{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3U6Q4","secondaryAccessions":["Q3TBT5","Q3UAY4","Q8K323"],"uniProtkbId":"PI3R6_MOUSE","entryAudit":{"firstPublicDate":"2006-05-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-10-11","entryVersion":137,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Phosphoinositide 3-kinase regulatory subunit 6"}},"alternativeNames":[{"fullName":{"value":"Phosphoinositide 3-kinase gamma adapter protein of 87 kDa"}},{"fullName":{"value":"p84 PI3K adapter protein"},"shortNames":[{"value":"p84 PIKAP"}]},{"fullName":{"value":"p87 PI3K adapter protein"},"shortNames":[{"value":"p87PIKAP"}]}]},"genes":[{"geneName":{"value":"Pik3r6"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15797027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476736"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19906996"}],"value":"Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5UE93"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15797027"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476736"}],"value":"Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG (PubMed:15797027, PubMed:16476736). Interacts with beta-gamma G protein dimers (PubMed:16476736). Interacts with PDE3B and RAPGEF3; form a signaling complex that regulates phosphatidylinositol 3-kinase gamma in angiogenesis (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q3U6Q4","intActId":"EBI-4303950"},"interactantTwo":{"uniProtKBAccession":"Q9JHG7","geneName":"Pik3cg","intActId":"EBI-644372"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q3U6Q4","intActId":"EBI-4303950"},"interactantTwo":{"uniProtKBAccession":"P48736","geneName":"PIK3CG","intActId":"EBI-1030384"},"numberOfExperiments":6,"organismDiffer":true}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19906996"}],"value":"Translocated to the plasma membrane in a Ras-dependent manner (PubMed:19906996)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476736"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19906996"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19906996"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q3U6Q4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q3U6Q4-2"],"sequenceIds":["VSP_018257"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q3U6Q4-3"],"sequenceIds":["VSP_018255","VSP_018256"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476736"}],"value":"Highly expressed in heart. In a lower extent, also expressed in brain, spleen, lung, liver, kidney, prostate, thyroid, salivary gland, dendritic cells, macrophages and neutrophils"}],"commentType":"TISSUE SPECIFICITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"Phosphoinositide 3-kinase regulatory subunit 6","featureId":"PRO_0000234339"},{"type":"Region","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":589,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":738,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":717,"modifier":"EXACT"},"end":{"value":731,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":305,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_018255","alternativeSequence":{"originalSequence":"DLLQDRLPSIPLPSPYITFHLWTDQEQLWKELVLF","alternativeSequences":["KRGPAGDLPRETAIRRGGRQRARLDRMRFPEEPED"]}},{"type":"Alternative sequence","location":{"start":{"value":306,"modifier":"EXACT"},"end":{"value":756,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_018256","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":463,"modifier":"EXACT"},"end":{"value":466,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16476736"}],"featureId":"VSP_018257","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":710,"modifier":"EXACT"},"end":{"value":710,"modifier":"EXACT"}},"description":"in Ref. 2; BAE30180","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["G"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0037","category":"Biological process","name":"Angiogenesis"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16476736","citationType":"journal article","authors":["Voigt P.","Dorner M.B.","Schaefer M."],"citationCrossReferences":[{"database":"PubMed","id":"16476736"},{"database":"DOI","id":"10.1074/jbc.m512502200"}],"title":"Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.","publicationDate":"2006","journal":"J. Biol. Chem.","firstPage":"9977","lastPage":"9986","volume":"281"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","TISSUE SPECIFICITY","INTERACTION WITH PDE3B AND PIK3CG","SUBCELLULAR LOCATION","FUNCTION"]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary