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Plays a critical role in ergosterol biosynthesis, resistance to the azole class of antifungal drugs, and in maintenance of cell polarity (PubMed:18989462, PubMed:22006005, PubMed:22144905, PubMed:25107308, PubMed:25375670, PubMed:27438727, PubMed:27934927, PubMed:28052140). Directly binds erg11A/cyp51A upstream DNA sequence at tandem repeats, called TR34 and TR46, that produce duplicated binding sites (PubMed:22006005, PubMed:27934927, PubMed:35467427, PubMed:35575535). Also mediates regulation of iron acquisition in response to hypoxia and low iron conditions via activation of extra- and intracellular siderophore production (PubMed:22144905, PubMed:22260221, PubMed:25375670, PubMed:37093084). Positively regulates the expression of the other hypoxia adaptation key transcription factor srbB (PubMed:25375670). Required for the azole-sensing and response to azole stress (PubMed:28050634). Binds the high-affinity sites 5'-A-T-C-G/A-T/G-A/G-C/T-G/C-A-T-3' of target promoters (PubMed:22260221). Required for virulence in murine models of invasive pulmonary aspergillosis (IPA) (PubMed:18989462)"}],"commentType":"FUNCTION","molecule":"Cleavage-activated transcription regulator srbA"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23104569"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass membrane protein","id":"SL-9904"}}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Cleavage-activated transcription regulator srbA","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23104569"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22144905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25107308"}],"value":"Expression is inducedd under iron starvation conditions and hypoxia"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23104569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27303716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34964293"}],"value":"In low oxygen or sterol conditions, undergoes proteolytic cleavage by rhomboid-type protease rbdB and is released as soluble transcription factor from the membrane"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18989462"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22006005"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22144905"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23104569"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25107308"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27303716"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27934927"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28052140"}],"value":"Impairs growth in a hypoxic environment and subsequent virulence in two distinct murine models of invasive pulmonary aspergillosis (IPA) (PubMed:18989462, PubMed:22006005, PubMed:23104569, PubMed:27303716). Decreases the expression of erg11A/cyp51A in response to fluconazole and voriconazole (PubMed:22006005). Also impairs growth during iron starvation due to iron shortage (PubMed:22144905, PubMed:25107308). Affects the expression of at least 87 genes including genes involved in sterol biosynthesis and hyphal morphology (PubMed:18989462). 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