{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q57665","uniProtkbId":"ALBA_METJA","entryAudit":{"firstPublicDate":"1997-11-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"1996-11-01","entryVersion":125,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)","commonName":"Methanococcus jannaschii","taxonId":243232,"lineage":["Archaea","Methanobacteriati","Methanobacteriota","Methanomada group","Methanococci","Methanococcales","Methanocaldococcaceae","Methanocaldococcus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"DNA/RNA-binding protein Alba"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"albA"},"orderedLocusNames":[{"value":"MJ0212"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"Binds double-stranded DNA tightly but without sequence specificity. Involved in DNA compaction"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"Chromosome","id":"SL-0468"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"Acetylated. Acetylation at Lys-9 decreases DNA-binding affinity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}],"value":"Belongs to the histone-like Alba family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"DNA/RNA-binding protein Alba","featureId":"PRO_0000151698"},{"type":"Modified residue","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":9,"modifier":"EXACT"}},"description":"N6-acetyllysine","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01122"}]},{"type":"Beta strand","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":7,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Helix","location":{"start":{"value":12,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Beta strand","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Helix","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Helix","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Helix","location":{"start":{"value":48,"modifier":"EXACT"},"end":{"value":52,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Beta strand","location":{"start":{"value":57,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]},{"type":"Beta strand","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"1NH9"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0226","category":"Biological process","name":"DNA condensation"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"8688087","citationType":"journal article","authors":["Bult C.J.","White O.","Olsen G.J.","Zhou L.","Fleischmann R.D.","Sutton G.G.","Blake J.A.","FitzGerald L.M.","Clayton R.A.","Gocayne J.D.","Kerlavage A.R.","Dougherty B.A.","Tomb J.-F.","Adams M.D.","Reich C.I.","Overbeek R.","Kirkness E.F.","Weinstock K.G.","Merrick J.M.","Glodek A.","Scott J.L.","Geoghagen N.S.M.","Weidman J.F.","Fuhrmann J.L.","Nguyen D.","Utterback T.R.","Kelley J.M.","Peterson J.D.","Sadow P.W.","Hanna M.C.","Cotton M.D.","Roberts K.M.","Hurst M.A.","Kaine B.P.","Borodovsky M.","Klenk H.-P.","Fraser C.M.","Smith H.O.","Woese C.R.","Venter J.C."],"citationCrossReferences":[{"database":"PubMed","id":"8688087"},{"database":"DOI","id":"10.1126/science.273.5278.1058"}],"title":"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.","publicationDate":"1996","journal":"Science","firstPage":"1058","lastPage":"1073","volume":"273"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"L77117","properties":[{"key":"ProteinId","value":"AAB98197.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"E64326","properties":[{"key":"EntryName","value":"E64326"}]},{"database":"RefSeq","id":"WP_010869708.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000909.1"}]},{"database":"PDB","id":"1NH9","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.00 A"},{"key":"Chains","value":"A=1-87"}]},{"database":"PDBsum","id":"1NH9","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q57665","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q57665","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q57665","properties":[{"key":"Number of interactors","value":"1"}]},{"database":"STRING","id":"243232.MJ_0212","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"243232-MJ_0212","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"AAB98197","properties":[{"key":"ProteinId","value":"AAB98197"},{"key":"GeneId","value":"MJ_0212"}]},{"database":"GeneID","id":"1451062","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mja:MJ_0212","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"arCOG01753","properties":[{"key":"ToxonomicScope","value":"Archaea"}]},{"database":"HOGENOM","id":"CLU_110989_1_0_2","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q57665","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10360at2157","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q57665","properties":[{"key":"Description","value":"-"}]},{"database":"EvolutionaryTrace","id":"Q57665","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000805","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0003690","properties":[{"key":"GoTerm","value":"F:double-stranded DNA binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"Gene3D","id":"3.30.110.20","properties":[{"key":"EntryName","value":"Alba-like domain"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01122","properties":[{"key":"EntryName","value":"AlbA"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR036882","properties":[{"key":"EntryName","value":"Alba-like_dom_sf"}]},{"database":"InterPro","id":"IPR013795","properties":[{"key":"EntryName","value":"DNA/RNA-bd_Alba"}]},{"database":"InterPro","id":"IPR002775","properties":[{"key":"EntryName","value":"DNA/RNA-bd_Alba-like"}]},{"database":"NCBIfam","id":"TIGR00285","properties":[{"key":"EntryName","value":"DNA-binding protein Alba"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF003088","properties":[{"key":"EntryName","value":"PRK04015.1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01918","properties":[{"key":"EntryName","value":"Alba"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF028732","properties":[{"key":"EntryName","value":"Alba"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82704","properties":[{"key":"EntryName","value":"AlbA-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDNVVLIGKKPVMNYVVAVLTQLTSNDEVIIKARGKAINKAVDVAEMIRNRFIKDIKIKKIEIGTDKVKNPDGREVNVSTIEIVLAK","length":87,"molWeight":9675,"crc64":"50B16E3E9D2DB157","md5":"C5495B42B0AC5978CB37281838EADED5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Modified residue":1,"Beta strand":4,"Helix":4},"uniParcId":"UPI0000139482"}}