{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q5BPM6","secondaryAccessions":["Q6DYB8","Q9M1X6"],"uniProtkbId":"QWRF6_ARATH","entryAudit":{"firstPublicDate":"2013-10-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-04-12","entryVersion":101,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"QWRF motif-containing protein 6"}}},"genes":[{"geneName":{"value":"QWRF6"},"orderedLocusNames":[{"value":"At3g60000"}],"orfNames":[{"value":"F24G16.270"}]}],"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q5BPM6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q5BPM6-2"],"sequenceIds":["VSP_053221"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the QWRF family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"QWRF motif-containing protein 6","featureId":"PRO_0000423627"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":264,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"QWRF motif"},{"type":"Compositional bias","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":80,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":430,"modifier":"EXACT"},"end":{"value":442,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_053221","alternativeSequence":{"originalSequence":"VLNLSLHKLKNVL","alternativeSequences":["IEECSMRSQLIQQTTKEESSSK"]}},{"type":"Sequence conflict","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":135,"modifier":"EXACT"}},"description":"in Ref. 4; AAT67586","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"PP","alternativeSequences":["LS"]}},{"type":"Sequence conflict","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"in Ref. 4; AAT67586","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"11130713","citationType":"journal article","authors":["Salanoubat M.","Lemcke K.","Rieger M.","Ansorge W.","Unseld M.","Fartmann B.","Valle G.","Bloecker H.","Perez-Alonso M.","Obermaier B.","Delseny M.","Boutry M.","Grivell L.A.","Mache R.","Puigdomenech P.","De Simone V.","Choisne N.","Artiguenave F.","Robert C.","Brottier P.","Wincker P.","Cattolico L.","Weissenbach J.","Saurin W.","Quetier F.","Schaefer M.","Mueller-Auer S.","Gabel C.","Fuchs M.","Benes V.","Wurmbach E.","Drzonek H.","Erfle H.","Jordan N.","Bangert S.","Wiedelmann R.","Kranz H.","Voss H.","Holland R.","Brandt P.","Nyakatura G.","Vezzi A.","D'Angelo M.","Pallavicini A.","Toppo S.","Simionati B.","Conrad A.","Hornischer K.","Kauer G.","Loehnert T.-H.","Nordsiek G.","Reichelt J.","Scharfe M.","Schoen O.","Bargues M.","Terol J.","Climent J.","Navarro P.","Collado C.","Perez-Perez A.","Ottenwaelder B.","Duchemin D.","Cooke R.","Laudie M.","Berger-Llauro C.","Purnelle B.","Masuy D.","de Haan M.","Maarse A.C.","Alcaraz J.-P.","Cottet A.","Casacuberta E.","Monfort A.","Argiriou A.","Flores M.","Liguori R.","Vitale D.","Mannhaupt G.","Haase D.","Schoof H.","Rudd S.","Zaccaria P.","Mewes H.-W.","Mayer K.F.X.","Kaul S.","Town C.D.","Koo H.L.","Tallon L.J.","Jenkins J.","Rooney T.","Rizzo M.","Walts A.","Utterback T.","Fujii C.Y.","Shea T.P.","Creasy T.H.","Haas B.","Maiti R.","Wu D.","Peterson J.","Van Aken S.","Pai G.","Militscher J.","Sellers P.","Gill J.E.","Feldblyum T.V.","Preuss D.","Lin X.","Nierman W.C.","Salzberg S.L.","White O.","Venter J.C.","Fraser C.M.","Kaneko T.","Nakamura Y.","Sato S.","Kato T.","Asamizu E.","Sasamoto S.","Kimura T.","Idesawa K.","Kawashima K.","Kishida Y.","Kiyokawa C.","Kohara M.","Matsumoto M.","Matsuno A.","Muraki A.","Nakayama S.","Nakazaki N.","Shinpo S.","Takeuchi C.","Wada T.","Watanabe A.","Yamada M.","Yasuda M.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"11130713"},{"database":"DOI","id":"10.1038/35048706"}],"title":"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"820","lastPage":"822","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-ED99B0LS32EOA","citationType":"submission","authors":["Underwood B.A.","Xiao Y.