{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q4KMQ2","secondaryAccessions":["A6NNM6","B9EGG0","E7ENK4","E9PB30","E9PCT2","Q8N3Q2"],"uniProtkbId":"ANO6_HUMAN","entryAudit":{"firstPublicDate":"2005-09-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-10-17","entryVersion":168,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Anoctamin-6"}},"alternativeNames":[{"fullName":{"value":"Small-conductance calcium-activated nonselective cation channel"},"shortNames":[{"value":"SCAN channel"}]},{"fullName":{"value":"Transmembrane protein 16F"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25240"}],"value":"ANO6"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"33827113"}],"value":"TMEM16F"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20056604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21107324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21908539"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22006324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22946059"}],"value":"Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33827113"}],"value":"(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38663"},{"database":"ChEBI","id":"CHEBI:57262"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38899"},{"database":"ChEBI","id":"CHEBI:18390"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38571"},{"database":"ChEBI","id":"CHEBI:57643"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}],"value":"Exhibits synergistic gating by Ca(2+) and voltage (By similarity). Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity)"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33827113"}],"value":"(Microbial infection) Activated by SARS coronavirus-2/SARS-CoV-2 spike protein"}],"commentType":"ACTIVITY REGULATION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"value":"Shows an intracellular localization according to PubMed:22075693"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20056604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21107324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22075693"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22946059"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20056604"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21107324"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22075693"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"22946059"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q4KMQ2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q4KMQ2-2"],"sequenceIds":["VSP_042893"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q4KMQ2-3"],"sequenceIds":["VSP_046819"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q4KMQ2-4"],"sequenceIds":["VSP_046820"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15067359"}],"value":"Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33827113"}],"value":"(Microbial infection) Expression is induced by SARS coronavirus-2/SARS-CoV-2 spike protein"}],"commentType":"INDUCTION"},{"commentType":"DISEASE","disease":{"diseaseId":"Scott syndrome","diseaseAccession":"DI-03017","acronym":"SCTS","description":"A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents.","diseaseCrossReference":{"database":"MIM","id":"262890"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21107324"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the anoctamin family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}],"value":"Contains ten transmembrane regions, not eight as predicted"}],"commentType":"CAUTION"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"Anoctamin-6","featureId":"PRO_0000191757"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":300,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":301,"modifier":"EXACT"},"end":{"value":321,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":375,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":376,"modifier":"EXACT"},"end":{"value":396,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":455,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":456,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":509,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":510,"modifier":"EXACT"},"end":{"value":530,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":531,"modifier":"EXACT"},"end":{"value":551,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":552,"modifier":"EXACT"},"end":{"value":572,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":573,"modifier":"EXACT"},"end":{"value":601,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":602,"modifier":"EXACT"},"end":{"value":621,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":622,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":664,"modifier":"EXACT"},"end":{"value":684,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Transmembrane","location":{"start":{"value":685,"modifier":"EXACT"},"end":{"value":705,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":706,"modifier":"EXACT"},"end":{"value":722,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":723,"modifier":"EXACT"},"end":{"value":743,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":744,"modifier":"EXACT"},"end":{"value":836,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":857,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Topological