT"},"end":{"value":318,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":319,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":356,"modifier":"EXACT"}},"description":"Perinuclear space","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":374,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":375,"modifier":"EXACT"},"end":{"value":644,"modifier":"EXACT"}},"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"19494128"}]},{"type":"Transmembrane","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":665,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"Perinuclear space","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Region","location":{"start":{"value":502,"modifier":"EXACT"},"end":{"value":581,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":508,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":441,"modifier":"EXACT"},"end":{"value":441,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":444,"modifier":"EXACT"},"end":{"value":444,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":454,"modifier":"EXACT"},"end":{"value":454,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":466,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":480,"modifier":"EXACT"},"end":{"value":480,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":529,"modifier":"EXACT"},"end":{"value":529,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18691976"}]},{"type":"Alternative sequence","location":{"start":{"value":388,"modifier":"EXACT"},"end":{"value":392,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_030915","alternativeSequence":{"originalSequence":"FFPGD","alternativeSequences":["SEKQP"]}},{"type":"Alternative sequence","location":{"start":{"value":393,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_030916","alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"},"sequence":"Q5SNT2-2"},"description":"Impairs organization of the nuclear envelope; abolishes its localization to the nuclear envelope; impairs localization of SUN1 and EMD to the nuclear envelope.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":121,"modifier":"EXACT"},"sequence":"Q5SNT2-2"},"description":"Abolishes localization to the nuclear envelopee; abolishes its localization to the nuclear envelope; impairs localization of SUN1 and EMD to the nuclear envelope.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21610090"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"18691976","citationType":"journal article","authors":["Daub H.","Olsen J.V.","Bairlein M.","Gnad F.","Oppermann F.S.","Korner R.","Greff Z.","Keri G.","Stemmann O.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"18691976"},{"database":"DOI","id":"10.1016/j.molcel.2008.07.007"}],"title":"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.","publicationDate":"2008","journal":"Mol. Cell","firstPage":"438","lastPage":"448","volume":"31"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454 AND SER-529","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"19494128","citationType":"journal article","authors":["Buch C.","Lindberg R.","Figueroa R.","Gudise S.","Onischenko E.","Hallberg E."],"citationCrossReferences":[{"database":"PubMed","id":"19494128"},{"database":"DOI","id":"10.1242/jcs.047373"}],"title":"An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells.","publicationDate":"2009","journal":"J. Cell Sci.","firstPage":"2100","lastPage":"2107","volume":"122"},"referencePositions":["FUNCTION (ISOFORM 2)","SUBCELLULAR LOCATION (ISOFORM 2)"]},{"referenceNumber":6,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"21610090","citationType":"journal article","authors":["Gudise S.","Figueroa R.A.","Lindberg R.","Larsson V.","Hallberg E."],"citationCrossReferences":[{"database":"PubMed","id":"21610090"},{"database":"DOI","id":"10.1242/jcs.078923"}],"title":"Samp1 is functionally associated with the LINC complex and A-type lamina networks.","publicationDate":"2011","journal":"J. Cell Sci.","firstPage":"2077","lastPage":"2085","volume":"124"},"referencePositions":["SUBCELLULAR LOCATION (ISOFORM 2)","TOPOLOGY (ISOFORM 2)","MUTAGENESIS OF CYS-48 AND CYS-121 (ISOFORM 2)","INTERACTION WITH EMD (ISOFORM 2)","FUNCTION (ISOFORM 2)"]},{"referenceNumber":8,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-441; SER-444; SER-450; SER-454; SER-466; SER-477 AND SER-480","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"27541860","citationType":"journal article","authors":["Vijayaraghavan B.","Jafferali M.H.","Figueroa R.A.","Hallberg