{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q3U3D7","secondaryAccessions":["Q6P5E2","Q6PHM5","Q6ZQ24","Q8C2B9","Q8K2U7","Q8R3Y2","Q8R580"],"uniProtkbId":"T131L_MOUSE","entryAudit":{"firstPublicDate":"2008-04-08","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-10-11","entryVersion":116,"sequenceVersion":1},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Transmembrane protein 131-like"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"Tmem131l"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"Kiaa0922"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"In its membrane-associated form, antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"Endoplasmic reticulum","id":"SL-0095"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q3U3D7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q3U3D7-2"],"sequenceIds":["VSP_032833"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q3U3D7-3"],"sequenceIds":["VSP_032832","VSP_032833","VSP_032834"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TMEM131 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH29771.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH62940.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC40642.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":1597,"modifier":"EXACT"}},"description":"Transmembrane protein 131-like","featureId":"PRO_0000328866"},{"type":"Topological domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":870,"modifier":"EXACT"},"end":{"value":890,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":891,"modifier":"EXACT"},"end":{"value":1597,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":696,"modifier":"EXACT"},"end":{"value":916,"modifier":"EXACT"}},"description":"Required for Wnt-signaling inhibition and LRP6 degradation","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2VDJ0"}]},{"type":"Region","location":{"start":{"value":907,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1096,"modifier":"EXACT"},"end":{"value":1240,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1252,"modifier":"EXACT"},"end":{"value":1322,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":907,"modifier":"EXACT"},"end":{"value":917,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1213,"modifier":"EXACT"},"end":{"value":1222,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1223,"modifier":"EXACT"},"end":{"value":1239,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1269,"modifier":"EXACT"},"end":{"value":1290,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1291,"modifier":"EXACT"},"end":{"value":1319,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":343,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":593,"modifier":"EXACT"},"end":{"value":593,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":709,"modifier":"EXACT"},"end":{"value":709,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":846,"modifier":"EXACT"},"end":{"value":846,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":929,"modifier":"EXACT"},"end":{"value":930,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032832","alternativeSequence":{"originalSequence":"KS","alternativeSequences":["N"]}},{"type":"Alternative sequence","location":{"start":{"value":1275,"modifier":"EXACT"},"end":{"value":1335,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14621295"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032833","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1430,"modifier":"EXACT"},"end":{"value":1430,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_032834","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":357,"modifier":"EXACT"},"end":{"value":357,"modifier":"EXACT"}},"description":"in Ref. 3; BAC98050","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":368,"modifier":"EXACT"}},"description":"in Ref. 3; BAC98050","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":384,"modifier":"EXACT"},"end":{"value":384,"modifier":"EXACT"}},"description":"in Ref. 3; BAC98050","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["H"]}},{"type":"Sequence conflict","location":{"start":{"value":563,"modifier":"EXACT"},"end":{"value":563,"modifier":"EXACT"}},"description":"in Ref. 3; BAC98050","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":814,"modifier":"EXACT"},"end":{"value":814,"modifier":"EXACT"}},"description":"in Ref. 2; AAH62940","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":901,"modifier":"EXACT"},"end":{"value":901,"modifier":"EXACT"}},"description":"in Ref. 2; AAH23391","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"M","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":1014,"modifier":"EXACT"},"end":{"value":1014,"modifier":"EXACT"}},"description":"in Ref. 