domain","location":{"start":{"value":858,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Binding site","location":{"start":{"value":623,"modifier":"EXACT"},"end":{"value":623,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":666,"modifier":"EXACT"},"end":{"value":666,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Binding site","location":{"start":{"value":669,"modifier":"EXACT"},"end":{"value":669,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}],"ligand":{"name":"Ca(2+)","id":"ChEBI:CHEBI:29108"}},{"type":"Glycosylation","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":361,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19159218"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":777,"modifier":"EXACT"},"end":{"value":777,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":790,"modifier":"EXACT"},"end":{"value":790,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":802,"modifier":"EXACT"},"end":{"value":802,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":330,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Disulfide bond","location":{"start":{"value":337,"modifier":"EXACT"},"end":{"value":364,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Disulfide bond","location":{"start":{"value":348,"modifier":"EXACT"},"end":{"value":806,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Disulfide bond","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Disulfide bond","location":{"start":{"value":595,"modifier":"EXACT"},"end":{"value":600,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6P9J9"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_046819","alternativeSequence":{"originalSequence":"MKKMSRNVLLQMEEEEDDDDGDI","alternativeSequences":["MFCAA"]}},{"type":"Alternative sequence","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_042893","alternativeSequence":{"originalSequence":"I","alternativeSequences":["IGDVPASRRPFLTPHTHLPSSL"]}},{"type":"Alternative sequence","location":{"start":{"value":843,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_046820","alternativeSequence":{"originalSequence":"HVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE","alternativeSequences":["YLALLPRLGHSGMILAHCNLRLPVDCCMCYRFVDEIRLLEQLTSDFIDSLYYIFSISIISIFFSVTFFFLLLSLGPTPCFSVSNFLS"]}},{"type":"Natural variant","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":128,"modifier":"EXACT"}},"description":"in dbSNP:rs2162321","featureCrossReferences":[{"database":"dbSNP","id":"rs2162321"}],"featureId":"VAR_028109","alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":837,"modifier":"EXACT"},"end":{"value":837,"modifier":"EXACT"}},"description":"in Ref. 2; AAH98410","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0868","category":"Ligand","name":"Chloride"},{"id":"KW-0869","category":"Molecular function","name":"Chloride channel"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0945","category":"Biological process","name":"Host-virus interaction"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0445","category":"Biological process","name":"Lipid transport"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"},{"id":"KW-0851","category":"Molecular function","name":"Voltage-gated channel"}],"references":[{"referenceNumber":1,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Placenta","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 772-910 (ISOFORM 1/2)"],"referenceComments":[{"value":"Adipose tissue","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15067359","citationType":"journal article","authors":["Katoh M.","Katoh M."],"citationCrossReferences":[{"database":"PubMed","id":"15067359"},{"database":"DOI","id":"10.3892/ijo.24.5.1345"}],"title":"Identification and characterization of TMEM16E and TMEM16F genes in silico.","publicationDate":"2004","journal":"Int. J. Oncol.","firstPage":"1345","lastPage":"1349","volume":"24"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":5,"citation":{"id":"19159218","citationType":"journal article","authors":["Chen R.","Jiang X.","Sun D.","Han G.","Wang F.","Ye M.","Wang L.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"19159218"},{"database":"DOI","id":"10.1021/pr8008012"}],"title":"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.","publicationDate":"2009","journal":"J. Proteome Res.","firstPage":"651","lastPage":"661","volume":"8"},"referencePositions":["GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-493"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"20056604","citationType":"journal article","authors":["Schreiber R.","Uliyakina I.","Kongsuphol P.","Warth R.","Mirza M.","Martins J.R.","Kunzelmann K."],"citationCrossReferences":[{"database":"PubMed","id":"20056604"},{"database":"DOI","id":"10.1074/jbc.m109.065367"}],"title":"Expression and function of epithelial