{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3U595","uniProtkbId":"CV039_MOUSE","entryAudit":{"firstPublicDate":"2008-03-18","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2005-10-11","entryVersion":99,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Synaptic plasticity regulator PANTS"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"29571919"}],"value":"Plasticity-associated neural transcript short"}}]},"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Negatively regulates long-term potentiation and modulates adult synaptic plasticity (PubMed:35771867). Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites (PubMed:35771867). Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses (PubMed:35771867)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Interacts with RTN4 isoform A/Nogo-A; the interaction results in enhanced RTN4-mediated inhibition of AMPA receptor clustering (PubMed:35771867). Also interacts with NCAM1, RANBP2 and CCT8 (PubMed:35771867)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Detected in both the presynaptic and postsynaptic regions of the synapse and is secreted from neurons into the synaptic cleft (PubMed:35771867). May be released by neuronal dense core vesicles which mediate the release of cleaved neuropeptides (PubMed:35771867)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Synapse","id":"SL-0258"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Synaptic cleft","id":"SL-0517"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29571919"}],"value":"In the postnatal brain, expressed diffusely throughout the hippocampus at a low level at 8 weeks (at protein level) (PubMed:29571919). At 16 weeks, strongly expressed in the stratum lucidum of the hippocampus (at protein level) (PubMed:29571919). In developing and aging brain, expression is strongest in hippocampus, especially in areas CA3 and CA2, throughout the dorsoventral axis (PubMed:29571919)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29571919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Expression increases in the hippocampus between 8 and 16 weeks of age (at protein level) (PubMed:35771867). In brain, expression decreases steadily throughout embryonic development (PubMed:29571919). In liver, expression decreases between 11.5 dpc and 13.5 dpc and then remains relatively low (PubMed:29571919). Expression in the heart shows a 50% increase between 11.5 dpc and 13.5 dpc and then decreases (PubMed:29571919). In the postnatal brain, cerebellum levels decline (PubMed:29571919). In cortical tissue, expression significantly decreases by ~40% between P0 and 3 weeks and then returns to levels comparable to P0 in adult stages (PubMed:29571919). In the hippocampus, expression significantly drops by 40% between P0 and 3 weeks with a slight increase observed between 8 and 16 weeks of age (PubMed:29571919)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35771867"}],"value":"Rapidly degraded by proteolysis following neuronal stimulation, resulting in increased AMPA receptor clustering"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0545 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Synaptic plasticity regulator PANTS","featureId":"PRO_0000326131"}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"29571919","citationType":"journal article","authors":["Kragness S.","Harrison M.A.A.","Westmoreland J.J.","Burstain A.","Earls L.R."],"citationCrossReferences":[{"database":"PubMed","id":"29571919"},{"database":"DOI","id":"10.1016/j.gep.2018.03.004"}],"title":"Age-dependent expression pattern in the mammalian brain of a novel, small peptide encoded in the 22q11.2 deletion syndrome region.","publicationDate":"2018","journal":"Gene Expr. 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