{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q59MA6","secondaryAccessions":["A0A1D8PDF6"],"uniProtkbId":"BMT2_CANAL","entryAudit":{"firstPublicDate":"2014-04-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2017-03-15","entryVersion":79,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Candida albicans (strain SC5314 / ATCC MYA-2876)","commonName":"Yeast","taxonId":237561,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Saccharomycotina","Pichiomycetes","Debaryomycetaceae","Candida/Lodderomyces clade","Candida"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Beta-mannosyltransferase 2"},"ecNumbers":[{"value":"2.4.1.-"}]},"alternativeNames":[{"fullName":{"value":"Repressed during hyphae development protein 1"}},{"fullName":{"value":"WRY family protein 7"}}]},"genes":[{"geneName":{"value":"RHD1"},"synonyms":[{"value":"BMT2"},{"value":"IFQ3"},{"value":"WRY7"}],"orderedLocusNames":[{"value":"CAALFM_C105000WA"}],"orfNames":[{"value":"CaO19.54"},{"value":"CaO19.7715"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18234669"}],"value":"Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Membrane","id":"SL-0162"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12388749"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12397174"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22265407"}],"value":"Regulated on yeast-hypha and white-opaque switches, and repressed in biofilm"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18234669"}],"value":"Impairs the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BMT family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Beta-mannosyltransferase 2","featureId":"PRO_0000426070"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0961","category":"Biological process","name":"Cell wall biogenesis/degradation"},{"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0735","category":"Domain","name":"Signal-anchor"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"15123810","citationType":"journal article","authors":["Jones T.","Federspiel N.A.","Chibana H.","Dungan J.","Kalman S.","Magee B.B.","Newport G.","Thorstenson Y.R.","Agabian N.","Magee P.T.","Davis R.W.","Scherer S."],"citationCrossReferences":[{"database":"PubMed","id":"15123810"},{"database":"DOI","id":"10.1073/pnas.0401648101"}],"title":"The diploid genome sequence of Candida albicans.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7329","lastPage":"7334","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"SC5314 / ATCC MYA-2876","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"17419877","citationType":"journal article","authors":["van het Hoog M.","Rast T.J.","Martchenko M.","Grindle S.","Dignard D.","Hogues H.","Cuomo C.","Berriman M.","Scherer S.","Magee B.B.","Whiteway M.","Chibana H.","Nantel A.","Magee P.T."],"citationCrossReferences":[{"database":"PubMed","id":"17419877"},{"database":"DOI","id":"10.1186/gb-2007-8-4-r52"}],"title":"Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomes.","publicationDate":"2007","journal":"Genome Biol.","firstPage":"RESEARCH52.1","lastPage":"RESEARCH52.12","volume":"8"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"SC5314 / ATCC MYA-2876","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"24025428","citationType":"journal article","authors":["Muzzey D.","Schwartz K.","Weissman J.S.","Sherlock G."],"citationCrossReferences":[{"database":"PubMed","id":"24025428"},{"database":"DOI","id":"10.1186/gb-2013-14-9-r97"}],"title":"Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.","publicationDate":"2013","journal":"Genome Biol.","firstPage":"RESEARCH97.1","lastPage":"RESEARCH97.14","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]","GENOME REANNOTATION"],"referenceComments":[{"value":"SC5314 / ATCC MYA-2876","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"12388749","citationType":"journal article","authors":["Nantel A.","Dignard D.","Bachewich C.","Harcus D.","Marcil A.","Bouin A.P.","Sensen C.W.","Hogues H.","van het Hoog M.","Gordon P.","Rigby T.","Benoit F.","Tessier D.C.","Thomas D.Y.","Whiteway M."],"citationCrossReferences":[{"database":"PubMed","id":"12388749"},{"database":"DOI","id":"10.1091/mbc.e02-05-0272"}],"title":"Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.","publicationDate":"2002","journal":"Mol. Biol. Cell","firstPage":"3452","lastPage":"3465","volume":"13"},"referencePositions":["INDUCTION"]},{"referenceNumber":5,"citation":{"id":"12397174","citationType":"journal article","authors":["Lan C.Y.","Newport G.","Murillo L.A.","Jones T.","Scherer S.","Davis R.W.","Agabian N."],"citationCrossReferences":[{"database":"PubMed","id":"12397174"},{"database":"DOI","id":"10.1073/pnas.232566499"}],"title":"Metabolic specialization associated with phenotypic switching in Candidaalbicans.