gland","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15797027","citationType":"journal article","authors":["Suire S.","Coadwell J.","Ferguson G.J.","Davidson K.","Hawkins P.","Stephens L."],"citationCrossReferences":[{"database":"PubMed","id":"15797027"},{"database":"DOI","id":"10.1016/j.cub.2005.02.020"}],"title":"p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.","publicationDate":"2005","journal":"Curr. Biol.","firstPage":"566","lastPage":"570","volume":"15"},"referencePositions":["INTERACTION WITH PIK3CG","FUNCTION"]},{"referenceNumber":6,"citation":{"id":"19906996","citationType":"journal article","authors":["Kurig B.","Shymanets A.","Bohnacker T.","Prajwal X.","Brock C.","Ahmadian M.R.","Schaefer M.","Gohla A.","Harteneck C.","Wymann M.P.","Jeanclos E.","Nurnberg B."],"citationCrossReferences":[{"database":"PubMed","id":"19906996"},{"database":"DOI","id":"10.1073/pnas.0905506106"}],"title":"Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"20312","lastPage":"20317","volume":"106"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY753194","properties":[{"key":"ProteinId","value":"AAV30089.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ295832","properties":[{"key":"ProteinId","value":"ABB97395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK151178","properties":[{"key":"ProteinId","value":"BAE30180.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK153039","properties":[{"key":"ProteinId","value":"BAE31670.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK171063","properties":[{"key":"ProteinId","value":"BAE42222.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC028998","properties":[{"key":"ProteinId","value":"AAH28998.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL606831","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS24866.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6Q4-2"},{"database":"CCDS","id":"CCDS36186.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6Q4-1"},{"database":"RefSeq","id":"NP_001004435.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001004435.3"}],"isoformId":"Q3U6Q4-2"},{"database":"RefSeq","id":"NP_001075035.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001081566.2"}],"isoformId":"Q3U6Q4-1"},{"database":"PDB","id":"8AJ8","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"8.50 A"},{"key":"Chains","value":"B/D/F/H=1-756"}]},{"database":"PDBsum","id":"8AJ8","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"CORUM","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-60179N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q3U6Q4","properties":[{"key":"Number of interactors","value":"718"}]},{"database":"IntAct","id":"Q3U6Q4","properties":[{"key":"Interactions","value":"4"}]},{"database":"STRING","id":"10090.ENSMUSP00000052522","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000052522","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"289560","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6Q4-1"},{"database":"ProteomicsDB","id":"289561","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6Q4-2"},{"database":"ProteomicsDB","id":"289562","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6Q4-3"},{"database":"Antibodypedia","id":"74162","properties":[{"key":"antibodies","value":"104 antibodies from 28 providers"}]},{"database":"DNASU","id":"104709","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000060441.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000052522.7"},{"key":"GeneId","value":"ENSMUSG00000046207.15"}],"isoformId":"Q3U6Q4-1"},{"database":"Ensembl","id":"ENSMUST00000102613.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000099673.2"},{"key":"GeneId","value":"ENSMUSG00000046207.15"}],"isoformId":"Q3U6Q4-2"},{"database":"GeneID","id":"104709","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:104709","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007jnq.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U6Q4-3"},{"database":"UCSC","id":"uc007jnr.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U6Q4-1"},{"database":"UCSC","id":"uc007jns.