{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q53HL2","secondaryAccessions":["D3DPT4","Q53HN1","Q96AM3","Q9NVW5"],"uniProtkbId":"BOREA_HUMAN","entryAudit":{"firstPublicDate":"2006-07-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-07-25","entryVersion":170,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Borealin"}},"alternativeNames":[{"fullName":{"value":"Cell division cycle-associated protein 8"}},{"fullName":{"value":"Dasra-B"},"shortNames":[{"value":"hDasra-B"}]},{"fullName":{"value":"Pluripotent embryonic stem cell-related gene 3 protein"}}]},"genes":[{"geneName":{"value":"CDCA8"},"synonyms":[{"value":"PESCRG3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15249581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15260989"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16571674"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18243099"}],"value":"Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15249581"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16239925"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16291752"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16427043"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16436504"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17956729"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18591255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18946085"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20739936"}],"value":"May form homooligomers and homodimers. 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Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on 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