ID   FNDC1_HUMAN             Reviewed;        1894 AA.
AC   Q4ZHG4; A6H8X2; B7ZBR4; B7ZBR5; B9EK49; Q5JPI0; Q5VU31; Q5VU32; Q5VXX4;
AC   Q70CQ6; Q96JG1;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 4.
DT   24-JAN-2024, entry version 146.
DE   RecName: Full=Fibronectin type III domain-containing protein 1;
DE   AltName: Full=Activation-associated cDNA protein;
DE   AltName: Full=Expressed in synovial lining protein;
DE   Flags: Precursor;
GN   Name=FNDC1; Synonyms=FNDC2, KIAA1866, MEL4B3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS 1479-THR--THR-1484 DEL
RP   AND LYS-1504.
RX   PubMed=9704633;
RX   DOI=10.1002/1529-0131(199808)41:8<1356::aid-art4>3.0.co;2-x;
RA   Seki T., Selby J., Haupl T., Winchester R.;
RT   "Use of differential subtraction method to identify genes that characterize
RT   the phenotype of cultured rheumatoid arthritis synoviocytes.";
RL   Arthritis Rheum. 41:1356-1364(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORM 2), AND VARIANTS
RP   GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND
RP   LYS-1504.
RC   TISSUE=Brain;
RX   PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA   Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XX. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 8:85-95(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORMS 1 AND 2), AND
RP   VARIANTS ALA-438; GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280;
RP   1479-THR--THR-1484 DEL AND LYS-1504.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1196-1894 (ISOFORM 1), AND
RP   VARIANTS PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND LYS-1504.
RC   TISSUE=Lymph node;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1295-1894 (ISOFORM 1), INDUCTION BY TGFB1,
RP   AND VARIANTS 1479-THR--THR-1484 DEL AND LYS-1504.
RX   PubMed=16098131; DOI=10.1111/j.0906-6705.2005.00349.x;
RA   Anderegg U., Breitschwerdt K., Koehler M.J., Sticherling M.,
RA   Haustein U.-F., Simon J.C., Saalbach A.;
RT   "MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta
RT   and pro-inflammatory cytokines.";
RL   Exp. Dermatol. 14:709-718(2005).
CC   -!- FUNCTION: May be an activator of G protein signaling. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q4ZHG4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q4ZHG4-2; Sequence=VSP_024663;
CC   -!- TISSUE SPECIFICITY: Almost absent from healthy skin; especially in
CC       epidermal keratinocytes, skin fibroblasts or endothelial cells and is
CC       barely detectable in benign melanocytic naevi. Expressed in the stroma
CC       close to skin tumors, in the tumor cells themselves and in the
CC       epidermis of psoriasis.
CC   -!- INDUCTION: By TGFB1 present in the melanoma cell conditioned medium
CC       (MCCM). {ECO:0000269|PubMed:16098131}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-53 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI46784.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI50608.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAY26234.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAE51894.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DQ009660; AAY26234.1; ALT_INIT; mRNA.
DR   EMBL; AL355492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL356417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB058769; BAB47495.2; -; mRNA.
DR   EMBL; BC146783; AAI46784.1; ALT_INIT; mRNA.
DR   EMBL; BC150607; AAI50608.1; ALT_INIT; mRNA.
DR   EMBL; AL832410; CAI46178.2; -; mRNA.
DR   EMBL; AJ586132; CAE51894.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS47512.1; -. [Q4ZHG4-1]
DR   RefSeq; NP_115921.2; NM_032532.2. [Q4ZHG4-1]
DR   AlphaFoldDB; Q4ZHG4; -.
DR   SMR; Q4ZHG4; -.
DR   BioGRID; 124154; 23.
DR   STRING; 9606.ENSP00000297267; -.
DR   GlyCosmos; Q4ZHG4; 3 sites, 1 glycan.
DR   GlyGen; Q4ZHG4; 18 sites, 3 O-linked glycans (16 sites).
DR   iPTMnet; Q4ZHG4; -.
DR   PhosphoSitePlus; Q4ZHG4; -.
DR   BioMuta; FNDC1; -.
DR   DMDM; 298286926; -.
DR   jPOST; Q4ZHG4; -.
DR   MassIVE; Q4ZHG4; -.
DR   PaxDb; 9606-ENSP00000297267; -.
DR   PeptideAtlas; Q4ZHG4; -.
DR   ProteomicsDB; 62382; -. [Q4ZHG4-1]
DR   ProteomicsDB; 62383; -. [Q4ZHG4-2]
DR   Antibodypedia; 50561; 47 antibodies from 10 providers.
DR   DNASU; 84624; -.
DR   Ensembl; ENST00000297267.14; ENSP00000297267.9; ENSG00000164694.17. [Q4ZHG4-1]
DR   GeneID; 84624; -.
DR   KEGG; hsa:84624; -.
DR   MANE-Select; ENST00000297267.14; ENSP00000297267.9; NM_032532.3; NP_115921.2.
DR   UCSC; uc010kjv.4; human. [Q4ZHG4-1]
DR   AGR; HGNC:21184; -.
DR   CTD; 84624; -.
DR   DisGeNET; 84624; -.
DR   GeneCards; FNDC1; -.
DR   HGNC; HGNC:21184; FNDC1.
DR   HPA; ENSG00000164694; Tissue enhanced (gallbladder, intestine, thyroid gland).
DR   MIM; 609991; gene.
DR   neXtProt; NX_Q4ZHG4; -.
DR   OpenTargets; ENSG00000164694; -.
DR   PharmGKB; PA134906656; -.
DR   VEuPathDB; HostDB:ENSG00000164694; -.