-L.","Moskal W.A. Jr.","Monaghan E.L.","Wang W.","Redman J.C.","Wu H.C.","Utterback T.","Town C.D."],"publicationDate":"MAY-2004","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"20978221","citationType":"journal article","authors":["Albrecht V.","Simkova K.","Carrie C.","Delannoy E.","Giraud E.","Whelan J.","Small I.D.","Apel K.","Badger M.R.","Pogson B.J."],"citationCrossReferences":[{"database":"PubMed","id":"20978221"},{"database":"DOI","id":"10.1105/tpc.110.074781"}],"title":"The cytoskeleton and the peroxisomal-targeted snowy cotyledon3 protein are required for chloroplast development in Arabidopsis.","publicationDate":"2010","journal":"Plant Cell","firstPage":"3423","lastPage":"3438","volume":"22"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL138647","properties":[{"key":"ProteinId","value":"CAB75819.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002686","properties":[{"key":"ProteinId","value":"AEE80000.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002686","properties":[{"key":"ProteinId","value":"AEE80001.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408685","properties":[{"key":"ProteinId","value":"CAO7045120.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408685","properties":[{"key":"ProteinId","value":"CAO7045121.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY630787","properties":[{"key":"ProteinId","value":"AAT67586.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY924802","properties":[{"key":"ProteinId","value":"AAX23877.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"T47824","properties":[{"key":"EntryName","value":"T47824"}]},{"database":"RefSeq","id":"NP_001118860.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001125388.1"}],"isoformId":"Q5BPM6-2"},{"database":"RefSeq","id":"NP_191559.2","properties":[{"key":"NucleotideSequenceId","value":"NM_115863.4"}],"isoformId":"Q5BPM6-1"},{"database":"AlphaFoldDB","id":"Q5BPM6","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q5BPM6","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"825170","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT3G60000","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT3G60000","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT3G60000","properties":[{"key":"GeneName","value":"QWRF6"}]},{"database":"eggNOG","id":"ENOG502R98H","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q5BPM6","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PHPTSNK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"542108at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q5BPM6","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q5BPM6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"ExpressionAtlas","id":"Q5BPM6","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0051225","properties":[{"key":"GoTerm","value":"P:spindle assembly"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR007573","properties":[{"key":"EntryName","value":"QWRF"}]},{"database":"PANTHER","id":"PTHR31807","properties":[{"key":"EntryName","value":"AUGMIN FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31807:SF6","properties":[{"key":"EntryName","value":"PROTEIN ENDOSPERM DEFECTIVE 1-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04484","properties":[{"key":"EntryName","value":"QWRF"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEAKTSGPKQIQPSTPAPPPSTRRPRVREVSSRFMSPVTSSSSSAGDLHSLTCNSPKQHHLQHHQIQRSVSAQRLRRQLKMADGDENRSSETAARSLDSPFTLSQSRKSSKPSHLKPLNENSHRLETPTPMVPPPPSRSRLSQQRLPTATRLLQLSGISACYEKEGIINIQEKPKSNGSDQFPTLSCRTHLKVFNNPVPSSLNRSVSSPSSSCNVRESSSFSRLGLPLPPMAPKVPADTKKQRKVTEQLEDVHSLKLLHNRYLQWRFANANAQVKTQTHKTQTETMIHSFGSKISELHDSVQRKRIELQRLLKTKALLAITESQTPCLEQWSAIEEEYSTSVSQTIQAFSNASLRLPLDGDIMVDSKQLGDGLVAASKIVDGITQNVGNYMPKAKEMESLLSELTRVARSERSLTENCVVALLKTQASQVLNLSLHKLKNVL","length":442,"molWeight":49075,"crc64":"91BF7E43C6C18B7D","md5":"EB713032941E9ABAAB487F75BD702A81"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":2,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Motif":1,"Compositional bias":2,"Alternative sequence":1,"Sequence conflict":2},"uniParcId":"UPI00004EA624"}}