2; AAH23391","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":1081,"modifier":"EXACT"},"end":{"value":1081,"modifier":"EXACT"}},"description":"in Ref. 2; AAH23391","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Y","alternativeSequences":["C"]}},{"type":"Sequence conflict","location":{"start":{"value":1192,"modifier":"EXACT"},"end":{"value":1192,"modifier":"EXACT"}},"description":"in Ref. 1; BAC40642","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":1257,"modifier":"EXACT"},"end":{"value":1257,"modifier":"EXACT"}},"description":"in Ref. 2; AAH23391","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0879","category":"Biological process","name":"Wnt signaling pathway"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"NOD","type":"STRAIN"},{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 654-1597 (ISOFORM 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Czech II","type":"STRAIN"},{"value":"FVB/N","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14621295","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Koseki H.","Hiraoka S.","Saga Y.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"14621295"},{"database":"DOI","id":"10.1093/dnares/10.4.167"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"167","lastPage":"180","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-1597 (ISOFORM 2)"],"referenceComments":[{"value":"Embryonic tail","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK088900","properties":[{"key":"ProteinId","value":"BAC40642.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK154818","properties":[{"key":"ProteinId","value":"BAE32851.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC023166","properties":[{"key":"ProteinId","value":"AAH23166.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC023391","properties":[{"key":"ProteinId","value":"AAH23391.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC029771","properties":[{"key":"ProteinId","value":"AAH29771.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC056491","properties":[{"key":"ProteinId","value":"AAH56491.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC062940","properties":[{"key":"ProteinId","value":"AAH62940.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK129240","properties":[{"key":"ProteinId","value":"BAC98050.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS38463.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U3D7-1"},{"database":"RefSeq","id":"NP_766269.3","properties":[{"key":"NucleotideSequenceId","value":"NM_172681.5"}],"isoformId":"Q3U3D7-1"},{"database":"RefSeq","id":"XP_006501388.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006501325.2"}],"isoformId":"Q3U3D7-2"},{"database":"AlphaFoldDB","id":"Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"230845","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q3U3D7","properties":[{"key":"Number of interactors","value":"855"}]},{"database":"STRING","id":"10090.ENSMUSP00000141438","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q3U3D7","properties":[{"key":"glycosylation","value":"4 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q3U3D7","properties":[{"key":"glycosylation","value":"5 sites, 2 N-linked glycans (2 sites)"}]},{"database":"iPTMnet","id":"Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000141438","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"254517","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U3D7-1"},{"database":"ProteomicsDB","id":"254518","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U3D7-2"},{"database":"ProteomicsDB","id":"254519","properties":[{"key":"Description","value":"-"}],"isoformId":"Q3U3D7-3"},{"database":"Antibodypedia","id":"57011","properties":[{"key":"antibodies","value":"64 antibodies from 13 providers"}]},{"database":"DNASU","id":"229473","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000191758.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000141438.2"},{"key":"GeneId","value":"ENSMUSG00000033767.15"}],"isoformId":"Q3U3D7-1"},{"database":"Ensembl","id":"ENSMUST00000192095.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000141607.2"},{"key":"GeneId","value":"ENSMUSG00000033767.15"}],"isoformId":"Q3U3D7-3"},{"database":"GeneID","id":"229473","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:229473","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008ppo.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U3D7-2"},{"database":"UCSC","id":"uc008ppp.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U3D7-1"},{"database":"UCSC","id":"uc008ppq.