{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3UST5","secondaryAccessions":["B7ZWC6"],"uniProtkbId":"CP089_MOUSE","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-06-16","entryVersion":106,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0764 protein C16orf89 homolog"}},"flag":"Precursor"},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Homodimer"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20578903"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20578903"}],"value":"Predominantly expressed in thyroid tissue"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20578903"}],"value":"From embryonic day (E) 17.5 onward in the developing mouse thyroid and lung"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"value":"Glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0764 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"UPF0764 protein C16orf89 homolog","featureId":"PRO_0000326203"},{"type":"Region","location":{"start":{"value":344,"modifier":"EXACT"},"end":{"value":385,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":356,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Sequence conflict","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"in Ref. 1; BAE24246","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Corpora quadrigemina","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-70VOHH7BF94TO","citationType":"submission","authors":["Mural R.J.","Adams M.D.","Myers E.W.","Smith H.O.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"20578903","citationType":"journal article","authors":["Afink G.B.","Veenboer G.","de Randamie J.","Keijser R.","Meischl C.","Niessen H.","Ris-Stalpers C."],"citationCrossReferences":[{"database":"PubMed","id":"20578903"},{"database":"DOI","id":"10.1089/thy.2009.0366"}],"title":"Initial characterization of C16orf89, a novel thyroid-specific gene.","publicationDate":"2010","journal":"Thyroid","firstPage":"811","lastPage":"821","volume":"20"},"referencePositions":["TISSUE SPECIFICITY","SUBCELLULAR LOCATION","DEVELOPMENTAL STAGE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK140126","properties":[{"key":"ProteinId","value":"BAE24246.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH466521","properties":[{"key":"ProteinId","value":"EDK97282.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC150828","properties":[{"key":"ProteinId","value":"AAI50829.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC171979","properties":[{"key":"ProteinId","value":"AAI71979.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS27934.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001028392.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001033220.4"}]},{"database":"AlphaFoldDB","id":"Q3UST5","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q3UST5","properties":[{"key":"Number of interactors","value":"139"}]},{"database":"STRING","id":"10090.ENSMUSP00000058860","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q3UST5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3UST5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000058860","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2199","properties":[{"key":"antibodies","value":"16 antibodies from 8 providers"}]},{"database":"Ensembl","id":"ENSMUST00000050160.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000058860.5"},{"key":"GeneId","value":"ENSMUSG00000051669.7"}]},{"database":"GeneID","id":"239691","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:239691","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc012aaz.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2146559","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2146559","properties":[{"key":"GeneName","value":"AU021092"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000051669","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RBYN","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000013433","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_051286_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3UST5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MTRPGCS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5949187at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q3UST5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"239691","properties":[{"key":"hits","value":"0 hits in 75 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3UST5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q3UST5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000051669","properties":[{"key":"ExpressionPatterns","value":"Expressed in olfactory epithelium and 81 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0042803","properties":[{"key":"GoTerm","value":"F:protein homodimerization activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR031751","properties":[{"key":"EntryName","value":"DUF4735"}]},{"database":"PANTHER","id":"PTHR33539","properties":[{"key":"EntryName","value":"UPF0764 PROTEIN C16ORF89"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR33539:SF1","properties":[{"key":"EntryName","value":"UPF0764 PROTEIN C16ORF89"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15882","properties":[{"key":"EntryName","value":"DUF4735"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARLGLLLLLLLALPPHFSSVSWPDTAQGTMANLILTALEKATLFLEDRLPTINLDGVVGFQVLEVQLRGVQEKWAHKPLLQPLSMRAGQMANTLSALLQKSIFYLKQSDPTYLREFQPSIQPGFWKLPNDWTRTNASLVYPWLEPLDSFSEESSDVCLVQLLGTGTDSSQPCRLSNFCRTLMTKAGCSGYSLSHQLLFFLWARMQGCTEGLFLQSQHYMDIFCANMMELNHRAEAVGYAYPTQDLFMENIMFCGMAGFSDFYKLRWLEAILSWQNPQVGCFGRPDTKGEPSEVPHQQGILRRVRRREKLFADGCSCHNTATAVAALGGFLYILAEYHPDNGDAHPEYYPNHGDPYSSSQSPASNYQDGAAGPDVQRTGRPLSVS","length":385,"molWeight":43079,"crc64":"735975B85A2BB72F","md5":"179D9C0E0798EA02F38FA194B0F63A73"},"extraAttributes":{"countByCommentType":{"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Region":1,"Compositional bias":1,"Sequence conflict":1},"uniParcId":"UPI0000511B89"}}