{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5JPI3","secondaryAccessions":["B2R8X6","Q8TC85"],"uniProtkbId":"CC038_HUMAN","entryAudit":{"firstPublicDate":"2006-07-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-02-15","entryVersion":136,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C3orf38"}}},"genes":[{"geneName":{"value":"C3orf38"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17464193"}],"value":"May be involved in apoptosis regulation"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q5JPI3-2","intActId":"EBI-12009184"},"interactantTwo":{"uniProtKBAccession":"O95429","geneName":"BAG4","intActId":"EBI-2949658"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q5JPI3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q5JPI3-2"],"sequenceIds":["VSP_019621"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Uncharacterized protein C3orf38","featureId":"PRO_0000244989"},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_019621","alternativeSequence":{}},{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"},"sequence":"Q5JPI3-2"},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"},"sequence":"Q5JPI3-2"},"description":"N-acetylserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"]},{"referenceNumber":2,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Lymph node","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"17464193","citationType":"journal article","authors":["Park K.M.","Kang E.","Jeon Y.-J.","Kim N.","Kim N.-S.","Yoo H.-S.","Yeom Y.I.","Kim S.J."],"citationCrossReferences":[{"database":"PubMed","id":"17464193"},{"database":"DOI","id":"10.1016/s1016-8478(23)07370-3"}],"title":"Identification of novel regulators of apoptosis using a high-throughput cell-based screen.","publicationDate":"2007","journal":"Mol. Cells","firstPage":"170","lastPage":"174","volume":"23"},"referencePositions":["FUNCTION"]},{"referenceNumber":5,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 (ISOFORM 2)","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS] (ISOFORM 2)","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK313547","properties":[{"key":"ProteinId","value":"BAG36323.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL832398","properties":[{"key":"ProteinId","value":"CAI46184.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC024188","properties":[{"key":"ProteinId","value":"AAH24188.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2921.2","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5JPI3-1"},{"database":"RefSeq","id":"NP_776185.2","properties":[{"key":"NucleotideSequenceId","value":"NM_173824.4"}],"isoformId":"Q5JPI3-1"},{"database":"AlphaFoldDB","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"130054","properties":[{"key":"Interactions","value":"19"}]},{"database":"FunCoup","id":"Q5JPI3","properties":[{"key":"Number of interactors","value":"3212"}]},{"database":"IntAct","id":"Q5JPI3","properties":[{"key":"Interactions","value":"14"}]},{"database":"NDEx","id":"MUSIC2-C5182-C3orf38","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - Chaperone-mediated protein folding complex (58 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000322469","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q5JPI3","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C3orf38","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74708031","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000322469","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"63017","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5JPI3-1"},{"database":"ProteomicsDB","id":"63018","properties":[{"key":"Description","value":"-"}],"isoformId":"Q5JPI3-2"},{"database":"Pumba","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"32056","properties":[{"key":"antibodies","value":"79 antibodies from 18 providers"}]},{"database":"DNASU","id":"285237","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000318887.8","properties":[{"key":"ProteinId","value":"ENSP00000322469.3"},{"key":"GeneId","value":"ENSG00000179021.11"}],"isoformId":"Q5JPI3-1"},{"database":"GeneID","id":"285237","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:285237","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000318887.8","properties":[{"key":"ProteinId","value":"ENSP00000322469.3"},{"key":"RefSeqNucleotideId","value":"NM_173824.4"},{"key":"RefSeqProteinId","value":"NP_776185.2"}]},{"database":"UCSC","id":"uc003dqw.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q5JPI3-1"},{"database":"AGR","id":"HGNC:28384","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672399","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"285237","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"285237","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C3orf38","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28384","properties":[{"key":"GeneName","value":"C3orf38"}]},{"database":"HPA","id":"ENSG00000179021","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000179021","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000179021","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RKN5","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000367","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_060119_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AKEYWCE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6407068at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q5JPI3","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000179021","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"285237","properties":[{"key":"hits","value":"175 hits in 1137 CRISPR screens"}]},{"database":"ChiTaRS","id":"C3orf38","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"285237","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q5JPI3","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q5JPI3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q5JPI3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000179021","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 181 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q5JPI3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17464193"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17464193"}]},{"database":"InterPro","id":"IPR026698","properties":[{"key":"EntryName","value":"C3orf38"}]},{"database":"InterPro","id":"IPR063724","properties":[{"key":"EntryName","value":"C3orf38_C"}]},{"database":"InterPro","id":"IPR063725","properties":[{"key":"EntryName","value":"C3orf38_N"}]},{"database":"InterPro","id":"IPR032710","properties":[{"key":"EntryName","value":"NTF2-like_dom_sf"}]},{"database":"PANTHER","id":"PTHR21084","properties":[{"key":"EntryName","value":"DENSE INCISORS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21084:SF1","properties":[{"key":"EntryName","value":"DENSE INCISORS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15008","properties":[{"key":"EntryName","value":"DUF4518"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF29669","properties":[{"key":"EntryName","value":"DUF4518_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54427","properties":[{"key":"EntryName","value":"NTF2-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEMSGLSFSEMEGCRNLLGLLDNDEIMALCDTVTNRLVQPQDRQDAVHAILAYSQSAEELLRRRKVHREVIFKYLATQGIVIPPATEKHNLIQHAKDYWQKQPQLKLKETPEPVTKTEDIHLFQQQVKEDKKAEKVDFRRLGEEFCHWFFGLLNSQNPFLGPPQDEWGPQHFWHDVKLRFYYNTSEQNVMDYHGAEIVSLRLLSLVKEEFLFLSPNLDSHGLKCASSPHGLVMVGVAGTVHRGNTCLGIFEQIFGLIRCPFVENTWKIKFINLKIMGESSLAPGTLPKPSVKFEQSDLEAFYNVITVCGTNEVRHNVKQASDSGTGDQV","length":329,"molWeight":37541,"crc64":"1D50C818B7F029ED","md5":"D5BC48FB7E7A60333C6CEC4045A5783D"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":1,"ALTERNATIVE PRODUCTS":2},"countByFeatureType":{"Chain":1,"Alternative sequence":1,"Initiator methionine":1,"Modified residue":1},"uniParcId":"UPI000004D308"}}