{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5PQS5","uniProtkbId":"CYYR1_RAT","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2005-01-04","entryVersion":95,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Rattus norvegicus","commonName":"Rat","taxonId":10116,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Rattus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cysteine and tyrosine-rich protein 1"}},"flag":"Precursor"},"genes":[{"geneName":{"value":"Cyyr1"}}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CYYR1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Cysteine and tyrosine-rich protein 1","featureId":"PRO_0000341300"},{"type":"Topological domain","location":{"start":{"value":30,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":62,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":83,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC087052","properties":[{"key":"ProteinId","value":"AAH87052.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001014002.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001013980.1"}]},{"database":"AlphaFoldDB","id":"Q5PQS5","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q5PQS5","properties":[{"key":"Number of interactors","value":"68"}]},{"database":"STRING","id":"10116.ENSRNOP00000002109","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5PQS5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10116-ENSRNOP00000002109","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSRNOT00055003626","properties":[{"key":"ProteinId","value":"ENSRNOP00055002724"},{"key":"GeneId","value":"ENSRNOG00055002279"}]},{"database":"Ensembl","id":"ENSRNOT00060028852","properties":[{"key":"ProteinId","value":"ENSRNOP00060023222"},{"key":"GeneId","value":"ENSRNOG00060016867"}]},{"database":"Ensembl","id":"ENSRNOT00065009706","properties":[{"key":"ProteinId","value":"ENSRNOP00065007013"},{"key":"GeneId","value":"ENSRNOG00065006325"}]},{"database":"GeneID","id":"304138","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"rno:304138","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"RGD:1359578","properties":[{"key":"OrganismName","value":"rat"}]},{"database":"AGR","id":"RGD:1359578","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"116159","properties":[{"key":"Description","value":"-"}]},{"database":"RGD","id":"1359578","properties":[{"key":"GeneName","value":"Cyyr1"}]},{"database":"eggNOG","id":"ENOG502S121","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_143594_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5PQS5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YSYDYEM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"88589at9989","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q5PQS5","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q5PQS5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002494","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"Bgee","id":"ENSRNOG00000001544","properties":[{"key":"ExpressionPatterns","value":"Expressed in lung and 18 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5PQS5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR022640","properties":[{"key":"EntryName","value":"CYYR1"}]},{"database":"PANTHER","id":"PTHR38490","properties":[{"key":"EntryName","value":"CYSTEINE AND TYROSINE-RICH PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR38490:SF1","properties":[{"key":"EntryName","value":"CYSTEINE AND TYROSINE-RICH PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10873","properties":[{"key":"EntryName","value":"CYYR1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDALRLPRRLGVLLWKVVLLFVYAEDCRAQCGKDCRAYCCNGSTPHCCSYYAYIGSILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRAAHINAISYPMAPPPYTYDHETEYCTDLPPPYSPAPQASAQRSPPPPYPGNSRKYSSSQNRICNN","length":165,"molWeight":18050,"crc64":"5ADE3A327D935C2A","md5":"8E72A7CBE5E4CA621EBD642FC09A1708"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Region":1,"Compositional bias":1},"uniParcId":"UPI000024FF77"}}