anoctamins.","publicationDate":"2010","journal":"J. Biol. Chem.","firstPage":"7838","lastPage":"7845","volume":"285"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":7,"citation":{"id":"21107324","citationType":"journal article","authors":["Suzuki J.","Umeda M.","Sims P.J.","Nagata S."],"citationCrossReferences":[{"database":"PubMed","id":"21107324"},{"database":"DOI","id":"10.1038/nature09583"}],"title":"Calcium-dependent phospholipid scrambling by TMEM16F.","publicationDate":"2010","journal":"Nature","firstPage":"834","lastPage":"838","volume":"468"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INVOLVEMENT IN SCOTT SYNDROME"]},{"referenceNumber":8,"citation":{"id":"21642943","citationType":"journal article","authors":["Duran C.","Hartzell H.C."],"citationCrossReferences":[{"database":"PubMed","id":"21642943"},{"database":"DOI","id":"10.1038/aps.2011.48"}],"title":"Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?","publicationDate":"2011","journal":"Acta Pharmacol. Sin.","firstPage":"685","lastPage":"692","volume":"32"},"referencePositions":["REVIEW"]},{"referenceNumber":9,"citation":{"id":"21607626","citationType":"journal article","authors":["Kunzelmann K.","Tian Y.","Martins J.R.","Faria D.","Kongsuphol P.","Ousingsawat J.","Thevenod F.","Roussa E.","Rock J.","Schreiber R."],"citationCrossReferences":[{"database":"PubMed","id":"21607626"},{"database":"DOI","id":"10.1007/s00424-011-0975-9"}],"title":"Anoctamins.","publicationDate":"2011","journal":"Pflugers Arch.","firstPage":"195","lastPage":"208","volume":"462"},"referencePositions":["REVIEW"]},{"referenceNumber":10,"citation":{"id":"22006324","citationType":"journal article","authors":["Martins J.R.","Faria D.","Kongsuphol P.","Reisch B.","Schreiber R.","Kunzelmann K."],"citationCrossReferences":[{"database":"PubMed","id":"22006324"},{"database":"DOI","id":"10.1073/pnas.1108094108"}],"title":"Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"18168","lastPage":"18172","volume":"108"},"referencePositions":["FUNCTION"]},{"referenceNumber":11,"citation":{"id":"22075693","citationType":"journal article","authors":["Duran C.","Qu Z.","Osunkoya A.O.","Cui Y.","Hartzell H.C."],"citationCrossReferences":[{"database":"PubMed","id":"22075693"},{"database":"DOI","id":"10.1152/ajpcell.00140.2011"}],"title":"ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins.","publicationDate":"2012","journal":"Am. J. Physiol.","firstPage":"C482","lastPage":"C493","volume":"302"},"referencePositions":["SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"22302790","citationType":"journal article","authors":["Winpenny J.P.","Gray M.A."],"citationCrossReferences":[{"database":"PubMed","id":"22302790"},{"database":"DOI","id":"10.1113/expphysiol.2011.058214"}],"title":"The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age.","publicationDate":"2012","journal":"Exp. Physiol.","firstPage":"175","lastPage":"176","volume":"97"},"referencePositions":["REVIEW"]},{"referenceNumber":13,"citation":{"id":"21984732","citationType":"journal article","authors":["Scudieri P.","Sondo E.","Ferrera L.","Galietta L.J."],"citationCrossReferences":[{"database":"PubMed","id":"21984732"},{"database":"DOI","id":"10.1113/expphysiol.2011.058198"}],"title":"The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.","publicationDate":"2012","journal":"Exp. Physiol.","firstPage":"177","lastPage":"183","volume":"97"},"referencePositions":["REVIEW","ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY"]},{"referenceNumber":14,"citation":{"id":"21908539","citationType":"journal article","authors":["Kunzelmann K.","Schreiber R.","Kmit A.","Jantarajit W.","Martins J.R.","Faria D.","Kongsuphol P.","Ousingsawat J.","Tian Y."],"citationCrossReferences":[{"database":"PubMed","id":"21908539"},{"database":"DOI","id":"10.1113/expphysiol.2011.058206"}],"title":"Expression and function of epithelial anoctamins.","publicationDate":"2012","journal":"Exp. Physiol.","firstPage":"184","lastPage":"192","volume":"97"},"referencePositions":["REVIEW","FUNCTION"]},{"referenceNumber":15,"citation":{"id":"22946059","citationType":"journal article","authors":["Tian Y.","Schreiber R.","Kunzelmann K."],"citationCrossReferences":[{"database":"PubMed","id":"22946059"},{"database":"DOI","id":"10.1242/jcs.109553"}],"title":"Anoctamins are a family of Ca2+ activated Cl- channels.","publicationDate":"2012","journal":"J. Cell Sci.","firstPage":"4991","lastPage":"4998","volume":"125"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]},{"referenceNumber":16,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":17,"citation":{"id":"25944712","citationType":"journal article","authors":["Vaca Jacome A.S.","Rabilloud T.","Schaeffer-Reiss C.","Rompais M.","Ayoub D.","Lane L.","Bairoch A.","Van Dorsselaer A.","Carapito C."],"citationCrossReferences":[{"database":"PubMed","id":"25944712"},{"database":"DOI","id":"10.1002/pmic.201400617"}],"title":"N-terminome analysis of the human mitochondrial proteome.","publicationDate":"2015","journal":"Proteomics","firstPage":"2519","lastPage":"2524","volume":"15"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"33827113","citationType":"journal