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"14907","lastPage":"14912","volume":"99"},"referencePositions":["INDUCTION"]},{"referenceNumber":6,"citation":{"id":"18234669","citationType":"journal article","authors":["Mille C.","Bobrowicz P.","Trinel P.A.","Li H.","Maes E.","Guerardel Y.","Fradin C.","Martinez-Esparza M.","Davidson R.C.","Janbon G.","Poulain D.","Wildt S."],"citationCrossReferences":[{"database":"PubMed","id":"18234669"},{"database":"DOI","id":"10.1074/jbc.m708825200"}],"title":"Identification of a new family of genes involved in beta-1,2-mannosylation of glycans in Pichia pastoris and Candida albicans.","publicationDate":"2008","journal":"J. Biol. Chem.","firstPage":"9724","lastPage":"9736","volume":"283"},"referencePositions":["IDENTIFICATION","DISRUPTION PHENOTYPE","FUNCTION"]},{"referenceNumber":7,"citation":{"id":"22265407","citationType":"journal article","authors":["Nobile C.J.","Fox E.P.","Nett J.E.","Sorrells T.R.","Mitrovich Q.M.","Hernday A.D.","Tuch B.B.","Andes D.R.","Johnson A.D."],"citationCrossReferences":[{"database":"PubMed","id":"22265407"},{"database":"DOI","id":"10.1016/j.cell.2011.10.048"}],"title":"A recently evolved transcriptional network controls biofilm development in Candida albicans.","publicationDate":"2012","journal":"Cell","firstPage":"126","lastPage":"138","volume":"148"},"referencePositions":["INDUCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"CP017623","properties":[{"key":"ProteinId","value":"AOW26172.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_710865.2","properties":[{"key":"NucleotideSequenceId","value":"XM_705773.2"}]},{"database":"AlphaFoldDB","id":"Q59MA6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q59MA6","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"237561.Q59MA6","properties":[{"key":"Description","value":"-"}]},{"database":"CAZy","id":"GT91","properties":[{"key":"FamilyName","value":"Glycosyltransferase Family 91"}]},{"database":"PaxDb","id":"237561-Q59MA6","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"C1_05000W_A-T","properties":[{"key":"ProteinId","value":"C1_05000W_A-T-p1"},{"key":"GeneId","value":"C1_05000W_A"}]},{"database":"GeneID","id":"3647531","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"cal:CAALFM_C105000WA","properties":[{"key":"Description","value":"-"}]},{"database":"CGD","id":"CAL0000199919","properties":[{"key":"GeneName","value":"RHD1"}]},{"database":"VEuPathDB","id":"FungiDB:C1_05000W_A","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QTZG","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_013841_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q59MA6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"3631276at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q59MA6","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000559","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0000030","properties":[{"key":"GoTerm","value":"F:mannosyltransferase activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0070135","properties":[{"key":"GoTerm","value":"P:beta-1,2-oligomannoside metabolic process"},{"key":"GoEvidenceType","value":"IMP:CGD"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18234669"}]},{"database":"GO","id":"GO:0006688","properties":[{"key":"GoTerm","value":"P:glycosphingolipid biosynthetic process"},{"key":"GoEvidenceType","value":"IGI:CGD"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"26427558"}]},{"database":"InterPro","id":"IPR021988","properties":[{"key":"EntryName","value":"BMT1"}]},{"database":"Pfam","id":"PF12141","properties":[{"key":"EntryName","value":"BMT"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLAWLRHRIRSYNTSTYSSILPSASFGKVYKIGTKLNFTLLALCLLLACSVFFNYFYLADNNGLDIDTKGEEEENVFKDRKMVIFPNNFEITDKNLLEYYLKTLEEPLHPQDTIYRNRFIYKVPDVSYTSQTINLFSGLSQNSQSSKCEDLSSSYSFDVSGPQNKNCDLYKVLGKFLNDDSEYFQEISPLFPKLKEMLVKKEIEKHWFQLIGSSVWLEQYGVHLMTSRIFYSSTGDKVKPVVSLTYVQVFDHEWREIENVELIVPDGEGKYKPMTYPTFLPMSVYHNEKQQQGRFYGVEDPRITLVRNKLGYDEPIIVYNSHHRKITDAKSDNDGESNIHFKAYRSIFMAWLWQNQKGKNNVEEIETGKMKNRVYVKSKELIKPNNKREDKEKNWAPFINYQQRLQQGFDSHVYFMYQFQDLKILKCSLLDEEDCVWEYQFNDKNGAGRLRGGTELVNINQLLTTFDHPEIKRVKDLMPQNREIWIGVARAALEKCGCGDKMYRPNIVILIKDGDDQYRLSHVSPFVGLGIPILPWWPDKGLCDGKNLIIPNGISSWHLNKDEDNSVQDYLTLSISRADSTVDLLHIKGLLKSILFDDPNSKLLELNDYGFNNKNIECAVKSSDAFCKKYGSEYKLNNNKEEDKANGNGKGSSS","length":654,"molWeight":75813,"crc64":"0C2ADD765D42F3F0","md5":"3BC7B9542FCEAAD93F3FF7565184FB4A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":2,"Transmembrane":1},"uniParcId":"UPI00052F7E22"}}