DR   eggNOG; KOG4221; Eukaryota.
DR   GeneTree; ENSGT00530000063558; -.
DR   HOGENOM; CLU_002998_0_0_1; -.
DR   InParanoid; Q4ZHG4; -.
DR   OMA; QIGFGTP; -.
DR   OrthoDB; 4212752at2759; -.
DR   PhylomeDB; Q4ZHG4; -.
DR   TreeFam; TF337588; -.
DR   PathwayCommons; Q4ZHG4; -.
DR   BioGRID-ORCS; 84624; 12 hits in 1139 CRISPR screens.
DR   ChiTaRS; FNDC1; human.
DR   GenomeRNAi; 84624; -.
DR   Pharos; Q4ZHG4; Tbio.
DR   PRO; PR:Q4ZHG4; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q4ZHG4; Protein.
DR   Bgee; ENSG00000164694; Expressed in tendon of biceps brachii and 131 other cell types or tissues.
DR   ExpressionAtlas; Q4ZHG4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   CDD; cd00063; FN3; 5.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR049109; TARSH/FNDC1_C.
DR   PANTHER; PTHR23197:SF8; FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23197; TARSH-RELATED FIBRONECTIN DOMAIN-CONTAINING; 1.
DR   Pfam; PF00041; fn3; 4.
DR   Pfam; PF21731; TARSH_C; 1.
DR   SMART; SM00060; FN3; 5.
DR   SUPFAM; SSF49265; Fibronectin type III; 3.
DR   PROSITE; PS50853; FN3; 5.
DR   Genevisible; Q4ZHG4; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Phosphoprotein; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..1894
FT                   /note="Fibronectin type III domain-containing protein 1"
FT                   /id="PRO_0000284831"
FT   DOMAIN          39..131
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          158..258
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          262..357
FT                   /note="Fibronectin type-III 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          362..457
FT                   /note="Fibronectin type-III 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          1658..1752
FT                   /note="Fibronectin type-III 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          455..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..1271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1311..1350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1444..1515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..641
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..683
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..782
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        784..800
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        861..887
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        904..928
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        932..971
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1000..1014
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1015..1074
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1239..1253
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1444..1505
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         717
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q2Q0I9"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1661
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         394..457
FT                   /note="EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGP
FT                   HSKAFIVAMPTT -> A (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11347906,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_024663"
FT   VARIANT         438
FT                   /note="T -> A (in dbSNP:rs509648)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031826"
FT   VARIANT         463
FT                   /note="E -> Q (in dbSNP:rs420137)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031827"
FT   VARIANT         1003
FT                   /note="Q -> E (in dbSNP:rs370434)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031828"
FT   VARIANT         1180
FT                   /note="D -> E (in dbSNP:rs420054)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031829"
FT   VARIANT         1261
FT                   /note="L -> P (in dbSNP:rs3003174)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT                   /id="VAR_031830"
FT   VARIANT         1280
FT                   /note="Q -> R (in dbSNP:rs2501176)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT                   /id="VAR_031831"
FT   VARIANT         1479..1484
FT                   /note="Missing (in dbSNP:rs3842694)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16098131,
FT                   ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:9704633"
FT                   /id="VAR_063225"
FT   VARIANT         1504
FT                   /note="T -> K (in dbSNP:rs386360)"
FT                   /evidence="ECO:0000269|PubMed:11347906,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16098131,
FT                   ECO:0000269|PubMed:17974005, ECO:0000269|PubMed:9704633"
FT                   /id="VAR_031832"
FT   VARIANT         1574
FT                   /note="T -> A (in dbSNP:rs7763726)"
FT                   /id="VAR_031833"
FT   CONFLICT        36
FT                   /note="S -> P (in Ref. 1; AAY26234)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        122
FT                   /note="P -> S (in Ref. 4; AAI50608)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1295
FT                   /note="M -> K (in Ref. 6; CAE51894)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1487
FT                   /note="P -> S (in Ref. 6; CAE51894)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1685
FT                   /note="D -> N (in Ref. 6; CAE51894)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1894
FT                   /note="W -> G (in Ref. 6; CAE51894)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1894 AA;  205558 MW;  7A0A9D0445E511D8 CRC64;
     MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD
     PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS
     RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP
     RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR
     SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR
     YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT
     TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA
     LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP
     SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI
     TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP
     GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK
     GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS
     PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG
     AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG
     PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ
     PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT
     EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ
     SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD
     DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR
     PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDD EEEDAGFFKG GKEDLLSSSV
     PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR
     LPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY
     RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP
     LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI
     KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTTR RTTTRRPTTT VRTTTRTTTT
     TTPTPTTPIP TCPPGTLERH DDDGNLIMSS NGIPECYAEE DEFSGLETDT AVPTEEAYVI
     YDEDYEFETS RPPTTTEPST TATTPRVIPE EGAISSFPEE EFDLAGRKRF VAPYVTYLNK
     DPSAPCSLTD ALDHFQVDSL DEIIPNDLKK SDLPPQHAPR NITVVAVEGC HSFVIVDWDK
     ATPGDVVTGY LVYSASYEDF IRNKWSTQAS SVTHLPIENL KPNTRYYFKV QAQNPHGYGP
     ISPSVSFVTE SDNPLLVVRP PGGEPIWIPF AFKHDPSYTD CHGRQYVKRT WYRKFVGVVL
     CNSLRYKIYL SDNLKDTFYS IGDSWGRGED HCQFVDSHLD GRTGPQSYVE ALPTIQGYYR
     QYRQEPVRFG NIGFGTPYYY VGWYECGVSI PGKW
//