article","authors":["Braga L.","Ali H.","Secco I.","Chiavacci E.","Neves G.","Goldhill D.","Penn R.","Jimenez-Guardeno J.M.","Ortega-Prieto A.M.","Bussani R.","Cannata A.","Rizzari G.","Collesi C.","Schneider E.","Arosio D.","Shah A.M.","Barclay W.S.","Malim M.H.","Burrone J.","Giacca M."],"citationCrossReferences":[{"database":"PubMed","id":"33827113"},{"database":"DOI","id":"10.1038/s41586-021-03491-6"}],"title":"Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia.","publicationDate":"2021","journal":"Nature","firstPage":"88","lastPage":"93","volume":"594"},"referencePositions":["FUNCTION (MICROBIAL INFECTION)","INDUCTION BY SARS-COV-2 INFECTION (MICROBIAL INFECTION)"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC009248","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC009778","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC063924","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC098410","properties":[{"key":"ProteinId","value":"AAH98410.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC136445","properties":[{"key":"ProteinId","value":"AAI36446.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL833405","properties":[{"key":"ProteinId","value":"CAD38638.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS31782.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q4KMQ2-1"},{"database":"CCDS","id":"CCDS44865.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q4KMQ2-4"},{"database":"CCDS","id":"CCDS44866.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q4KMQ2-3"},{"database":"CCDS","id":"CCDS55819.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q4KMQ2-2"},{"database":"RefSeq","id":"NP_001020527.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001025356.3"}],"isoformId":"Q4KMQ2-1"},{"database":"RefSeq","id":"NP_001136150.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001142678.2"}],"isoformId":"Q4KMQ2-3"},{"database":"RefSeq","id":"NP_001136151.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001142679.2"}],"isoformId":"Q4KMQ2-4"},{"database":"RefSeq","id":"NP_001191732.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001204803.2"}],"isoformId":"Q4KMQ2-2"},{"database":"AlphaFoldDB","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"128218","properties":[{"key":"Interactions","value":"150"}]},{"database":"FunCoup","id":"Q4KMQ2","properties":[{"key":"Number of interactors","value":"638"}]},{"database":"IntAct","id":"Q4KMQ2","properties":[{"key":"Interactions","value":"87"}]},{"database":"MINT","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-ANO6","properties":[{"key":"Evidences","value":"2 NDEx IQuery Curated Pathways"}]},{"database":"STRING","id":"9606.ENSP00000409126","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.17.1.4","properties":[{"key":"FamilyName","value":"the calcium-dependent chloride channel (ca-clc) family"}]},{"database":"GlyConnect","id":"Q4KMQ2","properties":[{"key":"glycosylation","value":"7 N-Linked glycans (2 sites)"}]},{"database":"GlyCosmos","id":"Q4KMQ2","properties":[{"key":"glycosylation","value":"6 sites, 7 glycans"}]},{"database":"GlyGen","id":"Q4KMQ2","properties":[{"key":"glycosylation","value":"8 sites, 19 N-linked glycans (6 sites), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"ANO6","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"116242820","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000409126","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19131","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19507","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"62203","properties":[{"key":"Description","value":"-"}],"isoformId":"Q4KMQ2-1"},{"database":"ProteomicsDB","id":"62204","properties":[{"key":"Description","value":"-"}],"isoformId":"Q4KMQ2-2"},{"database":"Pumba","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"ABCD","id":"Q4KMQ2","properties":[{"key":"antibodies","value":"11 sequenced antibodies"}]},{"database":"Antibodypedia","id":"42608","properties":[{"key":"antibodies","value":"134 antibodies from 23 providers"}]},{"database":"DNASU","id":"196527","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000320560.13","properties":[{"key":"ProteinId","value":"ENSP00000320087.8"},{"key":"GeneId","value":"ENSG00000177119.18"}],"isoformId":"Q4KMQ2-1"},{"database":"Ensembl","id":"ENST00000423947.7","properties":[{"key":"ProteinId","value":"ENSP00000409126.3"},{"key":"GeneId","value":"ENSG00000177119.18"}],"isoformId":"Q4KMQ2-2"},{"database":"Ensembl","id":"ENST00000425752.6","properties":[{"key":"ProteinId","value":"ENSP00000391417.2"},{"key":"GeneId","value":"ENSG00000177119.18"}],"isoformId":"Q4KMQ2-4"},{"database":"Ensembl","id":"ENST00000441606.2","properties":[{"key":"ProteinId","value":"ENSP00000413137.2"},{"key":"GeneId","value":"ENSG00000177119.18"}],"isoformId":"Q4KMQ2-3"},{"database":"Ensembl","id":"ENST00000680201.1","properties":[{"key":"ProteinId","value":"ENSP00000506222.1"},{"key":"GeneId","value":"ENSG00000177119.18"}],"isoformId":"Q4KMQ2-1"},{"database":"GeneID","id":"196527","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:196527","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000320560.13","properties":[{"key":"ProteinId","value":"ENSP00000320087.8"},{"key":"RefSeqNucleotideId","value":"NM_001025356.3"},{"key":"RefSeqProteinId","value":"NP_001020527.2"}]},{"database":"UCSC","id":"uc001roo.