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With the RNA-binding protein (RBP) csdA, forms a post-transcriptional control network for secondary metabolites biosynthesis, csdA controlling the expression of laeB at the post-transcriptional level by influencing the alternative splicing of its pre-mRNA (By similarity). Once translated, the laeB protein is able to interact with csdA to form a regulatory complex to regulate the growth, development, and metabolism (By similarity). Controls the production of sterigmatocystin (ST) via the positive regulation of the aflR ST cluster-specific transcription factor (PubMed:28874473). Negatively regulates the production of several other natural products including porriolide, 3-methoxyporriolide, 7-methoxyporriolide, cichorine, gibellulin C, gibellulin D, asperthecin, and one NRPS-like product microperfuranone (PubMed:29947411)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"Interacts with csdA"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"The RNA-binding protein csdA mediates laeB expression by binding specific motif GUCGGUAU on laeB pre-mRNA for alternative splicing, regulating the stability of intron 2 splicing, thereby producing normal levels of laeB protein that interacts with csdA to regulate fungal growth, development and secondary metabolism"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28874473"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29947411"}],"value":"Exhibits a clear colony decoloration (PubMed:29947411). Leads to the loss of aflR expression and sterigmatocystin production during the induction of asexual development (PubMed:28874473). In contrast, leads to the activation of several secondary metabolism pathways including the biosynthesis of porriolide, 3-methoxyporriolide, 7-methoxyporriolide, cichorine, gibellulin C, gibellulin D, asperthecin and microperfuranone (PubMed:29947411)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the laeB global regulator family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"Global regulator 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