{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3U6N9","secondaryAccessions":["Q3URI5","Q9D0Z5"],"uniProtkbId":"CH033_MOUSE","entryAudit":{"firstPublicDate":"2007-10-02","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2005-10-11","entryVersion":117,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0488 protein C8orf33 homolog"}}},"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q3U6N9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q3U6N9-2"],"sequenceIds":["VSP_028170","VSP_028171"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q3U6N9-3"],"sequenceIds":["VSP_028170"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0488 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H7E9"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":222,"modifier":"EXACT"}},"description":"UPF0488 protein C8orf33 homolog","featureId":"PRO_0000304983"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":146,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":186,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":17,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":29,"modifier":"EXACT"},"end":{"value":39,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":93,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H7E9"}]},{"type":"Modified residue","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H7E9"}]},{"type":"Modified residue","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H7E9"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_028170","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":129,"modifier":"EXACT"},"end":{"value":129,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_028171","alternativeSequence":{}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"},{"value":"Embryo","type":"TISSUE"},{"value":"Head","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)"],"referenceComments":[{"value":"Czech II","type":"STRAIN"},{"value":"Mammary tumor","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK004154","properties":[{"key":"ProteinId","value":"BAB23195.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK141496","properties":[{"key":"ProteinId","value":"BAE24703.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK153059","properties":[{"key":"ProteinId","value":"BAE31685.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK160695","properties":[{"key":"ProteinId","value":"BAE35959.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC038324","properties":[{"key":"ProteinId","value":"AAH38324.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC091734","properties":[{"key":"ProteinId","value":"AAH91734.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS84175.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6N9-1"},{"database":"CCDS","id":"CCDS88794.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U6N9-3"},{"database":"RefSeq","id":"NP_001334469.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001347540.1"}],"isoformId":"Q3U6N9-1"},{"database":"RefSeq","id":"NP_473440.1","properties":[{"key":"NucleotideSequenceId","value":"NM_054099.3"}],"isoformId":"Q3U6N9-3"},{"database":"AlphaFoldDB","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q3U6N9","properties":[{"key":"Number of interactors","value":"70"}]},{"database":"STRING","id":"10090.ENSMUSP00000071698","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000071698","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28690","properties":[{"key":"antibodies","value":"80 antibodies from 12 providers"}]},{"database":"DNASU","id":"117171","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000071792.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000071698.6"},{"key":"GeneId","value":"ENSMUSG00000063236.7"}],"isoformId":"Q3U6N9-1"},{"database":"Ensembl","id":"ENSMUST00000229229.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000155387.2"},{"key":"GeneId","value":"ENSMUSG00000063236.7"}],"isoformId":"Q3U6N9-2"},{"database":"Ensembl","id":"ENSMUST00000230274.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000154907.2"},{"key":"GeneId","value":"ENSMUSG00000063236.7"}],"isoformId":"Q3U6N9-3"},{"database":"GeneID","id":"117171","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:117171","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007wmv.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U6N9-1"},{"database":"UCSC","id":"uc011zvd.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U6N9-2"},{"database":"AGR","id":"MGI:2152337","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2152337","properties":[{"key":"GeneName","value":"1110038F14Rik"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000063236","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S1RU","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000306","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_082144_1_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"PTCNDEG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"20277at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"117171","properties":[{"key":"hits","value":"3 hits in 70 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3U6N9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"Q3U6N9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000063236","properties":[{"key":"ExpressionPatterns","value":"Expressed in cleaving embryo and 265 other cell types or tissues"}]},{"database":"InterPro","id":"IPR029274","properties":[{"key":"EntryName","value":"DUF4615"}]},{"database":"PANTHER","id":"PTHR13602","properties":[{"key":"EntryName","value":"UPF0488 PROTEIN C8ORF33"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13602:SF2","properties":[{"key":"EntryName","value":"UPF0488 PROTEIN C8ORF33"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15393","properties":[{"key":"EntryName","value":"DUF4615"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAEPGRPAREAPAASSRKTHRAPRRPRPSRSASGASEPPLRSSVQPACDSAAGTHPVGNTVAMKQKKKKTPNRVSGTNGSEKPSEKPAPDEAPPSAEAQAEQLARELAWCVEQLELGLKTQRPTPKQKEQAVGAIRTLRSEKTPLPRKRQLMRSLFGDYRAQMDAEWREALRALKAATHSAQVQLVSEATRKKSGRVCRPRPAERAKTTPDLTSEEFRFNFF","length":222,"molWeight":24465,"crc64":"53D7B2DE0876A60C","md5":"5FE7FA66F844D38FE1D08C2E1982A157"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":3,"Compositional bias":4,"Modified residue":3,"Alternative sequence":2},"uniParcId":"UPI00005ACC6E"}}