{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q58185","uniProtkbId":"MPTA_METJA","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2025-06-18","lastSequenceUpdateDate":"2009-05-05","entryVersion":121,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","commonName":"Methanococcus jannaschii","taxonId":243232,"lineage":["Archaea","Methanobacteriati","Methanobacteriota","Methanomada group","Methanococci","Methanococcales","Methanocaldococcaceae","Methanocaldococcus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"GTP cyclohydrolase MptA"},"ecNumbers":[{"value":"3.5.4.39"}]},"alternativeNames":[{"fullName":{"value":"GTP cyclohydrolase IV"}}]},"genes":[{"geneName":{"value":"mptA"},"orderedLocusNames":[{"value":"MJ0775"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17497938"}],"value":"Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. It is also able to utilize a variety of GTP analogs as substrates, including GDP, beta,gamma-methylene-GTP and GTP-[gamma-thio]"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:25860"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:15740"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:58854"}],"ecNumber":"3.5.4.39","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17497938"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Fe(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17497938"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29033"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17497938"}],"value":"Binds 1 Fe(2+) ion per subunit. 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product"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the GTP cyclohydrolase IV family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAB98765.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"GTP cyclohydrolase MptA","featureId":"PRO_0000147743"},{"type":"Site","location":{"start":{"value":160,"modifier":"EXACT"},"end":{"value":160,"modifier":"EXACT"}},"description":"May be catalytically 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