{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q497N7","secondaryAccessions":["Q9D433","Q9D460"],"uniProtkbId":"TEX56_MOUSE","entryAudit":{"firstPublicDate":"2007-08-21","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2005-09-13","entryVersion":88,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Testis expressed protein 56"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1914011"}],"value":"Tex56"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27357688"}],"value":"Expressed predominantly in the testis"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27357688"}],"value":"Deficient mice are viable and have normal fertility"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAB30424.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAB30456.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Testis expressed protein 56","featureId":"PRO_0000297589"},{"type":"Sequence conflict","location":{"start":{"value":102,"modifier":"EXACT"},"end":{"value":102,"modifier":"EXACT"}},"description":"in Ref. 1; BAB30456","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in Ref. 1; BAB30424","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in Ref. 1; BAB30456","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"27357688","citationType":"journal article","authors":["Miyata H.","Castaneda J.M.","Fujihara Y.","Yu Z.","Archambeault D.R.","Isotani A.","Kiyozumi D.","Kriseman M.L.","Mashiko D.","Matsumura T.","Matzuk R.M.","Mori M.","Noda T.","Oji A.","Okabe M.","Prunskaite-Hyyrylainen R.","Ramirez-Solis R.","Satouh Y.","Zhang Q.","Ikawa M.","Matzuk M.M."],"citationCrossReferences":[{"database":"PubMed","id":"27357688"},{"database":"DOI","id":"10.1073/pnas.1608458113"}],"title":"Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.","publicationDate":"2016","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"7704","lastPage":"7710","volume":"113"},"referencePositions":["DISRUPTION PHENOTYPE","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK016778","properties":[{"key":"ProteinId","value":"BAB30424.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK016838","properties":[{"key":"ProteinId","value":"BAB30456.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC100450","properties":[{"key":"ProteinId","value":"AAI00451.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC145747","properties":[{"key":"ProteinId","value":"AAI45748.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS49233.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_080026.2","properties":[{"key":"NucleotideSequenceId","value":"NM_025750.3"}]},{"database":"RefSeq","id":"XP_011242631.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011244329.1"}]},{"database":"AlphaFoldDB","id":"Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000125324","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000125324","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"66761","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000160279.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000125324.2"},{"key":"GeneId","value":"ENSMUSG00000021415.14"}]},{"database":"Ensembl","id":"ENSMUST00000160905.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000125206.2"},{"key":"GeneId","value":"ENSMUSG00000021415.14"}]},{"database":"GeneID","id":"66761","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:66761","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007qbt.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1914011","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"66761","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1914011","properties":[{"key":"GeneName","value":"Tex56"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000021415","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S904","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000008360","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_115219_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FQCAWQQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6077037at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"66761","properties":[{"key":"hits","value":"0 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q497N7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"RNAct","id":"Q497N7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000021415","properties":[{"key":"ExpressionPatterns","value":"Expressed in seminiferous tubule of testis and 8 other cell types or tissues"}]},{"database":"InterPro","id":"IPR027827","properties":[{"key":"EntryName","value":"Tex56"}]},{"database":"PANTHER","id":"PTHR35968","properties":[{"key":"EntryName","value":"CHROMOSOME 6 C6ORF201 HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35968:SF1","properties":[{"key":"EntryName","value":"TESTIS EXPRESSED PROTEIN 56"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15023","properties":[{"key":"EntryName","value":"DUF4523"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDVDIDPEQLFTEKMPKNYAQPDVLNHTFDLLSNLHKLLPNHLVEVLHSYRSEEDKNKCEKPEFSGLEKILARHQLPKEISLSPKPSLMPSWRRRIINNISGNWKKCHLWQKSTYEPPMGTIVARWTKKNLQPTEDLKSVIQRLSALGPIISVTPSGRQSAVVVFRDITSACKAVSAFQSMSGGSMFQCSWQHRFMAKNKTWSRKCTSKVHLEKRESTVGEPQELHN","length":227,"molWeight":26076,"crc64":"9742F668EFFA0FB0","md5":"52004E85813C04CDFE8EF30E3FA73642"},"extraAttributes":{"countByCommentType":{"TISSUE SPECIFICITY":1,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Sequence conflict":3},"uniParcId":"UPI00001E86CB"}}