{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q52KN3","uniProtkbId":"CA216_XENLA","entryAudit":{"firstPublicDate":"2007-11-13","lastAnnotationUpdateDate":"2025-04-09","lastSequenceUpdateDate":"2007-11-13","entryVersion":43,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Xenopus laevis","commonName":"African clawed frog","taxonId":8355,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Amphibia","Batrachia","Anura","Pipoidea","Pipidae","Xenopodinae","Xenopus","Xenopus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0500 protein C1orf216 homolog"}}},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0500 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAH94267.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":281,"modifier":"EXACT"}},"description":"UPF0500 protein C1orf216 homolog","featureId":"PRO_0000309180"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":257,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":45,"modifier":"EXACT"},"end":{"value":74,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-8CMPP7NOODVGO","citationType":"submission","authoringGroup":["NIH - Xenopus Gene Collection (XGC) project"],"publicationDate":"APR-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC094267","properties":[{"key":"ProteinId","value":"AAH94267.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001090024.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001096555.1"}]},{"database":"AlphaFoldDB","id":"Q52KN3","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q52KN3","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"735096","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"735096","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"xla:735096","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"Xenbase:XB-GENE-1006876","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"735096","properties":[{"key":"Description","value":"-"}]},{"database":"Xenbase","id":"XB-GENE-1006876","properties":[{"key":"GeneName","value":"c2h1orf216.S"}]},{"database":"OrthoDB","id":"9900901at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000186698","properties":[{"key":"Component","value":"Chromosome 2S"}]},{"database":"Bgee","id":"735096","properties":[{"key":"ExpressionPatterns","value":"Expressed in brain and 6 other cell types or tissues"}]},{"database":"InterPro","id":"IPR027812","properties":[{"key":"EntryName","value":"DUF4653"}]},{"database":"PANTHER","id":"PTHR35673","properties":[{"key":"EntryName","value":"UPF0500 PROTEIN C1ORF216"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35673:SF1","properties":[{"key":"EntryName","value":"UPF0500 PROTEIN C1ORF216"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15546","properties":[{"key":"EntryName","value":"DUF4653"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFTIQKPDTVSHLSHFHESKSLGSLPFPSDKERKQDTNFNILEETYDKNENWSQDKKGGEEGENKSKSEDEHSSLDNNRSQLKNRPIGQLKSTGSEGISLSSSEEEVRSPPEGAEIMQLEGDTPANDTANGFEKWAGSPLEDNGYASSSLSIDSPDSVSASTWQETTLPAPTTTPQENPETEDSDVESSSDSDSISVTLSEAFQSLQDKEKLKEREKEKHHAQLTMYRRLALLRWIRALQQKVRDQQNRLQESFDTILDNRKEMLRHMQHGYNKTPTKEAV","length":281,"molWeight":31743,"crc64":"ECDDFD2CE3287243","md5":"A743CB0F02A91CCF2EF633A3C3F038BB"},"extraAttributes":{"countByCommentType":{"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Coiled coil":1,"Compositional bias":6},"uniParcId":"UPI00015E1606"}}