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q4KMQ2-1"},{"database":"AGR","id":"HGNC:25240","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA164715690","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"196527","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"196527","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"ANO6","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25240","properties":[{"key":"GeneName","value":"ANO6"}]},{"database":"HPA","id":"ENSG00000177119","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"ANO6","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"262890","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"608663","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000177119","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"806","properties":[{"key":"Disease","value":"Scott syndrome"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000177119","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2514","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000158969","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_006685_1_3_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PYAVREQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"296386at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q4KMQ2","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-2672351","properties":[{"key":"PathwayName","value":"Stimuli-sensing channels"}]},{"database":"Reactome","id":"R-HSA-6798695","properties":[{"key":"PathwayName","value":"Neutrophil degranulation"}]},{"database":"Reactome","id":"R-HSA-9733458","properties":[{"key":"PathwayName","value":"Induction of Cell-Cell Fusion"}]},{"database":"Reactome","id":"R-HSA-9769739","properties":[{"key":"PathwayName","value":"Regulation of clotting cascade"}]},{"database":"Reactome","id":"R-HSA-9769743","properties":[{"key":"PathwayName","value":"Amplification and propagation of coagulation cascade"}]},{"database":"Reactome","id":"R-HSA-9853846","properties":[{"key":"PathwayName","value":"Defective ANO6 does not expose PS, PE on the platelet membrane"}]},{"database":"SignaLink","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000177119","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"196527","properties":[{"key":"hits","value":"14 hits in 1165 CRISPR screens"}]},{"database":"ChiTaRS","id":"ANO6","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"196527","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q4KMQ2","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q4KMQ2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"Q4KMQ2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000177119","properties":[{"key":"ExpressionPatterns","value":"Expressed in epithelial cell of pancreas and 192 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q4KMQ2","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009986","properties":[{"key":"GoTerm","value":"C:cell surface"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19581412"}]},{"database":"GO","id":"GO:0034707","properties":[{"key":"GoTerm","value":"C:chloride channel complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22006324"}]},{"database":"GO","id":"GO:0098981","properties":[{"key":"GoTerm","value":"C:cholinergic synapse"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070062","properties":[{"key":"GoTerm","value":"C:extracellular exosome"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19056867"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19199708"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"20458337"},{"evidenceCode":"ECO:0007005","source":"PubMed","id":"23533145"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"HDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"19946888"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"21107324"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22946059"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0035579","properties":[{"key":"GoTerm","value":"C:specific granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0097060","properties":[{"key":"GoTerm","value":"C:synaptic membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0070821","properties":[{"key":"GoTerm","value":"C:tertiary granule membrane"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005227","properties":[{"key":"GoTerm","value":"F:calcium-activated cation channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"22946059"}]},{"database":"GO","id":"GO:0005254","properties":[{"key":"GoTerm","value":"F:chloride channel activity"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005229","properties":[{"key":"GoTerm","value":"F:intracellularly calcium-gated chloride channel activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22946059"}]},{"database":"GO","id":"GO:0017128","properties":[{"key":"GoTerm","value":"F:phospholipid scramblase activity"},{"key":"GoEvidenceType","value":"IMP:FlyBase"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"30700552"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0005247","properties":[{"key":"GoTerm","value":"F:voltage-gated chloride channel activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22006324"}]},{"database":"GO","id":"GO:0005244","properties":[{"key":"GoTerm","value":"F:voltage-gated monoatomic ion channel activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002543","properties":[{"key":"GoTerm","value":"P:activation of blood coagulation via clotting cascade"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21107324"}]},{"database":"GO","id":"GO:0032060","properties":[{"key":"GoTerm","value":"P:bleb assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0007596","properties":[{"key":"GoTerm","value":"P:blood coagulation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061590","properties":[{"key":"GoTerm","value":"P:calcium activated phosphatidylcholine scrambling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0061589","properties":[{"key":"GoTerm","value":"P:calcium activated phosphatidylserine scrambling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070588","properties":[{"key":"GoTerm","value":"P:calcium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"25589784"}]},{"database":"GO","id":"GO:1902476","properties":[{"key":"GoTerm","value":"P:chloride transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22006324"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"22946059"}]},{"database":"GO","id":"GO:0034220","properties":[{"key":"GoTerm","value":"P:monoatomic ion transmembrane transport"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0045794","properties":[{"key":"GoTerm","value":"P:negative regulation of cell volume"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0097045","properties":[{"key":"GoTerm","value":"P:phosphatidylserine exposure on blood platelet"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21107324"}]},{"database":"GO","id":"GO:0017121","properties":[{"key":"GoTerm","value":"P:plasma membrane phospholipid scrambling"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0046931","properties":[{"key":"GoTerm","value":"P:pore complex assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030501","properties":[{"key":"GoTerm","value":"P:positive regulation of bone mineralization"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25589784"}]},{"database":"GO","id":"GO:0034767","properties":[{"key":"GoTerm","value":"P:positive regulation of monoatomic ion transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0090026","properties":[{"key":"GoTerm","value":"P:positive regulation of monocyte chemotaxis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0060100","properties":[{"key":"GoTerm","value":"P:positive regulation of phagocytosis, engulfment"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1903766","properties":[{"key":"GoTerm","value":"P:positive regulation of potassium ion export across plasma membrane"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035590","properties":[{"key":"GoTerm","value":"P:purinergic nucleotide receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25651887"}]},{"database":"GO","id":"GO:0060078","properties":[{"key":"GoTerm","value":"P:regulation of postsynaptic membrane potential"},{"key":"GoEvidenceType","value":"IEA:Ensembl"}]},{"database":"GO","id":"GO:0035725","properties":[{"key":"GoTerm","value":"P:sodium ion transmembrane transport"},{"key":"GoEvidenceType","value":"IGI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"25589784"}]},{"database":"InterPro","id":"IPR032394","properties":[{"key":"EntryName","value":"Anoct_dimer"}]},{"database":"InterPro","id":"IPR007632","properties":[{"key":"EntryName","value":"Anoctamin"}]},{"database":"InterPro","id":"IPR049452","properties":[{"key":"EntryName","value":"Anoctamin_TM"}]},{"database":"PANTHER","id":"PTHR12308","properties":[{"key":"EntryName","value":"ANOCTAMIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12308:SF21","properties":[{"key":"EntryName","value":"ANOCTAMIN-6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16178","properties":[{"key":"EntryName","value":"Anoct_dimer"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04547","properties":[{"key":"EntryName","value":"Anoctamin"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE","length":910,"molWeight":106165,"crc64":"8F7F1CB78FAAEB78","md5":"FA878AB0890089979B34A29F7E1F18CF"},"extraAttributes":{"countByCommentType":{"FUNCTION":2,"CATALYTIC ACTIVITY":3,"ACTIVITY REGULATION":2,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DISEASE":1,"MISCELLANEOUS":1,"SIMILARITY":1,"CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":10,"Transmembrane":10,"Binding site":3,"Glycosylation":6,"Disulfide bond":5,"Alternative sequence":3,"Natural variant":1,"Sequence conflict":1},"uniParcId":"UPI0000229358"}}