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q3U3D7-3"},{"database":"AGR","id":"MGI:2443399","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23240","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2443399","properties":[{"key":"GeneName","value":"Tmem131l"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000033767","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3620","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063614","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_004094_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FINSPPY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"168404at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"229473","properties":[{"key":"hits","value":"4 hits in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q3U3D7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q3U3D7","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000033767","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular zone and 250 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q3U3D7","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0090090","properties":[{"key":"GoTerm","value":"P:negative regulation of canonical Wnt signaling pathway"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033088","properties":[{"key":"GoTerm","value":"P:negative regulation of immature T cell proliferation in thymus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"FunFam","id":"2.60.40.10:FF:000687","properties":[{"key":"EntryName","value":"transmembrane protein 131-like isoform X3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR055435","properties":[{"key":"EntryName","value":"Ig_TMEM131L_3"}]},{"database":"InterPro","id":"IPR055436","properties":[{"key":"EntryName","value":"Ig_TMEM131L_4"}]},{"database":"InterPro","id":"IPR039877","properties":[{"key":"EntryName","value":"TMEM131-like"}]},{"database":"InterPro","id":"IPR045695","properties":[{"key":"EntryName","value":"TMEM131-like_Ig_dom2"}]},{"database":"InterPro","id":"IPR055437","properties":[{"key":"EntryName","value":"TMEM131L_Ig_5"}]},{"database":"InterPro","id":"IPR022113","properties":[{"key":"EntryName","value":"TMEM131L_N"}]},{"database":"PANTHER","id":"PTHR22050","properties":[{"key":"EntryName","value":"RW1 PROTEIN HOMOLOG"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR22050:SF2","properties":[{"key":"EntryName","value":"TRANSMEMBRANE PROTEIN 131-LIKE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19532","properties":[{"key":"EntryName","value":"Ig_TMEM131L_2nd"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24498","properties":[{"key":"EntryName","value":"Ig_TMEM131L_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24499","properties":[{"key":"EntryName","value":"Ig_TMEM131L_4"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24501","properties":[{"key":"EntryName","value":"Ig_TMEM131L_5"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12371","properties":[{"key":"EntryName","value":"TMEM131_like_N"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAGLRRPQSGAYRRTAAAVNLLLGVFQVLLSCCRPGGAQGQAFEPLPNVVELWQAEEGELLLPTQGDSEEDMEEPSQEQSFSDKLFIGKGLHFQPSVLDFGIQFLGHPAAKLLYAYNPSRESEVVVNSVFTAARHFHVPPVHCRVIPAMGKASFRVIFLPTEEGSIESSLFINTSSHGVFSYHVSGVGTRRVSTEGSAEQLPNAYFLLPQVQSIQLSQTQAETTNTSLLRVQLECSLHNKVCQQLKSCSLGSDDALHLEMNIIVAVENSSKQPEENTQALLDHLSIVYVATDESDTSDESAVNMYVLHSGNSLIWIQDIHHFSQKNVLSLQFEPVLLSTSTTNFTKIASFTCKAGTSCDSGIMGLRKKKASPAMQACLSSPVVQGYFRTDASTAQFHIESHETATGVWSIWYRSHFDQSIVLKDVFVSKETKHILKVLSFRGPLFLPPGCWNIFSLKLAVKGIVLNLFTNVFLTTNTGAIFAIPLQIFSAPTKEGSLGFEVLAHCGMHYFMGKSKTENPNWERSLSLDRSTWDMDSELANKLYERWKKYKSGDACRRNVLGMSQFAFTKKSKETEPFVSFLPRVVPEPNLVLNFSATALRNSAVKYFVVRNPTPQPVSLQLLPLSLYPRPEAAVRLLHKWFGTDMQMVNLSTGEFQLTQACPYQGEPSEESSLGALHVHLQALETRRVGVVFTPADYGKVTSLILIRNNLTVVDMVGVEGFGAQELLKVGGRLPGAGGSLRFKVPESTLMDCHRQLKDSKQILSITKNFKVENIGPLPITVTSLKINGYNCQGYGFEVLDCHPFSLSPNTSRDISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHMLPLCAEVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNGSSSSQQNGDPVAMISSHPHKSTCKNFLDTYSPSDKGRGKSCLPVGPSLSRLQNAAKRSPATYGHSQKKHKCSFYYSKQKPSASAASSANVTTEEKQTVTLASSLSVAKEDICTNVLSENWVSLRYASGINGSLQKNLTLPKNVLHKEESSLKNTVVTNTPSECSMKEGVHTYMFPKETDSKISENVAELKEQEPCPQKTSKKPPESTLPKTPPQYLQSDLPEVSRKHGNKQQAPVRSEVDSFEPVRAADAEPSSVRKTQGASPEDTCSEKQDTPSAEQEDPSRKRKLQERREGSTQALNWNKTRPCRRNKKRASAQASSSPRPSEQSEQRLVCSDVRSWCAQDGAGEKCKAGTEVSGSSPERREEDSYYQKSEKKCADKFCSDSSSDCGSSSGSVRASRGSWGSWSSSSSDCDRRPVVDIQHFLPPGDGVSPQNFPSEASVPLSLPQHVCSSTDVSVLPEFTESPCPGLPATPAGAGEEKGLYPPGGLWPSQPVCLTSSFNCPVENGAPGVSQEPTSIPDSSFIDWSASCEGQFPSVYCPLELNDYNAFPEENMNYTNGFPCSSKVQTDFIGHSTPSTWNTPASMPAAWGHASLVNSPSYLTSTRSLSPMSGLFGSIWAPQSEVYETCCPISPATEHATHMENQVMCKEYYLGFNPFRAYMNLDIWTSTANRNANFPLSRDSSYCGNM","length":1597,"molWeight":175772,"crc64":"A1EEEAA94AD2FA20","md5":"2C066479F1AFCFD8F41842ACF4024E97"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Region":4,"Compositional bias":5,"Glycosylation":4,"Alternative sequence":3,"Sequence conflict":10},"uniParcId":"UPI00001C2C03"}}