{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5M8N4","secondaryAccessions":["Q3V467","Q8BWX0"],"uniProtkbId":"D39U1_MOUSE","entryAudit":{"firstPublicDate":"2007-03-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-02-13","entryVersion":140,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Epimerase family protein SDR39U1"},"ecNumbers":[{"value":"1.1.1.-"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NRG7"}],"value":"Short-chain dehydrogenase/reductase family 39U member 1"}}]},"genes":[{"geneName":{"value":"Sdr39u1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Putative NADP-dependent oxidoreductase"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous termination","sequence":"AAH87941.1","note":"Extended C-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":293,"modifier":"EXACT"}},"description":"Epimerase family protein SDR39U1","featureId":"PRO_0000279749"},{"type":"Binding site","location":{"start":{"value":31,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NRG7"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NRG7"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":77,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NRG7"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":82,"modifier":"EXACT"},"end":{"value":82,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NRG7"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Binding site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:58349"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NRG7"}],"ligand":{"name":"NADP(+)","id":"ChEBI:CHEBI:58349"}},{"type":"Sequence conflict","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"in Ref. 1; BAE43214","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0521","category":"Ligand","name":"NADP"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Spinal cord","type":"TISSUE"},{"value":"Tongue","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK009339","properties":[{"key":"ProteinId","value":"BAE43214.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK049709","properties":[{"key":"ProteinId","value":"BAC33886.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC087941","properties":[{"key":"ProteinId","value":"AAH87941.1"},{"key":"Status","value":"ALT_TERM"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS36935.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001076444.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001082975.1"}]},{"database":"AlphaFoldDB","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q5M8N4","properties":[{"key":"Number of interactors","value":"515"}]},{"database":"STRING","id":"10090.ENSMUSP00000106957","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q5M8N4","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000106957","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"279259","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"22920","properties":[{"key":"antibodies","value":"94 antibodies from 18 providers"}]},{"database":"Ensembl","id":"ENSMUST00000111325.5","properties":[{"key":"ProteinId","value":"ENSMUSP00000106957.4"},{"key":"GeneId","value":"ENSMUSG00000022223.10"}]},{"database":"GeneID","id":"654795","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:654795","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007ubc.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1916876","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"56948","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1916876","properties":[{"key":"GeneName","value":"Sdr39u1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022223","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3019","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000337","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_047373_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YLPWIHI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"276721at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"654795","properties":[{"key":"hits","value":"1 hit in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q5M8N4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"Q5M8N4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022223","properties":[{"key":"ExpressionPatterns","value":"Expressed in embryonic brain and 186 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5M8N4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"CDD","id":"cd05242","properties":[{"key":"EntryName","value":"SDR_a8"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.720","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-like Domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013549","properties":[{"key":"EntryName","value":"DUF1731"}]},{"database":"InterPro","id":"IPR001509","properties":[{"key":"EntryName","value":"Epimerase_deHydtase"}]},{"database":"InterPro","id":"IPR036291","properties":[{"key":"EntryName","value":"NAD(P)-bd_dom_sf"}]},{"database":"InterPro","id":"IPR010099","properties":[{"key":"EntryName","value":"SDR39U1"}]},{"database":"NCBIfam","id":"TIGR01777","properties":[{"key":"EntryName","value":"yfcH"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11092:SF0","properties":[{"key":"EntryName","value":"EPIMERASE FAMILY PROTEIN SDR39U1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11092","properties":[{"key":"EntryName","value":"SUGAR NUCLEOTIDE EPIMERASE RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08338","properties":[{"key":"EntryName","value":"DUF1731"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01370","properties":[{"key":"EntryName","value":"Epimerase"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51735","properties":[{"key":"EntryName","value":"NAD(P)-binding Rossmann-fold domains"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRVLVGGGTGFIGTAVTQLLRGRGHEVKLVSRQPGPGRITWSELSESGLPLCDVVINLAGENILNPLRRWNETFQKEVLTSRLDTTHLLAKAITETAHPPQAWILVTGVAYYQPSLTKEYDEDSPGGNFDFFSNLVTKWEAAARLPGESTRQVVVRSGVVLGRGGGAISHMLLPFRLGLGGPIGSGRQFFPWIHIGDLAGILNYALEANHVQGVLNGVAPASTTTNAEFAQALGAALGRPAFIPVPSTVVRAVFGERAIMLLEGQKVVPRRTLATGYQYSFPELRAALKDVVA","length":293,"molWeight":31458,"crc64":"C9A50AF7FE0B05A9","md5":"6364163EA5623D520EF17A1805063B2E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Binding site":5,"Sequence conflict":1},"uniParcId":"UPI00000EA742"}}