{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q4QL34","uniProtkbId":"HVFC_HAEI8","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-07-19","entryVersion":69,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Haemophilus influenzae (strain 86-028NP)","taxonId":281310,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Pasteurellales","Pasteurellaceae","Haemophilus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multinuclear nonheme iron-dependent oxidase partner protein HvfC"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38968106"}],"value":"MNIO partner protein HvfC"}]},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38968106"}],"value":"Haemophilus virulence factor C"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"RiPP recognition element-containing partner protein HvfC"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"RRE-containing partner protein HvfC"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"38968106"}],"value":"hvfC"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAX88263.1"}],"value":"NTHI1444"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38968106"}],"value":"Involved in the biosynthesis of the virulence factor peptide HvfA (oxazolin) (PubMed:38968106). Acts as a partner protein of the multinuclear nonheme iron-dependent oxidase (MNIO) HvfB and participates in post-translational modification of HvfA (PubMed:38968106). HvfC may play a role in substrate recognition (PubMed:38968106)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38968106"}],"value":"Forms a weak complex with HvfB (PubMed:38968106). Also interacts with HvfA (PubMed:38968106)"}],"commentType":"SUBUNIT"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38968106"}],"value":"Part of the hvfXABC operon (NTHI1440-NTHI1441-NTHI1443-NTHI1444)"}],"commentType":"INDUCTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Multinuclear nonheme iron-dependent oxidase partner protein HvfC","featureId":"PRO_0000463664"}],"references":[{"referenceNumber":1,"citation":{"id":"15968074","citationType":"journal article","authors":["Harrison A.","Dyer D.W.","Gillaspy A.","Ray W.C.","Mungur R.","Carson M.B.","Zhong H.","Gipson J.","Gipson M.","Johnson L.S.","Lewis L.","Bakaletz L.O.","Munson R.S. 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