{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5QR91","secondaryAccessions":["B0QZI9","B9EK11","Q5SWU4"],"uniProtkbId":"CQ078_MOUSE","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2007-09-11","entryVersion":106,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C17orf78 homolog"}}},"genes":[{"geneName":{"value":"Gm11437"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":290,"modifier":"EXACT"}},"description":"Uncharacterized protein C17orf78 homolog","featureId":"PRO_0000300631"},{"type":"Transmembrane","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":276,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":64,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"in Ref. 1; CAH59902","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-82SIADN8EE5MV","citationType":"submission","authors":["Barber M.C.","Travers M.T."],"title":"Tissue-specific expression of a protein encoding gene located within intron 1 of the mammalian Acetyl-CoA carboxylase-alpha gene.","publicationDate":"OCT-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"SWR/J","type":"STRAIN"},{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AJ844653","properties":[{"key":"ProteinId","value":"CAH59902.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL596447","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC147775","properties":[{"key":"ProteinId","value":"AAI47776.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC147791","properties":[{"key":"ProteinId","value":"AAI47792.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS25184.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001033021.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001037932.2"}]},{"database":"AlphaFoldDB","id":"Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000056084","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000056084","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"284009","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"73298","properties":[{"key":"antibodies","value":"75 antibodies from 17 providers"}]},{"database":"Ensembl","id":"ENSMUST00000050771.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000056084.8"},{"key":"GeneId","value":"ENSMUSG00000051452.9"}]},{"database":"GeneID","id":"628813","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:628813","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007kqi.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:3650287","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:3650287","properties":[{"key":"GeneName","value":"Gm11437"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000051452","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SUFK","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008122","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_083643_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FIIFEVP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9118309at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"628813","properties":[{"key":"hits","value":"1 hit in 68 CRISPR screens"}]},{"database":"PRO","id":"PR:Q5QR91","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q5QR91","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000051452","properties":[{"key":"ExpressionPatterns","value":"Expressed in jejunum and 6 other cell types or tissues"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR031668","properties":[{"key":"EntryName","value":"DUF4711"}]},{"database":"PANTHER","id":"PTHR36870","properties":[{"key":"EntryName","value":"C17ORF78 ISOFORM 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR36870:SF1","properties":[{"key":"EntryName","value":"CHROMOSOME 17 C17ORF78 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15829","properties":[{"key":"EntryName","value":"DUF4711"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDTILVFSLMIASYDSNKNDLRKSSCQVEQWPSFFSEDVRSNKDLVVRVPLEIHTDTKGTPFIQNQPIATLRCLGSGRRVTVHLVYSERRPKVKYIMKNLPVITDLPRNSTASPRCHLRATSQFQNGSLLTAFLPGISQCTVYSAKDRSASSEMVPITTSSTTPRSKGDEATSTGAFPNPLTQGIDMSLKRRQKWSLVVKALIAVTLLLGGAAIIVFVIFEVPCPSQCLRVRQLCQCQWLWRRKRKEEDQKPGTTESQLDSQPEKVKHNVPNSSDSKKTTDIAIIYQTYF","length":290,"molWeight":32583,"crc64":"05D252420B2CB6EF","md5":"768D52D1BD12F702BC212B97D38FBFCB"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1},"countByFeatureType":{"Chain":1,"Transmembrane":1,"Region":2,"Compositional bias":2,"Sequence conflict":1},"uniParcId":"UPI00004CABE7"}}