E."],"citationCrossReferences":[{"database":"PubMed","id":"27541860"},{"database":"DOI","id":"10.1080/19491034.2016.1220465"}],"title":"Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane.","publicationDate":"2016","journal":"Nucleus","firstPage":"415","lastPage":"423","volume":"7"},"referencePositions":["FUNCTION","SUBUNIT"]},{"referenceNumber":11,"citation":{"id":"35311970","citationType":"journal article","authors":["Zhang Y.","Kong Y.","Guo H.","Liu Y.","Zang Y.","Li J."],"citationCrossReferences":[{"database":"PubMed","id":"35311970"},{"database":"DOI","id":"10.1093/jmcb/mjac017"}],"title":"Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex.","publicationDate":"2022","journal":"J. Mol. Cell Biol.","firstPage":"0","lastPage":"0","volume":"14"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH SUN2 AND LMNA"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL954705","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC121187","properties":[{"key":"ProteinId","value":"AAI21188.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC137291","properties":[{"key":"ProteinId","value":"AAI37292.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS30579.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5SNT2-2"},{"database":"CCDS","id":"CCDS44055.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5SNT2-1"},{"database":"RefSeq","id":"NP_001010866.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001010866.4"}],"isoformId":"Q5SNT2-2"},{"database":"RefSeq","id":"NP_001124396.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001130924.3"}],"isoformId":"Q5SNT2-1"},{"database":"RefSeq","id":"XP_011539212.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011540910.3"}],"isoformId":"Q5SNT2-2"},{"database":"RefSeq","id":"XP_054190874.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054334899.1"}],"isoformId":"Q5SNT2-2"},{"database":"AlphaFoldDB","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"128285","properties":[{"key":"Interactions","value":"209"}]},{"database":"FunCoup","id":"Q5SNT2","properties":[{"key":"Number of interactors","value":"504"}]},{"database":"IntAct","id":"Q5SNT2","properties":[{"key":"Interactions","value":"94"}]},{"database":"NDEx","id":"MUSIC2-C5188-TMEM201","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - Nuclear envelope and nucleocytoplasmic transport (49 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000344503","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.I.1.1.3","properties":[{"key":"FamilyName","value":"the nuclear pore complex (npc) family"}]},{"database":"GlyGen","id":"Q5SNT2","properties":[{"key":"glycosylation","value":"4 sites, 1 N-linked glycan (1 site), 2 O-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TMEM201","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74743441","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000344503","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"63760","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5SNT2-1"},{"database":"ProteomicsDB","id":"63761","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5SNT2-2"},{"database":"Pumba","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"62878","properties":[{"key":"antibodies","value":"21 antibodies from 8 providers"}]},{"database":"DNASU","id":"199953","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000340305.9","properties":[{"key":"ProteinId","value":"ENSP00000344772.5"},{"key":"GeneId","value":"ENSG00000188807.14"}],"isoformId":"Q5SNT2-2"},{"database":"Ensembl","id":"ENST00000340381.11","properties":[{"key":"ProteinId","value":"ENSP00000344503.6"},{"key":"GeneId","value":"ENSG00000188807.14"}],"isoformId":"Q5SNT2-1"},{"database":"GeneID","id":"199953","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:199953","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000340381.11","properties":[{"key":"ProteinId","value":"ENSP00000344503.6"},{"key":"RefSeqNucleotideId","value":"NM_001130924.3"},{"key":"RefSeqProteinId","value":"NP_001124396.2"}]},{"database":"UCSC","id":"uc001apy.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q5SNT2-1"},{"database":"AGR","id":"HGNC:33719","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162406359","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"199953","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"199953","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TMEM201","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:33719","properties":[{"key":"GeneName","value":"TMEM201"}]},{"database":"HPA","id":"ENSG00000188807","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (skeletal)"}]},{"database":"OpenTargets","id":"ENSG00000188807","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000188807","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4623","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002713","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_067578_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LCLGTMP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5966927at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q5SNT2","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000188807","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"199953","properties":[{"key":"hits","value":"27 