{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q59064","uniProtkbId":"CSM2_METJA","entryAudit":{"firstPublicDate":"2000-12-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":98,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","commonName":"Methanococcus jannaschii","taxonId":243232,"lineage":["Archaea","Methanobacteriati","Methanobacteriota","Methanomada group","Methanococci","Methanococcales","Methanocaldococcaceae","Methanocaldococcus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"CRISPR system Cms protein Csm2"}},"alternativeNames":[{"fullName":{"value":"CRISPR type III A-associated protein Csm2"}}]},"genes":[{"geneName":{"value":"csm2"},"orderedLocusNames":[{"value":"MJ1670"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0A7HIX1"}],"value":"CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The type III-A Csm effector complex binds crRNA and acts as a crRNA-guided RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA cognate to the crRNA is required for all activities"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0A7HIX1"}],"value":"This subunit may be involved in monitoring complementarity of crRNA and target RNA"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A0A7HIX1"}],"value":"Part of the Csm effector complex that includes Cas10, Csm2, Csm3, Csm4 and Csm5"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Encoded in a type III-A CRISPR locus"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CRISPR-associated Csm2 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"CRISPR system Cms protein Csm2","featureId":"PRO_0000107468"}],"keywords":[{"id":"KW-0051","category":"Biological process","name":"Antiviral defense"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"}],"references":[{"referenceNumber":1,"citation":{"id":"8688087","citationType":"journal article","authors":["Bult C.J.","White O.","Olsen G.J.","Zhou L.","Fleischmann R.D.","Sutton G.G.","Blake J.A.","FitzGerald L.M.","Clayton R.A.","Gocayne J.D.","Kerlavage A.R.","Dougherty B.A.","Tomb J.-F.","Adams M.D.","Reich C.I.","Overbeek R.","Kirkness E.F.","Weinstock K.G.","Merrick J.M.","Glodek A.","Scott J.L.","Geoghagen N.S.M.","Weidman J.F.","Fuhrmann J.L.","Nguyen D.","Utterback T.R.","Kelley J.M.","Peterson J.D.","Sadow P.W.","Hanna M.C.","Cotton M.D.","Roberts K.M.","Hurst M.A.","Kaine B.P.","Borodovsky M.","Klenk H.-P.","Fraser C.M.","Smith H.O.","Woese C.R.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"8688087"},{"database":"DOI","id":"10.1126/science.273.5278.1058"}],"title":"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.","publicationDate":"1996","journal":"Science","firstPage":"1058","lastPage":"1073","volume":"273"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L77117","properties":[{"key":"ProteinId","value":"AAB99693.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"D64508","properties":[{"key":"EntryName","value":"D64508"}]},{"database":"RefSeq","id":"WP_010871194.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000909.1"}]},{"database":"AlphaFoldDB","id":"Q59064","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q59064","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q59064","properties":[{"key":"Number of interactors","value":"1"}]},{"database":"STRING","id":"243232.MJ_1670","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"243232-MJ_1670","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAB99693","properties":[{"key":"ProteinId","value":"AAB99693"},{"key":"GeneId","value":"MJ_1670"}]},{"database":"GeneID","id":"1452579","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mja:MJ_1670","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"arCOG06487","properties":[{"key":"ToxonomicScope","value":"Archaea"}]},{"database":"HOGENOM","id":"CLU_131491_2_0_2","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q59064","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"65911at2157","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q59064","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000805","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"CDD","id":"cd09647","properties":[{"key":"EntryName","value":"Csm2_III-A"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR010149","properties":[{"key":"EntryName","value":"CRISPR-assoc_prot_Csm2_III-A"}]},{"database":"NCBIfam","id":"TIGR01870","properties":[{"key":"EntryName","value":"cas_TM1810_Csm2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03750","properties":[{"key":"EntryName","value":"Csm2_III-A"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSKIGKCILNPNEINLILNINSQNANEIIDIAENLAKEFEQIPATKMRDFYDYVLRIDEKNENWYKELVLLKPKLAYNYGKETNRRKKEALEKLAGTFSEIIDKIDNDLNKFKNFKTFFEALVAYHKIYAKSQ","length":133,"molWeight":15670,"crc64":"EF803498557B6898","md5":"6DEF62A4E3F5E0588FCD04A38FE7DDAC"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"SUBUNIT":1,"MISCELLANEOUS":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1},"uniParcId":"UPI000013AFDE"}}