{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q4WUQ8","uniProtkbId":"CIPC_ASPFU","entryAudit":{"firstPublicDate":"2026-01-28","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-07-05","entryVersion":80,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)","commonName":"Neosartorya fumigata","taxonId":330879,"lineage":["Eukaryota","Fungi","Dikarya","Ascomycota","Pezizomycotina","Eurotiomycetes","Eurotiomycetidae","Eurotiales","Aspergillaceae","Aspergillus","Fumigati"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19486301"}],"value":"Virulence factor cipC"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19486301"}],"value":"CipC-like antibiotic response protein"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"19486301"}],"value":"cipC"},"orfNames":[{"value":"AFUA_5G09330"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19486301"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28120495"}],"value":"Hyphal-specific virulence factor that enables an invasive growth during infection"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28120495"}],"value":"Monomer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19486301"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19486301"}],"value":"Exclusively expressed in the hyphal morphotype"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19486301"}],"value":"Differentially expressed during germination (PubMed:19486301). Not induced by concanamycin A or other kinds of stress (PubMed:19486301)"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28120495"}],"value":"Leads to attenuated virulence in a low-dose murine infection model"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the fungal cipC family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Virulence factor cipC","featureId":"PRO_0000463393"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":130,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0843","category":"Biological process","name":"Virulence"}],"references":[{"referenceNumber":1,"citation":{"id":"16372009","citationType":"journal article","authors":["Nierman W.C.","Pain A.","Anderson M.J.","Wortman J.R.","Kim H.S.","Arroyo J.","Berriman M.","Abe K.","Archer D.B.","Bermejo C.","Bennett J.W.","Bowyer P.","Chen D.","Collins M.","Coulsen R.","Davies R.","Dyer P.S.","Farman M.L.","Fedorova N.","Fedorova N.D.","Feldblyum T.V.","Fischer R.","Fosker N.","Fraser A.","Garcia J.L.","Garcia M.J.","Goble A.","Goldman G.H.","Gomi K.","Griffith-Jones S.","Gwilliam R.","Haas B.J.","Haas H.","Harris D.E.","Horiuchi H.","Huang J.","Humphray S.","Jimenez J.","Keller N.","Khouri H.","Kitamoto K.","Kobayashi T.","Konzack S.","Kulkarni R.","Kumagai T.","Lafton A.","Latge J.-P.","Li W.","Lord A.","Lu C.","Majoros W.H.","May G.S.","Miller B.L.","Mohamoud Y.","Molina M.","Monod M.","Mouyna I.","Mulligan S.","Murphy L.D.","O'Neil S.","Paulsen I.","Penalva M.A.","Pertea M.","Price C.","Pritchard B.L.","Quail M.A.","Rabbinowitsch E.","Rawlins N.","Rajandream M.A.","Reichard U.","Renauld H.","Robson G.D.","Rodriguez de Cordoba S.","Rodriguez-Pena J.M.","Ronning C.M.","Rutter S.","Salzberg S.L.","Sanchez M.","Sanchez-Ferrero J.C.","Saunders D.","Seeger K.","Squares R.","Squares S.","Takeuchi M.","Tekaia F.","Turner G.","Vazquez de Aldana C.R.","Weidman J.","White O.","Woodward J.R.","Yu J.-H.","Fraser C.M.","Galagan J.E.","Asai K.","Machida M.","Hall N.","Barrell B.G.","Denning D.W."],"citationCrossReferences":[{"database":"PubMed","id":"16372009"},{"database":"DOI","id":"10.1038/nature04332"}],"title":"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.","publicationDate":"2005","journal":"Nature","firstPage":"1151","lastPage":"1156","volume":"438"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"19486301","citationType":"journal article","authors":["Bauer B.","Schwienbacher M.","Broniszewska M.","Israel L.","Heesemann J.","Ebel F."],"citationCrossReferences":[{"database":"PubMed","id":"19486301"},{"database":"DOI","id":"10.1111/j.1439-0507.2009.01718.x"}],"title":"Characterisation of the CipC-like protein AFUA_5G09330 of the opportunistic human pathogenic mould Aspergillus fumigatus.","publicationDate":"2010","journal":"Mycoses","firstPage":"296","lastPage":"304","volume":"53"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","INDUCTION","SUBCELLULAR LOCATION","SUBUNIT"]},{"referenceNumber":3,"citation":{"id":"28120495","citationType":"journal article","authors":["Canela H.M.","Takami L.A.","da Silva Ferreira M.E."],"citationCrossReferences":[{"database":"PubMed","id":"28120495"},{"database":"DOI","id":"10.1111/apm.12648"}],"title":"cipC is important for Aspergillus fumigatus virulence.","publicationDate":"2017","journal":"APMIS","firstPage":"141","lastPage":"147","volume":"125"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AAHF01000003","properties":[{"key":"ProteinId","value":"EAL91668.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"XP_753706.1","properties":[{"key":"NucleotideSequenceId","value":"XM_748613.1"}]},{"database":"AlphaFoldDB","id":"Q4WUQ8","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"330879.Q4WUQ8","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblFungi","id":"Afu5g09330-T","properties":[{"key":"ProteinId","value":"Afu5g09330-T-p1"},{"key":"GeneId","value":"Afu5g09330"}]},{"database":"GeneID","id":"3511048","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"afm:AFUA_5G09330","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"FungiDB:Afu5g09330","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S76S","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_143683_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q4WUQ8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MAWGWEQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9895617at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000002530","properties":[{"key":"Component","value":"Chromosome 5"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:AspGD"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19486301"}]},{"database":"InterPro","id":"IPR022234","properties":[{"key":"EntryName","value":"CipC-like"}]},{"database":"PANTHER","id":"PTHR37450","properties":[{"key":"EntryName","value":"CIPC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR37450:SF1","properties":[{"key":"EntryName","value":"CIPC PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12585","properties":[{"key":"EntryName","value":"DUF3759"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAWGWEQSDEAHREVYGERRHESSLSHELIAGAASFAGMKAWEDHQRKEGKPVSHAFAKEALAGFVGAEVDKLIETKGLDEADKIRARRHAKENAERMYDEHYVDRHGAPEYDPGRYPPHERFDRPVDRW","length":130,"molWeight":15053,"crc64":"2643EAC0DEFDA467","md5":"9A3DB6EE0705931AD46B5B2B90CB56D5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":1},"uniParcId":"UPI000051F735"}}