{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q49626","uniProtkbId":"Y1222_MYCLE","entryAudit":{"firstPublicDate":"2001-08-29","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"1996-11-01","entryVersion":102,"sequenceVersion":1},"annotationScore":1.0,"organism":{"scientificName":"Mycobacterium leprae (strain TN)","taxonId":272631,"lineage":["Bacteria","Bacillati","Actinomycetota","Actinomycetes","Mycobacteriales","Mycobacteriaceae","Mycobacterium"]},"proteinExistence":"4: Predicted","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein ML1222"}}},"genes":[{"orderedLocusNames":[{"value":"ML1222"}],"orfNames":[{"value":"B1170_C3_229"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"To M.tuberculosis Rv1591"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":198,"modifier":"EXACT"}},"description":"Uncharacterized protein ML1222","featureId":"PRO_0000103893"},{"type":"Transmembrane","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":70,"modifier":"EXACT"},"end":{"value":90,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-1C0TOMUTRAJ12","citationType":"submission","authors":["Smith D.R.","Robison K."],"publicationDate":"MAR-1994","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"11234002","citationType":"journal article","authors":["Cole S.T.","Eiglmeier K.","Parkhill J.","James K.D.","Thomson N.R.","Wheeler P.R.","Honore N.","Garnier T.","Churcher C.M.","Harris D.E.","Mungall K.L.","Basham D.","Brown D.","Chillingworth T.","Connor R.","Davies R.M.","Devlin K.","Duthoy S.","Feltwell T.","Fraser A.","Hamlin N.","Holroyd S.","Hornsby T.","Jagels K.","Lacroix C.","Maclean J.","Moule S.","Murphy L.D.","Oliver K.","Quail M.A.","Rajandream M.A.","Rutherford K.M.","Rutter S.","Seeger K.","Simon S.","Simmonds M.","Skelton J.","Squares R.","Squares S.","Stevens K.","Taylor K.","Whitehead S.","Woodward J.R.","Barrell B.G."],"citationCrossReferences":[{"database":"PubMed","id":"11234002"},{"database":"DOI","id":"10.1038/35059006"}],"title":"Massive gene decay in the leprosy bacillus.","publicationDate":"2001","journal":"Nature","firstPage":"1007","lastPage":"1011","volume":"409"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"TN","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"U00010","properties":[{"key":"ProteinId","value":"AAA17073.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL583921","properties":[{"key":"ProteinId","value":"CAC31603.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"S72709","properties":[{"key":"EntryName","value":"S72709"}]},{"database":"RefSeq","id":"WP_010908206.1","properties":[{"key":"NucleotideSequenceId","value":"NC_002677.1"}]},{"database":"AlphaFoldDB","id":"Q49626","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"272631.gene:17575053","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mle:ML1222","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|272631.5.peg.2242","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"Leproma","id":"ML1222","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG50325BP","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_102917_0_0_11","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"4761780at2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000806","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"InterPro","id":"IPR021213","properties":[{"key":"EntryName","value":"DUF2567"}]},{"database":"Pfam","id":"PF10821","properties":[{"key":"EntryName","value":"DUF2567"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTEHCASDISDVSCPPRGRVIVGVVLGLAGTGALIGGLWAWIAPPIHAVVGLTRTGERGHDYLGNESEHFFVAPCLMLGLLTVLAVTASVLAWQLRQHRGPGMVIGLAIGLMICAATAAAVGALLVWMRYGALNFDAVPLSYDHKVAHVIQAPPVFFAHGLLQVAATVLWPAGIAALVYAVLAAANGRDDLGGRLCSR","length":198,"molWeight":20633,"crc64":"65B0422C4B584EBE","md5":"BA15B58C4541CD4D28AD75EB1CBCE31A"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Transmembrane":4},"uniParcId":"UPI000013ADA9"}}