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Osmosensitive cation channel preferentially activated by hypotonic stress (PubMed:27045885). Also acts as a phospholipid scramblase in response to changes in membrane structure: upon changes in membrane curvature and thickness, alters its conformation and translocates phospholipids, such as phosphatidylcholine and sphingomyelin, thereby controlling plasma membrane lipid distribution (PubMed:39217145, PubMed:39424995). Forms a heterodimer with SLC19A2, which mediates phospholipid scramblase activity following Ca(2+) stimulation (PubMed:39217145). Expressed in excitatory neurons of the subfornical organ and functions as a thirst receptor that mediates neuronal response to hyperosmolality to drive thirst and drinking behavior (PubMed:38172113, PubMed:40107268). Facilitates intestinal motility by promoting proliferation of intestinal stem cells (PubMed:39513891). Essential for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Acts as an osmosensor in cochlear outer hair cells (OHCs) where it mediates calcium influx and regulatory volume decrease response (PubMed:32375046). Required for the maintenance of OHC morphology, OHC survival and normal hearing (PubMed:32375046)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33100268"}],"value":"Brain-specific osmosensitive calcium channel isoform"}],"commentType":"FUNCTION","molecule":"Isoform 2"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31243992"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32375046"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37945568"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Mg(2+)(in) = Mg(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29827"},{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32375046"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"K(+)(in) = K(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29463"},{"database":"ChEBI","id":"CHEBI:29103"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32375046"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Na(+)(in) = Na(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:34963"},{"database":"ChEBI","id":"CHEBI:29101"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32375046"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Cs(+)(in) = Cs(+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:78555"},{"database":"ChEBI","id":"CHEBI:49547"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32375046"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:38571"},{"database":"ChEBI","id":"CHEBI:57643"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39424995"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a sphingomyelin(in) = a sphingomyelin(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:39727"},{"database":"ChEBI","id":"CHEBI:17636"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39424995"}]}},{"commentType":"CATALYTIC ACTIVITY","molecule":"Isoform 2","reaction":{"name":"Ca(2+)(in) = Ca(2+)(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29671"},{"database":"ChEBI","id":"CHEBI:29108"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33100268"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37402734"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37543036"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39217145"}],"value":"Monomer (PubMed:37402734, PubMed:37543036). 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Conditional deletion in excitatory neurons of the subfornical organ leads to impaired hyperosmolarity-induced drinking behavior (PubMed:38172113, PubMed:40107268). 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