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U6Q4-2"},{"database":"AGR","id":"MGI:2144613","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"146850","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2144613","properties":[{"key":"GeneName","value":"Pik3r6"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000046207","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QSK4","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063753","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_023662_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"MPACWDG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"8781591at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.1.137","properties":[{"key":"OrganismId","value":"3474"}]},{"database":"Reactome","id":"R-MMU-114604","properties":[{"key":"PathwayName","value":"GPVI-mediated activation cascade"}]},{"database":"Reactome","id":"R-MMU-1257604","properties":[{"key":"PathwayName","value":"PIP3 activates AKT signaling"}]},{"database":"Reactome","id":"R-MMU-1660499","properties":[{"key":"PathwayName","value":"Synthesis of PIPs at the plasma membrane"}]},{"database":"Reactome","id":"R-MMU-389357","properties":[{"key":"PathwayName","value":"CD28 dependent PI3K/Akt signaling"}]},{"database":"Reactome","id":"R-MMU-392451","properties":[{"key":"PathwayName","value":"G beta:gamma signalling through PI3Kgamma"}]},{"database":"Reactome","id":"R-MMU-6811558","properties":[{"key":"PathwayName","value":"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"}]},{"database":"Reactome","id":"R-MMU-9927354","properties":[{"key":"PathwayName","value":"Co-stimulation by ICOS"}]},{"database":"BioGRID-ORCS","id":"104709","properties":[{"key":"hits","value":"4 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3U6Q4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q3U6Q4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000046207","properties":[{"key":"ExpressionPatterns","value":"Expressed in granulocyte and 120 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16476736"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19906996"}]},{"database":"GO","id":"GO:0005942","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005943","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex, class IA"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005944","properties":[{"key":"GoTerm","value":"C:phosphatidylinositol 3-kinase complex, class IB"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15797027"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19906996"}]},{"database":"GO","id":"GO:0046935","properties":[{"key":"GoTerm","value":"F:1-phosphatidylinositol-3-kinase regulator activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15797027"}]},{"database":"GO","id":"GO:0007186","properties":[{"key":"GoTerm","value":"P:G protein-coupled receptor signaling pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19906996"}]},{"database":"GO","id":"GO:0045766","properties":[{"key":"GoTerm","value":"P:positive regulation of angiogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043406","properties":[{"key":"GoTerm","value":"P:positive regulation of MAP kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19906996"}]},{"database":"GO","id":"GO:0045582","properties":[{"key":"GoTerm","value":"P:positive regulation of T cell differentiation"},{"key":"GoEvidenceType","value":"IMP:CACAO"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"12707323"}]},{"database":"GO","id":"GO:0042269","properties":[{"key":"GoTerm","value":"P:regulation of natural killer cell mediated cytotoxicity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR019522","properties":[{"key":"EntryName","value":"PIK3R5/6"}]},{"database":"PANTHER","id":"PTHR15593","properties":[{"key":"EntryName","value":"PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15593:SF1","properties":[{"key":"EntryName","value":"PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 6"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10486","properties":[{"key":"EntryName","value":"PI3K_1B_p101"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MESSDVELDFQRSVQAVLRELNTPNPALQSNQGMWRWSLHKKVERNPGKSSILVRILLRELEKAESEDGRRVIIPLLLTLMSVLTKATGIPEDLYHRAYTFCTRLLTLPAPYSTVALDCAIRLKTETAVPGTLYQRTVIAEQNLISELYPYQERVFLFVDPELVSASVCSALLLEIQAAQEQQTPEACMRHVVSHALQAALGEACHTGALNRKLQASSRRVLEYYFHAVVAAIEQVASEDSPSRLGHLEKMEEIYCSLLGPATTRRHCVGDLLQDRLPSIPLPSPYITFHLWTDQEQLWKELVLFLRPRSQLRLSADLDALDLQGFRLDRDLARVSTDSGIERDLPLGSDELPDPSSSEMERAALQRKGGIKKRVWPPDFFMPGSWDGPPGLHRRTGRPSGDGELLPGVSRVHTARVLVLGDDRMLGRLAQAYYRLRKRETKKFCLTPRLSLQLYYIPVLAPQVTGQDPEASRKPELGELASFLGRVDPWYESTVNTLCPAILKLAEMPPYLDTSRTVDPFILDVITYYVRMGTQPIYFQLYKVKIFTSLSHDPTEDIFLTELKVKIQDSKSPKEGSSPRRRGAAEGTGAELSMCYQKALLSHRPREVTVSLRATGLVLKAIPAGDTEVSGFFHCTSPNAASATDCSCLHVSVTEVVKSSNLAGRSFTTSTNTFRTSSIQVQSQDQRLLTLWLDKDGRRTFRDVVRFEVSPCPEPCSRTQKSKTSALNSHGQETEKNMAKPNSLLMPINTFSGIIQ","length":756,"molWeight":84663,"crc64":"5F3B56982C514876","md5":"57D66C9BFF31E3F42503516AD78EBBF8"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":1,"Alternative sequence":3,"Sequence conflict":1},"uniParcId":"UPI00001E5D49"}}