{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q570Q8","secondaryAccessions":["Q9LUY1"],"uniProtkbId":"DDPS5_ARATH","entryAudit":{"firstPublicDate":"2005-09-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-09-13","entryVersion":125,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Dehydrodolichyl diphosphate synthase 5"},"shortNames":[{"value":"Dedol-PP synthase 5"}],"ecNumbers":[{"value":"2.5.1.-"}]}},"genes":[{"orderedLocusNames":[{"value":"At5g58784"}],"orfNames":[{"value":"MZN1.24"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein"}],"commentType":"FUNCTION"},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPP synthase family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":302,"modifier":"EXACT"}},"description":"Dehydrodolichyl diphosphate synthase 5","featureId":"PRO_0000123755"},{"type":"Transmembrane","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"10718197","citationType":"journal article","authors":["Sato S.","Nakamura Y.","Kaneko T.","Katoh T.","Asamizu E.","Kotani H.","Tabata S."],"citationCrossReferences":[{"database":"PubMed","id":"10718197"},{"database":"DOI","id":"10.1093/dnares/7.1.31"}],"title":"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones.","publicationDate":"2000","journal":"DNA Res.","firstPage":"31","lastPage":"63","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"CI-B9D7AITG0S7MM","citationType":"submission","authors":["Totoki Y.","Seki M.","Ishida J.","Nakajima M.","Enju A.","Kamiya A.","Narusaka M.","Shin-i T.","Nakagawa M.","Sakamoto N.","Oishi K.","Kohara Y.","Kobayashi M.","Toyoda A.","Sakaki Y.","Sakurai T.","Iida K.","Akiyama K.","Satou M.","Toyoda T.","Konagaya A.","Carninci P.","Kawai J.","Hayashizaki Y.","Shinozaki K."],"title":"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.","publicationDate":"MAR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-302"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB020755","properties":[{"key":"ProteinId","value":"BAA97348.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002688","properties":[{"key":"ProteinId","value":"AED97099.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408687","properties":[{"key":"ProteinId","value":"CAO7057031.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK220649","properties":[{"key":"ProteinId","value":"BAD95141.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_568884.4","properties":[{"key":"NucleotideSequenceId","value":"NM_125267.5"}]},{"database":"AlphaFoldDB","id":"Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q570Q8","properties":[{"key":"Number of interactors","value":"15"}]},{"database":"STRING","id":"3702.Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"224588","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"835994","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT5G58784","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT5G58784","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT5G58784","properties":[{"key":"GeneName","value":"-"}]},{"database":"eggNOG","id":"KOG1602","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_038505_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RRWAQKR","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"4173905at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"ARA:AT5G58784-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"UniPathway","id":"UPA00378","properties":[{"key":"RectionId","value":"-"}]},{"database":"PRO","id":"PR:Q570Q8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"ExpressionAtlas","id":"Q570Q8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"ISM:TAIR"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0120531","properties":[{"key":"GoTerm","value":"F:prenyl diphosphate synthase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-ARBA"}]},{"database":"GO","id":"GO:0016094","properties":[{"key":"GoTerm","value":"P:polyprenol biosynthetic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd00475","properties":[{"key":"EntryName","value":"Cis_IPPS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.1180.10:FF:000001","properties":[{"key":"EntryName","value":"(2E,6E)-farnesyl-diphosphate-specific ditrans,polycis-undecaprenyl-diphosphate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1180.10","properties":[{"key":"EntryName","value":"Decaprenyl diphosphate synthase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01139","properties":[{"key":"EntryName","value":"ISPT"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001441","properties":[{"key":"EntryName","value":"UPP_synth-like"}]},{"database":"InterPro","id":"IPR018520","properties":[{"key":"EntryName","value":"UPP_synth-like_CS"}]},{"database":"InterPro","id":"IPR036424","properties":[{"key":"EntryName","value":"UPP_synth-like_sf"}]},{"database":"NCBIfam","id":"TIGR00055","properties":[{"key":"EntryName","value":"uppS"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10291:SF20","properties":[{"key":"EntryName","value":"DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE 5"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR10291","properties":[{"key":"EntryName","value":"DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01255","properties":[{"key":"EntryName","value":"Prenyltransf"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF64005","properties":[{"key":"EntryName","value":"Undecaprenyl diphosphate synthase"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01066","properties":[{"key":"EntryName","value":"UPP_SYNTHASE"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLSLFSVVFTFLALFLIPGLFISRRLNVPLSLTNILRFIKIIASKYDDEEERNEKRGTMGEKQKRGRNIMPKHVAVILDGNRRWAEKRGLGTSEGHEAGARRLMENAKDCFAMGTNTISLFAFSTENWERPEDEVKCLMALFEKYLASDMPYLRSDKIKISVIGNRTKLPESLLGLIEEVEEATKSYEGKNLIIAIDYSGRYDILQACKSLANKVKDGLIQVEDINEKAMEKELLTKCSEFPNPDLLIRTSGEQRISNFFLWQSAYTELYFPTVLWPDFGEAEYLEALTWYQQRQRRFGRRV","length":302,"molWeight":34893,"crc64":"C35020DDF4936ABE","md5":"7561C461AC14BECEE83A63BFAC205F49"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"COFACTOR":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":1},"uniParcId":"UPI00000A6FD0"}}