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With the RNA-binding protein (RBP) csdA, forms a post-transcriptional control network for secondary metabolites biosynthesis, csdA controlling the expression of laeB at the post-transcriptional level by influencing the alternative splicing of its pre-mRNA (PubMed:41498629). Once translated, the laeB protein is able to interact with csdA to form a regulatory complex to regulate the growth, development, and metabolism (PubMed:41498629). CsdA and laeB both regulate the expression of multiple transcription factors associated with secondary metabolism, including the stress-responsive sebA, calcium-responsive crzA and htfA, pH-responsive pacC, mitochondrial fhdA, copper homeostasis clcA, as well as transcription factors rsmA, zfpA, zfpB, and ace2 (PubMed:41498629). Thus, they contribute to virulence via regulation of the production of fumiquinazoline C, as well as of diverse additional mycotoxins including gliotoxin, endocrocin, fumihopaside and neosartoricin (PubMed:41498629)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41498629"}],"value":"Interacts with csdA"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41498629"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"W3WX91"}],"value":"The RNA-binding protein csdA mediates laeB expression by binding specific motif GUCGGUAU on laeB pre-mRNA for alternative splicing, regulating the stability of intron 2 splicing, thereby producing normal levels of laeB protein that interacts with csdA to regulate fungal growth, development and secondary metabolism"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41498629"}],"value":"Leads to a more than twofold up-regulation of fumiquinazoline C (FQC) fmqA-E and a 1.6-fold down-regulation of sebA, the negative transcription fator that directly governs this gene cluster, resulting in a 13.35-fold increase of FQC production (PubMed:41498629). Affects also the expression of many transcription factors associated with secondary metabolism or virulence (PubMed:41498629)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the laeB global regulator family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Global regulator 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