hits in 1159 CRISPR screens"}]},{"database":"CD-CODE","id":"8C2F96ED","properties":[{"key":"EntryName","value":"Centrosome"}]},{"database":"ChiTaRS","id":"TMEM201","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"199953","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q5SNT2","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q5SNT2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q5SNT2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000188807","properties":[{"key":"ExpressionPatterns","value":"Expressed in cardiac muscle of right atrium and 158 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5SNT2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005635","properties":[{"key":"GoTerm","value":"C:nuclear envelope"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"GO","id":"GO:0005637","properties":[{"key":"GoTerm","value":"C:nuclear inner membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35311970"}]},{"database":"GO","id":"GO:0031965","properties":[{"key":"GoTerm","value":"C:nuclear membrane"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0000922","properties":[{"key":"GoTerm","value":"C:spindle pole"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0051015","properties":[{"key":"GoTerm","value":"F:actin filament binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005521","properties":[{"key":"GoTerm","value":"F:lamin binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"35311970"}]},{"database":"GO","id":"GO:0051642","properties":[{"key":"GoTerm","value":"P:centrosome localization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}]},{"database":"GO","id":"GO:0006998","properties":[{"key":"GoTerm","value":"P:nuclear envelope organization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}]},{"database":"GO","id":"GO:0030473","properties":[{"key":"GoTerm","value":"P:nuclear migration along microtubule"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0010595","properties":[{"key":"GoTerm","value":"P:positive regulation of endothelial cell migration"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"35311970"}]},{"database":"GO","id":"GO:0090435","properties":[{"key":"GoTerm","value":"P:protein localization to nuclear envelope"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}]},{"database":"InterPro","id":"IPR018617","properties":[{"key":"EntryName","value":"Ima1_N"}]},{"database":"InterPro","id":"IPR040041","properties":[{"key":"EntryName","value":"TMEM201"}]},{"database":"InterPro","id":"IPR018861","properties":[{"key":"EntryName","value":"TMEM201_C"}]},{"database":"PANTHER","id":"PTHR28646","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 201"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28646:SF1","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 201"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10476","properties":[{"key":"EntryName","value":"DUF2448"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09779","properties":[{"key":"EntryName","value":"Ima1_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEGVSALLARCPTAGLAGGLGVTACAAAGVLLYRIARRMKPTHTMVNCWFCNQDTLVPYGNRNCWDCPHCEQYNGFQENGDYNKPIPAQYLEHLNHVVSSAPSLRDPSQPQQWVSSQVLLCKRCNHHQTTKIKQLAAFAPREEGRYDEEVEVYRHHLEQMYKLCRPCQAAVEYYIKHQNRQLRALLLSHQFKRREADQTHAQNFSSAVKSPVQVILLRALAFLACAFLLTTALYGASGHFAPGTTVPLALPPGGNGSATPDNGTTPGAEGWRQLLGLLPEHMAEKLCEAWAFGQSHQTGVVALGLLTCLLAMLLAGRIRLRRIDAFCTCLWALLLGLHLAEQHLQAASPSWLDTLKFSTTSLCCLVGFTAAVATRKATGPRRFRPRRFFPGDSAGLFPTSPSLAIPHPSVGGSPASLFIPSPPSFLPLANQQLFRSPRRTSPSSLPGRLSRALSLGTIPSLTRADSGYLFSGSRPPSQVSRSGEFPVSDYFSLLSGSCPSSPLPSPAPSVAGSVASSSGSLRHRRPLISPARLNLKGQKLLLFPSPPGEAPTTPSSSDEHSPHNGSLFTMEPPHVPRKPPLQDVKHALDLRSKLERGSACSNRSIKKEDDSSQSSTCVVDTTTRGCSEEAATWRGRFGPSLVRGLLAVSLAANALFTSVFLYQSLR","length":666,"molWeight":72236,"crc64":"19A4E0F866838525","md5":"A9EC55D77EB3E73D58C1D2AC55B07C46"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":2,"INTERACTION":19,"SUBCELLULAR LOCATION":2,"ALTERNATIVE PRODUCTS":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":6,"Transmembrane":5,"Region":1,"Compositional bias":1,"Modified residue":9,"Alternative sequence":2,"Mutagenesis":2},"uniParcId":"UPI000022B297"}}